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On January 8th, Aouita 11 HarmonyOS version of Zhixiang upgrade was officially launched. The car has mainly undergone four upgrades: intelligent driving upgrade, equipped with map-free NCA function that does not rely on high-precision maps; Comfort upgrade, four somatosensory optimizations; Chassis upgrade, adding Huawei iTRACK function; The rights and interests are upgraded, and the "intelligent" highest rights and interests can be enjoyed for life. Moreover, there is no price increase in the whole department, and the prices of 90-degree rear-drive version 300,000 yuan, 116-degree rear-drive version 335,000 yuan, 90-degree luxury version 350,000 yuan and 116-degree luxury version 390,000 yuan remain unchanged.

With the launch of this car, Aouita has entered the era of intelligent driving with "de-high-precision mapping", which effectively makes up for the shortcomings of the intelligent driving scheme with high-precision maps, not only solves the pain point of "following the map", but also unlocks more high-frequency intelligent driving scenes. It is reported that its urban NCA intelligent driving function will unlock more than 300 cities at one time, bringing users a travel experience of "all the country can open and all the country can open".

Thanks to the industry’s top-stream vehicle-side perception and calculation ability brought by three laser radars that are fully equipped at the beginning, Aouita 11 can land quickly without relying on the intelligent driving NCA function of high-precision maps. Aouita 11′ s intelligent driving system integrates the Road Topology Reasoning Network (RCR) and the industry’s first GOD network to build real-time road information, identify all kinds of obstacles sensitively, and improve the safety of human driving and intelligent driving.

Aouita 11′ s intelligent driving system can make rapid and reasonable vehicle movement planning and path planning, and its driving style is more "human-like". In case of repairing subway, tidal lane, temporary road changes caused by traffic control and other scenes, the intelligent driving system can make up for the difference of iteration period of high-precision maps, and truly drive with or without maps, and the complex road conditions will not be degraded. In response to daily commuting and self-driving cross-provincial travel scenarios, the intelligent driving system can independently choose roads with higher traffic efficiency.

Combined with user feedback, the car has also been optimized for the leg, waist, back and sitting posture of the seat, so that users can have a comfortable experience no matter which seat they are in or which sitting posture they take. At the same time, the chassis of the car is upgraded with Huawei iTRACK architecture, which can realize ultra-fine road condition perception of 10,000 times per second and real-time adjustment of torque of 1,000 times per second, so as to realize the best power output mode under different road conditions and create the best driving experience.

Huawei’s iTRACK function "makes the road smooth". Aiming at the most common speed bump scene in daily life, Huawei iTRACK accurately identifies the wheel speed fluctuation, and adjusts and controls the torque within milliseconds to achieve rapid convergence. Through the actual measurement, the wheel speed fluctuation can be reduced by 50% and the aftershock time can be shortened by 40%, thus effectively improving the comfort and safety of the whole vehicle and bringing better driving experience to users.　

The rights and interests are easy to upgrade. From now until February 29, 2024, car buyers can choose one of the following rights and interests: rights and interests 1. Users who buy cars after January 8 will be given a high-end smart driving bag worth 26,000 yuan; Second, during the activity, car buyers can enjoy the discount of paying a deposit of 5,000 yuan to offset the car payment of 25,000 yuan. In addition, Aouita also introduced more car benefits in a limited time, including: the first car owner’s lifetime three-electricity warranty; 6000 yuan replacement subsidy; Give away the intelligent fragrance system; The down payment starts from 42,000 yuan, and the full-term ultra-low interest financial concessions.

Upstream news Wu Jian

Editor: Wang Xinyu Editor: Kevin·Z Audit: Lei Zhao

　　Recently, the domestic automobile market has ushered in a wave of price reduction. Both fuel vehicles and new energy vehicles have begun to lay down their bodies to earn money, which has also intensified the fierce competition in the market. Therefore, many models have taken the opportunity to usher in updates and upgrades, such as the following three new energy vehicles, which are worthy of attention.

　　Bound M5

　　Manufacturer’s guide price: 259,800-331,800 yuan.

　

　　Although HUAWEI has repeatedly said that it will not build cars, the well-known "AITO Jiejie" has recently become "HUAWEI Jiejie". It can be seen that Huawei has more and more control over the brand of Jiejie. Just recently, the Ministry of Industry and Information Technology has exposed the declaration information of the new model of Jiejie M5, and the new car is expected to add the "Huawei" logo at the tail, so owners don’t have to pick the label!

　
　

　　The main upgrade of the new cross-section M5 is assisted driving. It can be seen from the figure that a laser radar and a full-angle ADAS camera are added above the front of the car, and its computing unit will also be replaced by Huawei’s self-developed MDC, which is not just as simple as changing the standard. In fact, the current cross-section M5 has already achieved L2+ level assisted driving, and the appearance of laser radar will further strengthen its hard power. In the power part, the new car will continue to be equipped with an extended-range hybrid system. Although only two models have been released by the car industry, I have seen many real cars on the road, most of which are the M5, and in January, the M5 ushered in the official price reduction. With the arrival of new models and the increase of configuration, are you optimistic about the performance of the M5 in the next car market scuffle?

　　Tucki P7

　　Manufacturer’s guide price: 209,900-339,900 yuan.

　

　　It’s been three years since Tucki P7 was listed. In the previous era of fuel vehicles, it wouldn’t hurt if it didn’t change the model for three years. However, in the rapidly developing new energy automobile market, various technologies are rapidly iterating, and the competitiveness of P7 is also declining. Therefore, this month, we ushered in an upgraded new Tucki P7i, which will help Tucki to return to the front ranks.

　
　

　　P7i is not just a simple change. It has been upgraded in many aspects, such as vehicle function, comfort configuration, three-electric system, handling performance, intelligent platform, etc. For example, it is equipped with the second-generation intelligent assisted driving system XNGP, and two laser radars are added to the sensor. The intelligent assisted driving chip is equipped with dual Orion-X chips (Xavier in cash), providing high computing power of 508TOPS (30TOPS in cash), which is ultra-high-standard. Secondly, the cockpit hardware was upgraded from 820A to Snapdragon SA8155P, and the interior style was in line with G9. The whole system was equipped with electric suction door, electric tailgate, privacy glass and so on as standard. In addition, in terms of power, the new two-wheel drive version was equipped with a motor of 203 kW/440 N m, and the parameters of the four-wheel drive version were 348 kW/757 N m, which improved obviously in all aspects. However, I think it is more important to launch an entry-level version equipped with a 60-degree battery to lower the price. What do you think?

　　On April 18th, according to the latest data of RUNTO, in the first quarter of 2024, the omni-channel sales volume of China smart door lock market was 3.86 million sets, down 1.4% year-on-year.

　　Among them, online omni-channel data shows that Xiaomi, Deshman and Kaidishi are in the top three in terms of sales volume and sales volume.

　　Xiaomi’s sales share reached 14.7%, ranking first in online omni-channel sales, and it is a fault-leading.

　　Xiaomi smart door lock has advantages in product cost performance, brand awareness and scene ecology, especially in many price segments below 2500 yuan.

　　In Q1, 2024, China smart door lock online omni-channel brand sales share.

　　Deschman’s sales share is close to 20%, ranking first in online omni-channel sales, followed by Xiaomi.

