Text: the sound of trees and grass in the forest

　

Proofreading: Chao Gan/Editor: Guo Licheng

　

Houston, an American city no stranger to China, is well-known for its rocket team and space city. People are deeply impressed by its developed petrochemical industry, staggered pipelines and busy factory ports.

　

There are more than rockets and oil behind Houston’s prosperity.

　

(Photo: shutterstock)▼

　

　

But to say that Houston’s most prosperous industry, it has to be the following:

　

The annual output value is as high as $14 billion, more than 90,000 people go to work, and many top medical institutions and researchers gather. By the way, one of the largest medical complexes in the world supports a quarter of Houston’s hotel business.Dezhou medical center.

　

Texas Medical Center "supported" a city on its own.

　

(Photo: Yitu. com) ▼

　

　

This achievement of Texas Medical Center was not achieved overnight, but was a leader in the industrial transformation of the United States for decades. Due to the large number of well-known hospitals gathered here, the supporting medical equipment, industry exhibitions, health consultation and other industries have also developed.

　

Compared with today’s depressed Great Lakes rust belt, Houston is still full of vitality.

　

Industrial explosion in the aging era

　

Houston’s success in the pharmaceutical industry, on the one hand, benefits from the strong strength of universities, scientific research and talents, but as an industry, the most fundamental reason for its rise is stillFundamental transformation of social population structure.

　

76 million people were born in the "baby boom" in the United States from 1945 to 1964, and the average age of the American population has been rising since then. Despite the continuous immigration supplement, compared with the obviously increased elderly population, the incidence of a series of diseases such as diabetes, cancer and Alzheimer’s disease is bound to increase, and the pharmaceutical market is bound to expand.

　

The baby boomers are getting old.

　

Directly raised the average age of the American population ▼

　

　

Aging is not exclusive to Europe and America.With the inevitable trend of economic development and fertility decline, China is no exception.. Moreover, China people’s awareness and demand for health are also obviously improving, which can be seen from the financial market: in the past 20 years, the pharmaceutical and biological industries have increased sevenfold, ranking among the top five in all industries; The scale of biomedical ETF(512290) is also rising step by step.

　

The pharmaceutical and biological industries are growing rapidly ▼

　

　

Biomedical ETF▼

　

　

In the age of aging, diabetes and obesity have become a problem that almost everyone has to face. At present, there are about 537 million people with diabetes in the world aged 20-79. Nowadays, the sale of all kinds of sugar-free drinks and foods on the market is a manifestation of people’s worries.

　

The treatment of diabetes, a chronic disease, is a worldwide problem. Otherwise, there will be no so-called "ancestral secret recipes" flying all over the sky. However,The emergence of GLP-1 drugs will be a blessing for patients..

　

GLP-1 (human glucagon-like peptide -1) is a protein secreted by human intestinal cells, which can promote human insulin secretion. However, GLP-1 secreted by human body is easy to be decomposed by other enzymes, and will not act for a long time. Then, if we improve the structure of GLP-1 so that it is not easy to be decomposed, won’t it promote insulin secretion for a long time and treat diabetes?

　

▼

　

　

Science magazine listed the related research of GLP-1 as the top ten scientific breakthroughs in 2023.Among them, the most famous drug is undoubtedly Smegliptide, which has occupied half of the field of diabetes..

　

(Note: At present, this drug is only approved for the treatment of diabetes in China, but it has not been approved for weight loss! )

　

Smegliptide also shows great potential in the prevention and treatment of Alzheimer’s disease, nonalcoholic hepatitis, cancer and kidney disease, and it is quite aspirin-like "cure all diseases". In October last year, after Novo Nordisk announced the "positive experimental results" of smegliptide in the treatment of diabetic nephropathy, the share prices of many dialysis manufacturers fell. And this story has happened many times in the medical field.

　

The announcement shows that the efficacy of smegliptide has reached the expectation.

　

Therefore, the experiment was terminated early ▼

　

　

Lilly, a pharmaceutical giant, was originally a small company, but relied on its keen sense of smell to take the lead in obtaining insulin patents and monopolize the global market. However, in the 1980s, Novo Nordisk insulin injection pen went on the market, and this convenient and easy-to-use product sold well when it went on the market, which opened the era of hegemony in the diabetes drug market.

　

All these remind people that technology is constantly reshaping this market.An innovative achievement may create a new giant.; Another case is the wave caused by the listing of oral version of smegliptide in China in early 2024.

　

The oral version is also only approved for diabetes treatment.