　　Huawei’s smart door lock performance is also very outstanding, mainly promoting high-end products, ranking fourth in the sales volume dimension by virtue of its brand influence and channel advantages.

　　According to the analysis, in the second quarter, the online market of smart door locks will continue to be hot under the stimulation of promotional activities such as Jiazhuang Festival and 618.

　　RUNTO judges that in the first half of 2024, the omni-channel sales of smart door locks in China will reach 8.8 million sets, with the year-on-year decline narrowed to 1%.

　　On April 16th, Xiaomi Mijia Intelligent Invisible Clothes Dryer has been officially put on the shelves and started crowdfunding activities. The crowdfunding price of single product is only 999 yuan, and the crowdfunding price of set is even more favorable to 1898 yuan.

　　In terms of design, this clothes dryer adopts an innovative 8cm ultra-narrow machine design, which is perfectly embedded in the ceiling, which is not only beautiful and generous, but also saves space. At the same time, the design of the reserved manhole makes it unnecessary to disassemble the ceiling for after-sales maintenance, which greatly facilitates the daily use and maintenance of users.

　　Mijia Intelligent Invisible Clothes Dryer has built-in 36W gradual lighting, which not only provides sufficient lighting, but also has night light mode. Users can easily adjust brightness and color temperature through Mijia App to create a comfortable clothes drying environment.

　　The clothes drying machine adopts the design of wave-shaped drying rod and open windproof drying hole, which is not only beautiful and practical, but also makes it more convenient to hang clothes without aiming at the drying hole.

　　In addition, this clothes dryer also supports Xiaomi 澎湃 Zhilian technology, which can realize intelligent linkage with other Xiaomi smart home devices. Through the scene setting of Mijia APP, users can easily realize the intelligent control of clothes dryers, washing machines, intelligent curtain and other equipment, and create a more intelligent life experience.

　　In the aspect of intelligent drying system, Mijia intelligent invisible clothes drying machine provides rich functions. It has five intelligent functions, such as two-stage ascending protection, self-defined ascending and descending height, rebounding when ascending meets resistance, stopping when descending meets resistance and gently lifting and ascending, to provide users with a safer and more convenient clothes drying experience.

　　In terms of quality, Xiaomi Mijia intelligent invisible clothes dryer also performed well. It adopts six-series aluminum alloy and national standard 304 steel wire rope. After 6000 times of rigorous lifting durability tests, the bearing capacity reaches 30kg. At the same time, its DC motor adopts new noise sealing control technology, and the maximum noise is as low as 55dBA, which brings users a quiet experience.

　　My mother, my grandmother, and their two generations of married women, all together, are those things of mother-in-law and sister-in-law, all kinds of spit, dissatisfaction and gossip. In our generation, middle-aged girls got together, and all the objects of spitting became their own babies. The middle age here has nothing to do with age, especially the mothers whose children go to middle school.
　　It’s okay for children to go to elementary school, it’s not too expensive for mom, and friends circle can occasionally see sunbathing babies. Even if there is some disharmony, mothers can laugh it off in a teasing tone. Since Eva entered junior high school, her painting style has reversed. Parent-child relationship has encountered unprecedented tension in the cold winter.
　　The sunshine is just right, and the breeze is not dry. on the boulevard, a park near a middle school, is crowded with middle-aged women. Waiting for the children’s gap, they came to a "complaining conference." A crackling, crazy output, comparable to the live broadcast of the dissatisfied wife.
　　"My boy, now in high school, is a bully! Why don’t you fight? I still can’t beat him! " Mother Li patted her knees with indignation, as if to take a picture of her disappointing son and hang it up for public display. Next to Zhang’s mother, she nodded: "It’s true that it’s early to hit the child. I can’t beat my son now."
　　"Ah, you this calculate what, my princess is a difficult to serve! As soon as I got home, I knew it was hard to talk to her with my mobile phone. We are both disgusted now. " Mother Wang shook her head and sighed. Where is the little princess who used to be good at singing and dancing and often danced in her circle of friends? "You this is nothing, my family that is really a little ancestor, don’t do homework, don’t tidy up the room, play games, and talk back! Threatening me at every turn. " Cao’ s mother looked helpless and had a full face of "life without love".
　　The sense of the picture is coming. A group of middle-aged women are sitting together. At this moment, they are comrades-in-arms in the same trench and partners who talk to each other-complaining partners. Everyone’s face says, "I’m too difficult." Their expressions are colorful, from anger to helplessness, from sighing to wry smile, just like a living picture of parents.
　　"Now the child zha? Eat, drink, serve, and always give us a slap in the face. When we were young, how could we be so worried? " Mother Liu suddenly launched a philosophical thinking, and her eyes flashed with beautiful memories of the past. Mother Chen took over the conversation, as if she had returned to that obedient era: "Yes, at that time, our parents were uncompromising, so how dare they not listen."
　　A wave of memory killings, a bitter memory, and a gnashing accusation …
　　The school bell rang at the right time, ending this "complaining conference". Mothers got up one after another, quickly switched to another mode, put on a smile and walked over to the children. With the output just now, some of the emotional garbage has been dumped, and mothers can fight against the sky and face the pieces of life with great energy.

□ Zhang Chunmiao

　

Text: the sound of trees and grass in the forest

　

Proofreading: Chao Gan/Editor: Guo Licheng

　

Houston, an American city no stranger to China, is well-known for its rocket team and space city. People are deeply impressed by its developed petrochemical industry, staggered pipelines and busy factory ports.

　

There are more than rockets and oil behind Houston’s prosperity.

　

(Photo: shutterstock)▼

　

　

But to say that Houston’s most prosperous industry, it has to be the following:

　

The annual output value is as high as $14 billion, more than 90,000 people go to work, and many top medical institutions and researchers gather. By the way, one of the largest medical complexes in the world supports a quarter of Houston’s hotel business.Dezhou medical center.

　

Texas Medical Center "supported" a city on its own.

　

(Photo: Yitu. com) ▼

　

　

This achievement of Texas Medical Center was not achieved overnight, but was a leader in the industrial transformation of the United States for decades. Due to the large number of well-known hospitals gathered here, the supporting medical equipment, industry exhibitions, health consultation and other industries have also developed.

　

Compared with today’s depressed Great Lakes rust belt, Houston is still full of vitality.

　

Industrial explosion in the aging era

　

Houston’s success in the pharmaceutical industry, on the one hand, benefits from the strong strength of universities, scientific research and talents, but as an industry, the most fundamental reason for its rise is stillFundamental transformation of social population structure.

　

76 million people were born in the "baby boom" in the United States from 1945 to 1964, and the average age of the American population has been rising since then. Despite the continuous immigration supplement, compared with the obviously increased elderly population, the incidence of a series of diseases such as diabetes, cancer and Alzheimer’s disease is bound to increase, and the pharmaceutical market is bound to expand.

　

The baby boomers are getting old.

　

Directly raised the average age of the American population ▼

　

　

Aging is not exclusive to Europe and America.With the inevitable trend of economic development and fertility decline, China is no exception.. Moreover, China people’s awareness and demand for health are also obviously improving, which can be seen from the financial market: in the past 20 years, the pharmaceutical and biological industries have increased sevenfold, ranking among the top five in all industries; The scale of biomedical ETF(512290) is also rising step by step.

　

The pharmaceutical and biological industries are growing rapidly ▼

　

　

Biomedical ETF▼

　

　

In the age of aging, diabetes and obesity have become a problem that almost everyone has to face. At present, there are about 537 million people with diabetes in the world aged 20-79. Nowadays, the sale of all kinds of sugar-free drinks and foods on the market is a manifestation of people’s worries.

　

The treatment of diabetes, a chronic disease, is a worldwide problem. Otherwise, there will be no so-called "ancestral secret recipes" flying all over the sky. However,The emergence of GLP-1 drugs will be a blessing for patients..

　

GLP-1 (human glucagon-like peptide -1) is a protein secreted by human intestinal cells, which can promote human insulin secretion. However, GLP-1 secreted by human body is easy to be decomposed by other enzymes, and will not act for a long time. Then, if we improve the structure of GLP-1 so that it is not easy to be decomposed, won’t it promote insulin secretion for a long time and treat diabetes?

　

▼

　

　

Science magazine listed the related research of GLP-1 as the top ten scientific breakthroughs in 2023.Among them, the most famous drug is undoubtedly Smegliptide, which has occupied half of the field of diabetes..

　

(Note: At present, this drug is only approved for the treatment of diabetes in China, but it has not been approved for weight loss! )

　

Smegliptide also shows great potential in the prevention and treatment of Alzheimer’s disease, nonalcoholic hepatitis, cancer and kidney disease, and it is quite aspirin-like "cure all diseases". In October last year, after Novo Nordisk announced the "positive experimental results" of smegliptide in the treatment of diabetic nephropathy, the share prices of many dialysis manufacturers fell. And this story has happened many times in the medical field.

　

The announcement shows that the efficacy of smegliptide has reached the expectation.

　

Therefore, the experiment was terminated early ▼

　

　

Lilly, a pharmaceutical giant, was originally a small company, but relied on its keen sense of smell to take the lead in obtaining insulin patents and monopolize the global market. However, in the 1980s, Novo Nordisk insulin injection pen went on the market, and this convenient and easy-to-use product sold well when it went on the market, which opened the era of hegemony in the diabetes drug market.

　

All these remind people that technology is constantly reshaping this market.An innovative achievement may create a new giant.; Another case is the wave caused by the listing of oral version of smegliptide in China in early 2024.

　

The oral version is also only approved for diabetes treatment.

　

Not approved for general weight loss!

　

(Photo: National Medical Products Administration) ▼

　

　

Massive capital investment and endless new achievements have created a vibrant biomedical industry today. In the past few decades, China, the fastest growing economy in the world, actually has a long-term shortcoming in the biomedical industry.Can you make up this short board?

　

China medicine, difficult to move forward.

　

Taking medicine when you are sick is something that everyone has to experience. However, the expensive drug price has become a pain in patients’ hearts. The dilemma in Dying to Survive may happen to each of us.

　

The reason why the drug price is so high is related to the current high cost of drug research and development:10 years, 1 billion dollars. For a long time, the pharmaceutical industry has been dominated by a group of large multinational pharmaceutical companies. On the one hand, it has high research and development costs and technical barriers. On the other hand, monopoly status means strong pricing power. Such a market situation has created amazing profit margins for large pharmaceutical companies: in 2023, the annual sales of smeagoutide reached $21.142 billion.

　

Novo Nordisk Meglumine Peptide Related Products Financial Report ▼

　

　

The pharmaceutical industry in New China originated from the eldest son of the Republic medicine-Shijiazhuang Huabei Pharmaceutical FactoryThe first batch of domestic penicillin in China was born here. However, due to our late start and weak foundation, we have never had any industrial advantages except for traditional Chinese medicine products with local characteristics for a long time. When foreign pharmaceutical companies with strong R&D strength and mature business model enter China, they are like wolves in the flock. If they don’t catch up, the pharmaceutical market of more than one billion people will be completely lost.

　

Chinese medicine is a symbol of moderns in Shijiazhuang ▼

　

　

At that time, China’s R&D ability was very weak, so we could only start with the production of basic raw materials for drugs. The ingredients of the raw materials are fixed, and the production process is relatively mature. As long as you are willing to do it, you can produce products. But the middle and lower reaches of this international industrial chain can receive a large number of orders only because of low labor costs. Moreover, the technological level was limited at that time, and the pollution in the production process was very serious.

　

This is obviously not a long-term solution. The vast market of all kinds of new drugs attracts China enterprises. Since they can’t make high profits in developing new drugs, let’s start with generic drugs and get a slice of the huge market first. Nowadays, many backbone enterprises in the pharmaceutical industry in China (such asHengrui Pharma, the heavyweight stock of biomedical ETF), it is in these two waves that the initial accumulation has been completed and it has moved to the upper reaches of the industrial chain.

　

From generic drugs to self-developed drugs

　

Enterprises need a certain amount of time to accumulate and precipitate.

　

(Photo: Picture Worm Creativity) ▼

　

　

At this time, the pharmaceutical industry in China has made great progress. But after all, I still follow in the footsteps of others, and I only earn a fraction of the big international pharmaceutical companies. If you really want to gain a foothold in the biomedical industry, you need to come up with your own things and change the old thinking and industrial model as a whole.Only by thoroughly remoulding oneself can we really grow up.

　

It is not only an economic and commercial issue to enlarge the local pharmaceutical industry. Even in the era of high globalization, the regional differences of health problems in different countries need the developed biomedical industry in their own countries.

　

For example, the Texas Medical Center mentioned at the beginning

　

Has the largest cancer center in the United States

　

(Photo: MD Anderson)▼

　

　

For example, due to the differences of environment and living habits in different countries, the incidence of cancer, the big health killer in the aging era, is different in different countries. The incidence of lung cancer and nasopharyngeal carcinoma in China is obviously higher than that in Europe and America, and esophageal cancer patients account for half of the world. Only by establishing an independent biomedical industry system can we better provide targeted treatment for patients.

　

Make your own medicine

　

Cancer, in most people’s minds, is equated with terminal illness. But the progress of modern medicine is enough to make this an old yellow calendar.

　

One of the major difficulties in cancer treatment is that cancer tissue has a strong ability to deceive, and it will "hide" itself under the guise of the identification mechanism in the human immune system to prevent cannibalism. In other words, if drugs can be used to "remind" the immune system and "catch the mole", it can play a role in preventing and treating cancer.

　

"There is a mole, terminate the transaction."

　

(T cells surround identified cancer cells)

　

(Photo: NICHD/J. Lippincott-Schwartz)▼

　

　

Research in this field has been carried out for decades, among whichPD-1/PD-L1 has attracted much attention from scientists.. Cancer cells will suppress T cells through this in vivo inhibitor, making it think it is a "friendly army". Scientists have developed drugs to block the inhibitory signal pathway between T cells and tumor cells, so as to "restart" the human anti-cancer mechanism.

　

Microscopically, PD-L1 positive lung adenocarcinoma cells

　

(Photo: wiki)▼

　

　

Such drug development requires high technology and in-depth study of human immune system. In the past, it was estimated that multinational pharmaceutical companies developed and sold high prices, and then domestic pharmaceutical companies waited for the patent period to pass a wave of imitation. However, times have changed.