　

Not approved for general weight loss!

　

(Photo: National Medical Products Administration) ▼

　

　

Massive capital investment and endless new achievements have created a vibrant biomedical industry today. In the past few decades, China, the fastest growing economy in the world, actually has a long-term shortcoming in the biomedical industry.Can you make up this short board?

　

China medicine, difficult to move forward.

　

Taking medicine when you are sick is something that everyone has to experience. However, the expensive drug price has become a pain in patients’ hearts. The dilemma in Dying to Survive may happen to each of us.

　

The reason why the drug price is so high is related to the current high cost of drug research and development:10 years, 1 billion dollars. For a long time, the pharmaceutical industry has been dominated by a group of large multinational pharmaceutical companies. On the one hand, it has high research and development costs and technical barriers. On the other hand, monopoly status means strong pricing power. Such a market situation has created amazing profit margins for large pharmaceutical companies: in 2023, the annual sales of smeagoutide reached $21.142 billion.

　

Novo Nordisk Meglumine Peptide Related Products Financial Report ▼

　

　

The pharmaceutical industry in New China originated from the eldest son of the Republic medicine-Shijiazhuang Huabei Pharmaceutical FactoryThe first batch of domestic penicillin in China was born here. However, due to our late start and weak foundation, we have never had any industrial advantages except for traditional Chinese medicine products with local characteristics for a long time. When foreign pharmaceutical companies with strong R&D strength and mature business model enter China, they are like wolves in the flock. If they don’t catch up, the pharmaceutical market of more than one billion people will be completely lost.

　

Chinese medicine is a symbol of moderns in Shijiazhuang ▼

　

　

At that time, China’s R&D ability was very weak, so we could only start with the production of basic raw materials for drugs. The ingredients of the raw materials are fixed, and the production process is relatively mature. As long as you are willing to do it, you can produce products. But the middle and lower reaches of this international industrial chain can receive a large number of orders only because of low labor costs. Moreover, the technological level was limited at that time, and the pollution in the production process was very serious.

　

This is obviously not a long-term solution. The vast market of all kinds of new drugs attracts China enterprises. Since they can’t make high profits in developing new drugs, let’s start with generic drugs and get a slice of the huge market first. Nowadays, many backbone enterprises in the pharmaceutical industry in China (such asHengrui Pharma, the heavyweight stock of biomedical ETF), it is in these two waves that the initial accumulation has been completed and it has moved to the upper reaches of the industrial chain.

　

From generic drugs to self-developed drugs

　

Enterprises need a certain amount of time to accumulate and precipitate.

　

(Photo: Picture Worm Creativity) ▼

　

　

At this time, the pharmaceutical industry in China has made great progress. But after all, I still follow in the footsteps of others, and I only earn a fraction of the big international pharmaceutical companies. If you really want to gain a foothold in the biomedical industry, you need to come up with your own things and change the old thinking and industrial model as a whole.Only by thoroughly remoulding oneself can we really grow up.

　

It is not only an economic and commercial issue to enlarge the local pharmaceutical industry. Even in the era of high globalization, the regional differences of health problems in different countries need the developed biomedical industry in their own countries.

　

For example, the Texas Medical Center mentioned at the beginning

　

Has the largest cancer center in the United States

　

(Photo: MD Anderson)▼

　

　

For example, due to the differences of environment and living habits in different countries, the incidence of cancer, the big health killer in the aging era, is different in different countries. The incidence of lung cancer and nasopharyngeal carcinoma in China is obviously higher than that in Europe and America, and esophageal cancer patients account for half of the world. Only by establishing an independent biomedical industry system can we better provide targeted treatment for patients.

　

Make your own medicine

　

Cancer, in most people’s minds, is equated with terminal illness. But the progress of modern medicine is enough to make this an old yellow calendar.

　

One of the major difficulties in cancer treatment is that cancer tissue has a strong ability to deceive, and it will "hide" itself under the guise of the identification mechanism in the human immune system to prevent cannibalism. In other words, if drugs can be used to "remind" the immune system and "catch the mole", it can play a role in preventing and treating cancer.

　

"There is a mole, terminate the transaction."

　

(T cells surround identified cancer cells)

　

(Photo: NICHD/J. Lippincott-Schwartz)▼

　

　

Research in this field has been carried out for decades, among whichPD-1/PD-L1 has attracted much attention from scientists.. Cancer cells will suppress T cells through this in vivo inhibitor, making it think it is a "friendly army". Scientists have developed drugs to block the inhibitory signal pathway between T cells and tumor cells, so as to "restart" the human anti-cancer mechanism.