　

By the end of 2023, 17 PD-(L)1 products have been approved for listing in China market, of which more than half are domestic products. In addition to PD-1 target, drugs such as PARP and CDK4/6 have also been successfully developed. Hengrui Pharma is one of the most important manufacturers in this field in China. Its biopharmaceutical products cover lung cancer, nasopharyngeal carcinoma and other high-risk cancer categories in China, and a large number of drugs are in the clinical research stage.

　

Some cancer-related drugs in Hengrui Pharma.

　

(Photo: Hengrui Pharma) ▼

　

　

But at present, the human response rate of PD-(L)1 drug is not high enough, and scientists are still improving it.

　

Since antibodies can recognize tumor tissues, people naturally think: Can you directly use it with chemical drugs to accurately find cancer cells and give him a "total annihilation"? After all, no matter how hard you work, you are afraid of a kitchen knife: no matter how tough a cancer cell meets a high dose of chemical drugs, it will only disappear.

　

Schematic diagram of the action mechanism of antibody-coupled drugs

　

(photo: ADCREVIEW)▼

　

　

This is antibody-based coupled drugs (ADC), which is one of the main anticancer drugs at present.. The principle is simple, but there are many difficulties in research and development: how do protein primers connect with "toxins" that attack cancer cells? How to ensure that you don’t play your medicine too early on the way to the "enemy camp"? How to "exit" in case of entering normal cells of human body? As a result, ADC drugs with complex structures have become research and development black holes. Once the research and development fails, it is difficult to find out which link has a moth.

　

How to design the parts of antibody conjugates

　

It is a big problem to maximize the drug effect ▼

　

　

In the past, this was the natural technical moat of large multinational pharmaceutical companies, which could greatly increase the price of drugs; But now, this is still the stage for China pharmaceutical companies to show their fists:At the end of 2023, BL-B01D1, an ADC dual-antibody drug for lung cancer and breast cancer, was developed by Bailey Tianheng, which set a record for China drugs to go to sea. Successfully went to sea with a down payment of $800 million and a potential price of $8.4 billion..

　

China’s biomedical industry has not only quickly caught up with the world-class phalanx, but also achieved a leading position in some fields.

　

Bai Li Tian Heng represents China Biomedical Haoheng.

　

(Photo: Bai Li Tian Heng) ▼

　

　

Both PD-1 and ADC use drugs to enhance the immune cell ability of human body or kill cancer cells. Then, directly enhancing the recognition ability of human immune cells can also achieve anti-cancer effect? It sounds like science fiction, but it has been realized in reality: using genetic engineering technology to inject receptor genes that can recognize the corresponding tumor cell antigens into immune T cells, so that they can accurately identify cancer cells. This is the CAR-T cell therapy technology.

　

Process diagram of CAR-T cell therapy technology

　

(Photo: MUSC)▼

　

　

At present, CAR-T is mainly used for the treatment of hematological cancers, including well-known leukemia. There are only ten models on the market in the world, and China has four models, including Regiosai injection of Wuxi PharmaTech, which is heavily held by biomedical ETF. In addition to the treatments already on the market,There are hundreds of CAR-T therapies being developed in China, the largest number in the world..

　

China’s bio-pharmaceutical industry, which once could only follow the big international pharmaceutical companies, has finally grown up.

　

Reggiorense injection is the second CAR-T product approved in China.

　

It is also the first CAR-T product of Class 1 biological products in China.

　

(Photo: Wuxi PharmaTech) ▼

　

　

The overall progress of this industry is inseparable from the joint efforts of this huge industrial chain. The listing of any drug requires sufficient clinical trial evidence and approval of relevant departments. For a long time, the approval speed of new drugs and new medical devices in China is slow, and a large number of drugs to be approved often pile up. In the high-speed development of drug research and development track, any time delay will miss business opportunities.

　

Since August 2015, the State Council issued the Opinions of the State Council on Reforming the Examination and Approval System of Medicines and Medical Devices, and a series of reform measures have been introduced one after another. In 2019, the newly revised Drug Administration Law established the MAH system for listed licensors, which mobilized the enthusiasm of more new drug research and development. The response of the market and industry is also extremely rapid, and various breakthroughs of biomedical enterprises in China have emerged in succession.

　

The core of MAH system is to separate drug marketing license from drug production license.

　

Allow pharmaceutical production enterprises, R&D institutions or researchers.

　

Become an independent drug marketing license holder

　

(Photo: Drug Administration Law) ▼

　

　

Go out to sea and look to the future.

　

The breakthrough in the related fields of innovative cancer drugs is only one aspect of the rapid progress of the biomedical industry in China. With the deepening of people’s cognition, medicine is more than just taking medicine to see a doctor; The future medicine will be a whole from genes to society. The biomedical industry in China is also making all-round progress.

　

Biomedicine in China is making efforts.

　

(Photo: Yitu. com) ▼

　

　

Since the 21st century, people have made many breakthroughs in cancer treatment. But no matter how to treat it, it is a process of suffering for patients. It would be best if it could be prevented.

　

At present, the human papillomavirus vaccine (HPV) is the only vaccine that has an obvious preventive and therapeutic effect on cancer (cervical cancer). Originally, it was expensive and all of it relied on imports. Many cities were in short supply and even went to Hong Kong to fight. nowDomestic bivalent HPV vaccine has been put on the market, and the cost of vaccination has been greatly reduced..

　

Bivalent HPV vaccine independently developed and produced by watson biological.

　

A needle costs less than 400 yuan.

　

(Photo: released by Kunming) ▼

　

　

People’s recognition of domestic vaccines is real.Zhifei Bio and watson biological held by Biomedical ETF.They all rely on relevant vaccine products to achieve good results in the capital market. It can be expected that this market will continue to grow after the domestic nine-valent vaccine is listed around 2025.

　

▼

　

　

　

Under the constant technical update,The pharmaceutical industry will continue to reshuffle and opportunities will continue to emerge..

　

An unprecedented wave of aging has arrived, and the biomedical industry with long-term sustainable development potential is undoubtedly the biggest outlet under this trend. Houston Medical City has proved to us that this industry has unlimited potential and long-term stability, and it is also a great opportunity for the city to realize industrial transformation. For individual investors, this is a win-win choice to support national health and obtain stable investment income; For practitioners, the market is changing with each passing day, and there are many opportunities but fierce competition.

　

To win the hard bones in the field of medicine, we need to unite from policy to market, as well as various therapies and all directions. Various fields with great prospects will gradually merge into one. It should be only a matter of time before China has its own world-class medical center.

　

Swipe up and down to view references:

　

Arnold, C., Webster, P. 11 clinical trials that will shape medicine in 2024. Nat Med (2023).

　

Chau, C.H., P.S. Steeg, and W.D. Figg, Antibody-drug conjugates for cancer. Lancet, 2019. 394(10200): p. 793-804.

　

Hao
MM, Stamp LA. The many means of conversation between the brain and the
gut. Nat Rev Gastroenterol Hepatol. 2022 Dec 14. doi:
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Hu
Y M , Guo M , Li C G ,et al.Immunogenicity noninferiority study of 2
doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine
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Z, Chen Y, Liu D, et al. The landscape of cancer research and cancer
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Schuhmacher
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* The reference to individual stocks is for reference only and does not constitute investment advice.

　

* The content of this article is provided by the author and does not represent the position of the Earth Knowledge Bureau.

　

Cover: Yitu. com

　

END

　

　

First Electric learned from the public notice list of new vehicle products in Road Motor Vehicle Manufacturers and Products (No.356th batch) published by the Ministry of Industry and Information Technology that Genie #1 will soon launch a dual-motor version, and Deep Blue C385 (code name) was officially named Deep Blue SL03, and a brand-new brand LOGO was released. The sports kit of UNI-V iDD was really awesome. We selected seven new cars to recommend from this batch of declaration catalogue.

1. Should it be said that this is a girl’s favorite electric car? Two-motor version of Genie #1

The catalogue of the Ministry of Industry and Information Technology shows six models of Elf #1. Needless to say, the appearance can be summarized simply by the word "good-looking". Different from before, the Ministry of Industry and Information Technology showed the power of the Genie #1 dual-motor version, with the maximum power of 115kW and 200kW before and after respectively, and the total power of the motor was 315kW.

Genie #1 locates compact SUV,The length, width and height of the car body are 4270mm, 1822mm and 1636mm, respectively, and the wheelbase is 2750mm, which is based on the vast pure electric structure of SEA., designed and developed by Germany.

As a pure electric vehicle, Elf #1,It is equipped with a ternary lithium battery with a capacity of 66 kWh. At the time of pre-sale, the official claimed that the maximum pure electric cruising range could reach 560 kilometers (CLTC China light vehicle driving condition).In the DC overcharge mode, the power can be increased from 10% to 80% in less than 30 minutes.

The single-motor version of Elf #1 is equipped with a permanent magnet synchronous electric drive with a maximum power of 200kW and a peak torque of 343 Nm. It only takes 6.7 seconds to accelerate from standstill to 100 kilometers per hour, and its powerful power is also one of the characteristics of Elf #1.

Therefore, the double-motor version of Elf #1 is coming, and the power will be more powerful. The adjective "small steel gun" is no longer suitable for the double-motor version of Elf #1.

2. Exchangeable geometry E

Geometric e is the fourth product of geometric automobile, with the length, width and height of 4006mm, 1765mm and 1550mm respectively, and the wheelbase of 2485 mm. According to the previous news, the car will provide two different cruising ranges, namely 320km and 401km, corresponding to the battery packs with battery capacity of 33.5 kWh and 39.4 kWh. So how big a battery pack will this geometry E that can support power exchange carry?

In terms of power, Geometry E will be equipped with a permanent magnet synchronous motor with a maximum power of 60kW, a peak torque of 130N·m and a maximum speed of 121 km/h..

The front face design of Geometry E is very recognizable. The front face is integrated with a three-dimensional geometric graphic light group. The headlights are sleek in design and decorated with circular plaques around the headlights. The use of color in details is still very popular. The car is also equipped with IHBC intelligent high beam control function, which can realize the automatic change of far and near lights with the scene.

3. Deep Blue C385 was renamed Deep Blue SL03.

Deep blue C385 declaration news exposure,The official name of the new car and the deep blue series LOGO were released together., Deep Blue C385 will be named "Deep Blue SL03",The brand Logo will adopt the design of "energy crystal".

Pure electric vehicles are divided into two versions, 160kW and 190kW respectively., equipped with lithium iron phosphate battery (Contemporary Amperex Technology Co., Limited) and ternary lithium battery (Chongqing New Energy Automobile Technology Co., Ltd.), the power consumption is as low as 12.3 kWh /100 km. According to the news exposed before, C385 electric version.The longest battery life can reach more than 700 kilometers, and the fastest time is 5.9 seconds..

Extended range version, equipped with deep blue SL 03Power system consisting of 1.5-liter engine and motor.The maximum power of the engine is 70kW, the maximum power of the motor is 160kW, and it is equipped with lithium iron phosphate battery from Zhongchuang Singapore Airlines. Under CLTC comprehensive working conditions,The pure electric cruising range is over 200 kilometers, and the comprehensive cruising range is over 1,200 kilometers.The fuel consumption is as low as 4.5L/100km, and the maximum speed can reach 170km/h..

4. Weilai NT2.0 pure electric platform, exposed by Weilai ES7 Ministry of Industry and Information Technology, with 480kW dual motors.

The length, width and height of Weilai ES7 are 4912mm, 1987mm and 1720mm respectively. Thanks to the support of Weilai NT2.0 pure electric platform, the wheelbase has reached 2960mm, and the whole vehicle is defined as a pure electric medium and large SUV. Weilai ES7 continues to adopt the latest Weilai family-style X-Bar design language, with angular ridges on the hood and the shape of SHARK NOSE’s front face, which looks very unique.

Weilai ES7 is also equipped with laser radar, which is similar to Weilai ET7 in design. The laser radar is installed at the front end of the central line of the roof, and both sides of the front end are also equipped with high-position cameras, which have NAD safety and driving assistance functions and have high automatic driving ability.

The appearance of Weilai ES7 can be selected in many ways, among which the hub has three sizes, namely 255/55 R19, 255/50 R20 and 265/45 R21. In addition to the wheel hub size, even the brake calipers can be selected in red, black and silver.

In addition, the trademark color, hubcap color and tail logo of Weilai ES7 can be personalized. At the same time, the front and rear lower decorative boards and side decorative boards of Weilai ES7 have a variety of choices for users to choose, helping users to create personalized ES7 appearance.

In terms of performance, Weilai ES7 and ET7 use the same powertrain. The power of the front and rear double motors is 180kW and 200kW respectively, and the total power reaches 380kW. The battery system is still from Contemporary Amperex Technology Co., Limited, and the specific battery capacity has not been announced.

In terms of pricing, as a high-end pure electric vehicle brand in China, Li Bin once said: "We will still stick to our high-end market positioning. Simply put, how much is the oil car sold, and our tram sells the same price." Weilai ES7 is positioned between ES6 and ES8. It is estimated that the starting price will exceed 400,000 yuan, and its competitors are locked in domestic products and GLC. According to the official information disclosed by Weilai, Weilai ES7 will be officially released at the end of May, and delivery is expected to begin within this year.

5. Huawei asked the M7 dual-motor version to come.

The extended-range version of Wujie M7 dual-motor is registered in the catalogue of the Ministry of Industry and Information Technology. The color of the black version is more attractive. The overall appearance basically continues the design language of Wujie M5, and it is equipped with a large-size air intake grille, which gives people a calm and practical feeling. Rectangular front fog lamps are also used on the left and right sides of the grille. Optional rim shape, bright window frame and rear bumper.

On the side of the car body, the new car adopts a hidden handle design, and the rear row is equipped with privacy glass. A penetrating taillight has been installed at the rear of the vehicle, and it is inlaid with the signs of "Jiejie M7" and "Sailis". Body size, the length, width and height of M7 are 5020mm, 1945mm and 1775mm respectively, and the wheelbase is 2820mm.

In terms of power, this dual-motor extended-range version is equipped with a 1.5T four-cylinder turbocharged range extender drive with a maximum power of 92kw and a drive motor with a rated power of 65kW/72kW.The peak power is 130kW/200kW,Equipped with battery pack provided by Contemporary Amperex Technology Co., Limited, the fuel consumption of WLTC is 1.09L/100km.While allowing external charging.