　

Microscopically, PD-L1 positive lung adenocarcinoma cells

　

(Photo: wiki)▼

　

　

Such drug development requires high technology and in-depth study of human immune system. In the past, it was estimated that multinational pharmaceutical companies developed and sold high prices, and then domestic pharmaceutical companies waited for the patent period to pass a wave of imitation. However, times have changed.

　

By the end of 2023, 17 PD-(L)1 products have been approved for listing in China market, of which more than half are domestic products. In addition to PD-1 target, drugs such as PARP and CDK4/6 have also been successfully developed. Hengrui Pharma is one of the most important manufacturers in this field in China. Its biopharmaceutical products cover lung cancer, nasopharyngeal carcinoma and other high-risk cancer categories in China, and a large number of drugs are in the clinical research stage.

　

Some cancer-related drugs in Hengrui Pharma.

　

(Photo: Hengrui Pharma) ▼

　

　

But at present, the human response rate of PD-(L)1 drug is not high enough, and scientists are still improving it.

　

Since antibodies can recognize tumor tissues, people naturally think: Can you directly use it with chemical drugs to accurately find cancer cells and give him a "total annihilation"? After all, no matter how hard you work, you are afraid of a kitchen knife: no matter how tough a cancer cell meets a high dose of chemical drugs, it will only disappear.

　

Schematic diagram of the action mechanism of antibody-coupled drugs

　

(photo: ADCREVIEW)▼

　

　

This is antibody-based coupled drugs (ADC), which is one of the main anticancer drugs at present.. The principle is simple, but there are many difficulties in research and development: how do protein primers connect with "toxins" that attack cancer cells? How to ensure that you don’t play your medicine too early on the way to the "enemy camp"? How to "exit" in case of entering normal cells of human body? As a result, ADC drugs with complex structures have become research and development black holes. Once the research and development fails, it is difficult to find out which link has a moth.

　

How to design the parts of antibody conjugates

　

It is a big problem to maximize the drug effect ▼

　

　

In the past, this was the natural technical moat of large multinational pharmaceutical companies, which could greatly increase the price of drugs; But now, this is still the stage for China pharmaceutical companies to show their fists:At the end of 2023, BL-B01D1, an ADC dual-antibody drug for lung cancer and breast cancer, was developed by Bailey Tianheng, which set a record for China drugs to go to sea. Successfully went to sea with a down payment of $800 million and a potential price of $8.4 billion..

　

China’s biomedical industry has not only quickly caught up with the world-class phalanx, but also achieved a leading position in some fields.

　

Bai Li Tian Heng represents China Biomedical Haoheng.

　

(Photo: Bai Li Tian Heng) ▼

　

　

Both PD-1 and ADC use drugs to enhance the immune cell ability of human body or kill cancer cells. Then, directly enhancing the recognition ability of human immune cells can also achieve anti-cancer effect? It sounds like science fiction, but it has been realized in reality: using genetic engineering technology to inject receptor genes that can recognize the corresponding tumor cell antigens into immune T cells, so that they can accurately identify cancer cells. This is the CAR-T cell therapy technology.

　

Process diagram of CAR-T cell therapy technology

　

(Photo: MUSC)▼

　

　

At present, CAR-T is mainly used for the treatment of hematological cancers, including well-known leukemia. There are only ten models on the market in the world, and China has four models, including Regiosai injection of Wuxi PharmaTech, which is heavily held by biomedical ETF. In addition to the treatments already on the market,There are hundreds of CAR-T therapies being developed in China, the largest number in the world..

　

China’s bio-pharmaceutical industry, which once could only follow the big international pharmaceutical companies, has finally grown up.

　

Reggiorense injection is the second CAR-T product approved in China.

　

It is also the first CAR-T product of Class 1 biological products in China.

　

(Photo: Wuxi PharmaTech) ▼

　

　

The overall progress of this industry is inseparable from the joint efforts of this huge industrial chain. The listing of any drug requires sufficient clinical trial evidence and approval of relevant departments. For a long time, the approval speed of new drugs and new medical devices in China is slow, and a large number of drugs to be approved often pile up. In the high-speed development of drug research and development track, any time delay will miss business opportunities.

　

Since August 2015, the State Council issued the Opinions of the State Council on Reforming the Examination and Approval System of Medicines and Medical Devices, and a series of reform measures have been introduced one after another. In 2019, the newly revised Drug Administration Law established the MAH system for listed licensors, which mobilized the enthusiasm of more new drug research and development. The response of the market and industry is also extremely rapid, and various breakthroughs of biomedical enterprises in China have emerged in succession.