6, UNI-V iDD exaggerated sports kit, simply don’t be too handsome

From the declaration of UNI-V iDD in the Ministry of Industry and Information Technology, the appearance continues the design of gasoline version, with borderless grille on the front face and deep air inlets on both sides. The side of the car body is designed with a dynamic V-shaped surface, and the back-sliding shape also has a hidden door handle and electric tail design. The sense of technology and fashion is very competitive in the same class.

In terms of body size, the length, width and height of the new car are 4680/4695mm, 1838mm and 1435mm respectively, and the wheelbase is 2750 mm. UNI-V iDD has two kinds of car lengths, and we guess this is related to the optional sports enveloping kit.

In terms of power, it is equipped with a motor with a maximum power of 125kW, and the maximum net power of the engine is 122kW. In terms of battery life, the comprehensive battery life of the new car will reach more than 1100km, the pure battery life will exceed 130km and external charging is allowed.

7. Wei Pai’s dream has created a precedent for retro SUV modeling?

The application information of the new medium-sized SUV of Wei brand. The new car continues the retro design style of the concept car and will use the DHT plug-in hybrid system. It is reported that the new car will be officially launched in the second quarter of this year.

It first made its debut at the Guangzhou Auto Show in 2021. Different from other models on the market, Wei’s dream has adopted a classical style, which is officially called "a new generation of retro tide driving". In terms of power, the new car is equipped with a hybrid system composed of 1.5T+ motors.

The length, width and height of the Dream are 4830mm, 1995mm and 1725mm, respectively, and the wheelbase is 2915mm, which belongs to the category of medium-sized SUV in terms of size. Headlights are set on the protruding front fender, and the round headlight style is both retro and cute enough.

The back-sliding tail also adopts a prominent tail box design. With oval rearview mirror, chrome trim on the front fender and chrome door handle, the details further emphasize the retro design aesthetics. The rear taillight group adopts a simple oval design and is decorated with LED light sources, which is not lacking in practicality in retro.

This time, the Ministry of Industry and Information Technology showed that the rear window, rearview mirror and even the wheel hub size of the Wei brand dream model can be optional, and different shapes can create a personalized retro appearance.

In terms of power, Yuanmeng will be equipped with a DHT plug-in hybrid system. The engine used is a 1.5T engine with model E15BD, and its maximum power is 115kW(156 HP). At the same time, the new car will also provide two driving forms: two-wheel drive and four-wheel drive according to the configuration.

9. Zhang Xinyi

　　Tik Tok Zhang Xinyao is also a red man, and his popularity in Tik Tok has been very high. In fact, compared with other handsome little brothers, Zhang Xinyao is not outstanding in appearance, with a single eyelid and small eyes. If you look at it alone, it is still a little general, but it is also a major feature of him that he has considerable affinity. And my little brother is still in’ 94, coquettish and cute. There are many people who can dance and grow handsome, but there is only one like Zhang Xinyao. When he smiles, the whole world lights up, and he always feels that his eyes are sweeter than the corners of his mouth.

10. Lianyin Society

　　Before the fire of Modern Brothers, the music club was also on fire for a while, that is, the heat has dropped again recently. Lianyin Society is also popular because it sings beautifully. Every live broadcast is also surrounded by three floors inside and three floors outside. Lianyin Society’s "Lesions" and "Leaving People" are quite classic. The classic combination of Lianyin Society, one fat and one thin, is also very distinctive. One is responsible for the lead singer and the other is responsible for the RAP part. Gold always shines. I hope Lianyin Society can continue to cheer in Do not forget your initiative mind!

　　[car home Information] The five-day losing streak ended, and the domestic auto market ended successfully in 2021. As an annual review and summary, car home continued to launch the "Inventory 2021" series, deeply disassembling the annual answers of major brands. The first issue of "Inventory 2021" focuses on China brand, and reviews with you the high-quality report card of China brand, whose market share reached 40% for the first time in 2021.

　　Note: The analysis of "Inventory 2021" series is all based on the insurance sales data of new cars of China Insurance Regulatory Commission.

　　Sales rose by 26.5%, with a market share of nearly 40%.

　　In 2021, the domestic sales of new cars reached 21.3436 million, ending the five-day losing streak and increasing by 6.33% year-on-year. Among them, the sales volume of China brand new cars reached 8,464,400. After four consecutive years of decline, the headwind turnover rose by 26.5% year-on-year, and the market share reached 39.66%, which was the best achievement in history. Previously, the market share of China brand cars exceeded 30% for the first time in 2016, and has been hovering around 33% ever since.

　　New energy to help overtake 40% is not a dream.

　　SUV is still the dominant category of China brand cars, with annual sales of 4,596,800 vehicles, accounting for 54.3% of China brand new cars, and accounting for 46.8% of the entire SUV market, more than twice that of Japanese SUVs and German SUVs; The annual sales volume of cars is 2,924,700, accounting for 29.1% of the whole car market, slightly lower than that of German cars and higher than that of Japanese cars.

　　Why did China brand cars turn over against the wind? The answer is the continuous expansion of new energy vehicle consumption.

　　In 2021, the monthly sales volume of China brand fuel vehicles has been below 500,000, but new energy vehicles have continued to grow, especially pure electric vehicles. In 2021, China brand pure electric passenger cars sold 1.92 million vehicles, accounting for 80.3% of the total domestic pure electric vehicles; Plug-in hybrid vehicles sold 389,000 vehicles throughout the year, accounting for 71.1% of the corresponding market. China brand has been firmly established as the "home position" of domestic new energy vehicles.

　　The continuous growth of new energy vehicle sales has changed the product pattern of China brand cars. In 2021, the sales of pure electric vehicles accounted for 22.7%, which broke through 20% in June, and then increased all the way, reaching more than 30% by the end of the year. In the whole year, the new energy utilization rate of China brand passenger cars reached 27.3%, which is a very high proportion. The activity of the market has inspired the optimism of forecasting institutions. The Association has set the sales volume of new energy passenger cars at 5.5 million in 2022, and doubled it on the basis of 2021.

　　Brand Top 20: two new forces enter the list WEY/ Pentium/BAIC exits.

　　Let’s look at the most watched brand rankings. We have listed the annual Top 20 list of China brands (Friendly reminder: The following list is worth your more attention.), the annual sales of these brands are basically above 100,000 vehicles.

　　According to the market scale, it is roughly divided into three echelons: the first echelon is five head brands with annual sales of more than 700,000 vehicles, followed by Geely Automobile, Changan, Wuling Automobile, Haval and BYD; The annual sales volume of the second echelon is more than 200,000 vehicles, and there are seven brands including Chery, Roewe, Guangzhou Automobile Chuanqi and Hongqi. The sales volume of the third echelon is 90,000-200,000 vehicles, including 8 brands such as Euler, Jetway, dongfeng fengshen and Guangzhou Automobile Ai ‘an.

　　Judging from the rising trend of various brands, BYD, Euler, Tucki, LI and Weilai all increased by more than 100% annually, among which Tucki increased by more than three times and LI nearly doubled. Regrettably, among the three new head forces, Weilai, who made the earliest effort and delivered the earliest mass production, did not make the list, ranking only one place in the 21st.

　　As a result of the annual brand qualifying competition, the three leading new car-making forces made great strides forward-Tucki ranked 18 th and advanced 123 places; LI ranked 19 th and advanced 10 places; Wei Lai ranked 21st, advanced 3 places, and Euler also advanced 10 places. If there is progress, there will be progress. In 2020, Qichen, Pentium, Jianghuai, WEY and BAIC, which ranked in the last five on the Top 20 list, fell out of the list in 2021, which is exactly what the waves behind the Yangtze River pushed forward.

　　Let’s open the transcripts of the top students below.

　　　5 major head brands are detailed.

　　　Geely Automobile: the only China brand with over one million yuan.

　　The annual sales volume of Geely Automobile is 1,052,600 vehicles, which is 4.55% higher than that of 2020. It still maintains the position of the first brand in China, and it is also the only China brand with annual sales volume exceeding one million, ranking fourth in the annual brand list. Although it is still far from Volkswagen and Liangtian, it has surpassed Nissan.

　　The best three cars sold by Geely are (|), Bo Yue and Xingrui, with annual sales of 167,000, 162,000 and 114,000 respectively, of which Emgrand’s annual growth rate reached 24.2%, Bo Yue decreased by 8.4%, and the monthly sales of Xingrui listed in October 2020 has exceeded 10,000.

　　Emgrand has been listed for many years, and derived Emgrand L, Emgrand S, Emgrand GL (discontinued) and corresponding new energy vehicles. The sales volume of Emgrand in 2021 reached 278,500, and the monthly sales volume basically remained at 20,000+.

　　In terms of power type, Geely brand is still dominated by fuel vehicles, with annual sales of 1,016,200 vehicles, while the sales of pure electric vehicles are only 26,500 vehicles, with less than 10,000 vehicles mixed, and 838 methanol vehicles.

　　If we look at the whole Geely Group, the strategies of its brands are different. For example, Lectra focuses on the young market, and the main models are basically "fuel vehicles+plug-in models" partners. Extreme Krypton focuses on the electric market. As of December, the cumulative sales volume of ZEEKR 001, the first medium and large pure electric car of Extreme Krypton, was 5,737. Whether Krypton can make Geely Group open a new world in the electric market and help Geely continue to attack Honda remains to be tested.

　　Chang ‘an: Is New Energy Left Behind?

　　Changan’s annual sales volume was 932,800 vehicles, up 14.19% year-on-year. China brand echelon ranked second, ranking sixth in the overall list, with a gap of less than 110,000 vehicles compared with Nissan.

　　Changan’s Hua Dan is Changan CS75 PLUS, with annual sales of 275,000 vehicles, which is basically the same as that of the previous year. It is the runner-up in compact SUV sales and the most taboo product of Haval H6, with the current monthly sales of 23,000+.

　　Yidong, the China brand compact car with the highest sales volume, sold more than 170,000 cars in the whole year, slightly more than Emgrand; Another compact SUV, Changan CS55PLUS, is its third-selling model, with annual sales of 141,000 vehicles.

　　UNI series sold a total of 117,000 vehicles in 2021, including 84,000 vehicles sold by UNI-T and 33,000 vehicles sold by Uni-K.. Changan UNI-V has started pre-sale and will be listed in the first quarter of this year.

　　In terms of product power types, Changan’s fuel vehicles sold 837,100 vehicles and pure electric vehicles sold 95,500 vehicles throughout the year, basically supported by a mini-car of Benben -E-Star. At present, Changan has not launched an independent new energy source, but at the end of 2021, it joined hands with Huawei, Contemporary Amperex Technology Co., Limited and Weilai to launch Aouita, a brand of "high-end intelligent electric vehicle".

　　Wuling: the low-priced car king refuses to accept it.

　　Wuling Automobile sold 930,400 vehicles annually, with a strong increase of 58.6%, ranking third in the brand list of China and seventh in the overall list. Hongguang MINIEV, like howard the duck, is not only the "hero" of Wuling, but also the annual sales king of China brand new cars, which evokes the "second spring" of the domestic mini-car market.

　　Wuling is definitely a brand that honestly carries out the low-price strategy. The annual sales of 930,400 vehicles are mainly supported by these cars. You can see it at a glance-

　　Hongguang MINIEV, with an annual sales volume of over 390,000 vehicles, surged to 46,000 vehicles in December, which is definitely half of Wuling brand; The second largest is Wuling Hongguang, with an annual sales of 194,000 vehicles; The third is Wuling Hongguang V, with an annual sales of more than 90,000 vehicles, and the compact MPV Wuling Capgemini has an annual sales of 62,200 vehicles. Three cars below 50,000 yuan account for 3/4 of its annual sales.

　　Attracted by the explosion of Hongguang MINIEV, the domestic mini pure electric market also broke out again in 2021, with more than 40 models on sale, but there is no difference between products and there is obvious convergence. Judging from the market performance, Hongguang MINIEV "has been imitated, but has not been surpassed yet", and half of the mini-car market has been eaten by Hongguang MINIEV. Except Hongguang MINIEV, no China brand car has a monthly sales volume of more than 40,000.

　　 Haval: Really don’t consider the new energy SUV?

　　In 2021, Haval achieved a sales volume of 738,000 vehicles, a slight increase of 2.34% over the previous year, lagging behind the overall automobile market, and dropped one place on the list, from the third place in the previous year to the fourth place. Haval is also the lowest annual growth rate among China brands. Considering that Harvard introduced a series of new cars named after animals in 2021, this growth rate is even more "gold content" insufficient.

　　Haval H6 is still the main force, with annual sales of 356,000 vehicles, an increase of 3.4%, accounting for almost half of the brand’s annual sales; Haval M6 sold 144,000 vehicles, down 6.4%. The annual sales volume of Haval Big Dog also exceeded 100,000 vehicles, making it one of the "three-legged" brands supporting Haval, and its monthly sales volume has exceeded 10,000, which is the earliest debut in Haval’s "Zoo Series" and the best one currently sold.

　　Haval Beast, which shoulders the heavy responsibility of brand promotion, quality promotion and tide wisdom promotion, and tries to break the existing cognition of H6, is the least H6-like model of Haval. It sold 5,662 vehicles in December shortly after its launch.

　　In fact, Haval’s main models can basically be regarded as all kinds of changes or derivatives of the new and old H6, which makes its products have various changes in appearance, and the interior/entertainment/intelligence is also extremely differentiated, but in the end, the feedback to the consumer cognition level has little differentiation. After desperately "having children", the Great Wall needs to think about how to "raise children".

　　As the main brand of Great Wall Motor, Haval has not taken any action in the field of new energy. Great Wall has also laid out pure electric vehicles in Euler and Mechanon, and laid out hybrid vehicles in WEY. Euler’s annual performance has also submitted an excellent report card to Great Wall. In the face of the lack of growth of the Harvard brand, does the Great Wall really not consider letting new energy sources "save"?　　　

　　BYD: DM-i was a hit.

　　Finally came to BYD. BYD recorded a sales volume of 720,300 vehicles in 2021, with 17,000 vehicles just behind Haval, ranking fifth in the China brand list.