　

The core of MAH system is to separate drug marketing license from drug production license.

　

Allow pharmaceutical production enterprises, R&D institutions or researchers.

　

Become an independent drug marketing license holder

　

(Photo: Drug Administration Law) ▼

　

　

Go out to sea and look to the future.

　

The breakthrough in the related fields of innovative cancer drugs is only one aspect of the rapid progress of the biomedical industry in China. With the deepening of people’s cognition, medicine is more than just taking medicine to see a doctor; The future medicine will be a whole from genes to society. The biomedical industry in China is also making all-round progress.

　

Biomedicine in China is making efforts.

　

(Photo: Yitu. com) ▼

　

　

Since the 21st century, people have made many breakthroughs in cancer treatment. But no matter how to treat it, it is a process of suffering for patients. It would be best if it could be prevented.

　

At present, the human papillomavirus vaccine (HPV) is the only vaccine that has an obvious preventive and therapeutic effect on cancer (cervical cancer). Originally, it was expensive and all of it relied on imports. Many cities were in short supply and even went to Hong Kong to fight. nowDomestic bivalent HPV vaccine has been put on the market, and the cost of vaccination has been greatly reduced..

　

Bivalent HPV vaccine independently developed and produced by watson biological.

　

A needle costs less than 400 yuan.

　

(Photo: released by Kunming) ▼

　

　

People’s recognition of domestic vaccines is real.Zhifei Bio and watson biological held by Biomedical ETF.They all rely on relevant vaccine products to achieve good results in the capital market. It can be expected that this market will continue to grow after the domestic nine-valent vaccine is listed around 2025.

　

▼

　

　

　

Under the constant technical update,The pharmaceutical industry will continue to reshuffle and opportunities will continue to emerge..

　

An unprecedented wave of aging has arrived, and the biomedical industry with long-term sustainable development potential is undoubtedly the biggest outlet under this trend. Houston Medical City has proved to us that this industry has unlimited potential and long-term stability, and it is also a great opportunity for the city to realize industrial transformation. For individual investors, this is a win-win choice to support national health and obtain stable investment income; For practitioners, the market is changing with each passing day, and there are many opportunities but fierce competition.

　

To win the hard bones in the field of medicine, we need to unite from policy to market, as well as various therapies and all directions. Various fields with great prospects will gradually merge into one. It should be only a matter of time before China has its own world-class medical center.

　

Swipe up and down to view references:

　

Arnold, C., Webster, P. 11 clinical trials that will shape medicine in 2024. Nat Med (2023).

　

Chau, C.H., P.S. Steeg, and W.D. Figg, Antibody-drug conjugates for cancer. Lancet, 2019. 394(10200): p. 793-804.

　

Hao
MM, Stamp LA. The many means of conversation between the brain and the
gut. Nat Rev Gastroenterol Hepatol. 2022 Dec 14. doi:
10.1038/s41575-022-00725-4. Epub ahead of print. PMID: 36517617.

　

Hu
Y M , Guo M , Li C G ,et al.Immunogenicity noninferiority study of 2
doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine
In Girls vs.3 Doses in Young Women [J]. China Science: Life Sciences English Edition, 2020, 63(4):10.

　

Lu
Z, Chen Y, Liu D, et al. The landscape of cancer research and cancer
care in China. Nat Med. 2023; 29(12):3022-3032.
doi:10.1038/s41591-023-02655-3.

　

Majzner
R G , Mackall C L .Clinical lessons learned from the first leg of the
CAR T cell journey[J].Nature medicine, 2019,
25(9):1341-1355.DOI:10.1038/s41591-019-0564-6.

　

Schuhmacher
A, Hinder M, Dodel A, Gassmann O, Hartl D. Investigating the origins of
recent pharmaceutical innovation. Nat Rev Drug Discov. 2023
Oct; 22(10):781-782. doi: 10.1038/d41573-023-00102-z. PMID: 37407752.

　

Wiener CM, Wang Qing, Yin Kanhua. "From gene to society" —— Design logic and implementation process of the new curriculum system of Johns Hopkins University School of Medicine [J]. Fudan Education Forum, 2012 (3): 7. DOI: 10.3969/j.ISSN.1672-0059.2012.03.