　　From the perspective of monthly sales, BYD is the only brand that continues to climb. There is no trough in a year, that is, it attacks all the way. BYD is also a brand of plug-in hybrid and pure electric. In the whole year, pure electric vehicles sold 297,000 vehicles, plug-in hybrid vehicles sold 229,000 vehicles, and fuel vehicles were a minority, with only 194,000 vehicles.

　　BYD achieved a record in 2021 with the assistance of blade batteries and DM-i models. The highest sales volume of bicycles is Han, with the annual sales volume of 109,000 vehicles, ranking fourth in the annual list of medium and large cars, which is the first time that China brand cars have achieved the best results in this market segment. The annual sales gap between Han and Mercedes-Benz E-Class is 44,000 vehicles. Do you think this gap will narrow in 2022? Expand? Or fill it in?

　　Let’s set a straight face here.At present, many articles say that the annual sales volume of Qin PLUS DM-i exceeds 190,000 vehicles. In fact, this figure is the annual wholesale sales volume of the entire Qin family, including oil trucks. It is not the achievement of Qin PLUS DM-i, after all, it has only been on the market for 10 months. According to the traffic insurance data, in 2021, the sales volume of the entire Qin family was 171,331.

　　Unfortunately, as of press time, we have not been able to separate the specific sales volume of Qin PLUS DM-i, but based on the monthly sales volume, the annual sales volume should be above 80,000, and the highest monthly sales volume is close to 15,000. Therefore, the new energy sources of Han, Qin PLUS DM-i and Song PLUS should be the top three cars of BYD.

　　Although BYD ranked 5th in the whole year, its insurance sales in November ranked first in China brand, and ranked second in December. With the heavy volume of a number of new cars, especially DM-i series models, BYD’s ranking will definitely go up again next year. Anyway, Harvard is afraid it can’t stand it.

　　Pursuing victory and inciting the new market of high-end intelligent electric vehicles

　　The record of China brand in 2021, especially the rapid development of new energy vehicles, has once again sounded the drum of brand promotion. This year, China car companies seem to have found the same way: to launch a new brand with a golden spoon, which is independent from the mother’s fetus, so as to reinvent itself and create a brand-new high-end image.

　　Geely introduced Krypton, Dongfeng introduced Lantu, and Zhiji of SAIC, Salon of Great Wall and Aouita of Chang ‘an all came out in 2021, and set up a new brand, reinventing themselves and rushing to the high end-this is a highly consistent tactic of many car companies at present.

　　Most of the technical routes of these high-end new brands focus on the electric and intelligent next-generation cars, and in product strategy, they focus on high-end cars with a price of 300 thousand to 400 thousand. However, the high-end password in the electrification era and the fuel era are no longer in a thinking paradigm. So what’s the secret of winning at this new track? This is the next major proposition of China brand.

　　Editor’s comment:

　　China brands have always hated low-grade products with a market share of less than 30% and the occupation of fourth-and fifth-tier cities. However, the situation changed in 2021. Although the term "overtaking in corners" is no longer in the mainstream discourse system, the performance of China brand in 2021 seems to verify this former vision. This year, China brand made collective efforts on the new energy track, and began to seek high-end and advanced again. After the headwind, how can it continue to be born in the sun? In 2022, the answer will be given.

　　Then, we might as well make two guesses here: First, will BYD surpass Haval? Second, it has surpassed Han in lexus ES. Will it surpass Mercedes-Benz E-Class in the future? (Text/car home Wang Jingbo)

　　Recently, Guiyang citizens rushed to queue up to buy ham moon cakes from Guizhou Provincial People’s Hospital. Some netizens said that "it takes four hours to queue up to buy provincial medical moon cakes". The staff of Guizhou Provincial People’s Hospital responded to the Beijing Youth Daily reporter, and there were exaggerated elements in the online segment. Mooncakes sold in hospitals are sold all year round.

　　Hospital cloud leg moon cake becomes "online celebrity"

　　On September 29th, a netizen posted, "The mooncakes made by Guizhou Provincial People’s Hospital are very delicious. I came to the hospital at two o’clock in the morning to queue up to buy mooncakes, but I found that there were hundreds of people waiting in line, and the scene was comparable to that of Spring Festival travel rush." As can be seen from the picture, the queue to buy moon cakes is tens of meters long, from the canteen sales point on the side of the hospital to the pediatric emergency door. Some netizens said that this team "can circle the earth several times." On the afternoon of September 29, the staff canteen issued a notice saying that due to the limited processing capacity of moon cakes, each person was limited to 10 kg. Please forgive me.

　　Mr. Hu, a surgeon at the People’s Hospital of Guizhou Province, told the reporter of Beiqing Daily that moon cakes only have a taste of cloud legs, and there is honey in the stuffing. The taste is soft, sweet and salty. "The moon cakes are delicious when they are baked. We can smell the moon cakes in the canteen on the first floor on the 20th floor." Mr. Hu said that every Mid-Autumn Festival, the hospital will issue a mooncake supply ticket to employees, and each person can get 5 kg of mooncakes with the ticket, but employees have to queue up to get mooncakes.

　　Waiting in line is hot, giving birth to "purchasing"

　　The reporter of Beiqing Daily noticed that in the pictures provided by netizens, it can be seen that there are a large number of SF Express boxes at the entrance of the hospital cafeteria. In this regard, the surgeon Mr. Hu said that the hospital has never entrusted any organization to deliver moon cakes, but because moon cakes are widely welcomed by the public, SF Express opened a courier point next to the hospital to help the public deliver them.

　　Mr. Li, a citizen, told the reporter of Beiqing Daily that the moon cakes in hospitals are in short supply, and there are people who come to help relatives and friends purchase them, as well as street merchants who sell "moon cakes for provincial doctors". "Don’t worry about queuing up to buy it yourself. I also bought 10 Jin for my relatives this year. They are not in Guizhou, so I sent it to them by express delivery to let them feel the atmosphere of the holiday at home." Mr. Li told the reporter of Beiqing Daily.

　　In this regard, the staff of the hospital staff canteen said that moon cakes and cakes were prepared for hospital staff and their relatives. Except for the staff canteen and Shengyi restaurant opposite the hospital, the "provincial medical moon cakes" sold by other businesses were not from the hospital.

　　Hospital: There are exaggerated elements in the online segment.

　　The surgeon Mr. Hu told the reporter of Beiqing Daily, "The moon cakes in the hospital are really hot. When I got off work at 11 o’clock last night, I also saw many people waiting in line. But the hospital doesn’t make moon cakes to attract attention. Our family has been practicing medicine for two generations. I was born here and grew up here, and now I have worked here for two years. In my impression, the hospital has been making moon cakes for more than ten years, which is also a feature of the hospital. "

　　The reporter of Beiqing Daily contacted the Propaganda Department of Guizhou Provincial People’s Hospital. The staff said that the hospital sold daily cakes made by the catering department of the staff canteen. It is widely praised for its fresh ingredients and freshly made cakes, but it is sold all year round, not just in the Mid-Autumn Festival. Queueing is spontaneous by citizens. Weibo’s joke "Queueing around the earth several times" is exaggerated, and "The turnover of moon cakes in hospitals exceeds 200 million" is also out of thin air. Text/trainee reporter Zhang Xi