　

Zheng
J , Xie Y , Ren L ,et al.GLP-1 improves the supportive ability of
astrocytes to neurons by promoting aerobic glycolysis in Alzheimer’s
disease[J].Molecular Metabolism,
2021:101180.DOI:10.1016/j.molmet.2021.101180.

　

Li Wenshuo. Medical Industry and Urban Renewal: the Transformation Road of Pittsburgh, an American Industrial City [J]. Qiushi Journal, 2017,44 (6): 7. doi: CNKI: Sun: qsxk.0.2017-06-022.

　

Li Zhenying. On the transformation strategy and policy of Pittsburgh, the American "Steel Capital" [J]. Journal of Quanzhou Teachers College, 2009 (03): 82-86. DOI: 10.3969/j.ISSN.1009-8224.2009.03.016.

　

Pan Wenzhuo, Cao Yongkang. Historical investigation of urban renewal in the United States-taking Pittsburgh as an example [J]. 2019.

　

Ye Xiaozhen, Shao Jiaqing. Progress in clinical application of smegliptide [J]. Chinese Journal of Diabetes, 2022,14 (Z1): 1-8. DOI: 10.3760/CMA.J.CN115791-20220721-00353.

　

Yin Junxiang,. High-tech Park Leading Regional Economic and Social Development —— Development Experience and Enlightenment of Texas Medical Center in the United States [J]. Outlook of Global Science and Technology Economy, 2015,(07).

　

National Health and Wellness Committee of People’s Republic of China (PRC), Guidelines for Diagnosis and Treatment of Diffuse Large B-cell Lymphoma (2022 Edition).

　

2023
BREAKTHROUGH OF THE YEAR. Retrieved December 14, 2023 from
https://www.science.org/content/article/breakthrough-of-the-year-2023

　

* The reference to individual stocks is for reference only and does not constitute investment advice.

　

* The content of this article is provided by the author and does not represent the position of the Earth Knowledge Bureau.

　

Cover: Yitu. com

　

END

　

　

　　In 2020, under the catalysis of the epidemic, star live broadcast with goods became one of the key words of this year’s industry.

　　Since April, there have been more and more stars with live broadcasts. According to incomplete statistics, more than 100 stars, including Liu Mintao, Amanda, Zheng Shuang, Chris Lee and Z.TAO, appeared in the live broadcast room or e-commerce parties on major platforms in the recently concluded 618 Shopping Festival. And stars including Wang Han, Tamia Liu and Michael Chen have opened their own live broadcast rooms, and started to do live broadcast with goods alone.

　　From the "re-employment of dead stars" to the arrival of many stars, live broadcast with goods has gradually become a new outlet in the industry. However, what is the effect of star with goods?

　　From a little low to a craze,

　　Live broadcast with goods into a star "sideline"

　　Before this year, there seems to be a natural and insurmountable gap between live broadcast and stars. Last June, Ada had a live broadcast with goods on a live broadcast platform. During the activity, she stood with online celebrity, the head of the platform, shouting and selling goods. This live broadcast with goods made Ada board the hot search, which was followed by the ridicule of netizens.

　　At that time, the stars who went to live broadcast with goods were closely connected with the word "out of breath", so most of the stars and star teams were resistant to live broadcast with goods, and fans would feel that it was a bit low for their idols to live broadcast with goods.

　　But what I never expected was that in the past year alone, star live broadcast with goods has become a trend, and some netizens even joked that "at present, the live broadcast platform has propped up half of the entertainment circle".

　　Beginning in April, CCTV News launched a special live broadcast of public welfare goods, and CCTV hosts and artists such as Zheng Shuang and Wong Cho Lam joined in one after another. "CCTV boys" also created a good result of more than 500 million turnover in three hours; In May, Tamia Liu launched a live broadcast with goods in Taobao as the "Chief Optimization Officer of Juhua Cost-effective", and the sales in three hours reached 148 million; In June, the hit variety Sister Braving the Wind and Waves cooperated with Tik Tok, and many "sisters" in the program will appear in the live broadcast room for a total of 12 live broadcasts with goods.

　　In just one year, everyone’s attitude towards live broadcast with goods has changed so much. What do the stars really like about live broadcast with goods before they are willing to put down their posture and enter the live broadcast with goods?

　　To some extent, the "incarnation" of the stars is the result of market demand. In the past two years, the film and television industry has been hit hard, especially the epidemic situation has made the film and television winter worse, the start of the crew has shrunk dramatically, and the job opportunities of the stars have collectively decreased. The offline content is blocked, and all walks of life have turned to "online". The live broadcast of goods above the tuyere can be said to be the hottest publicity exposure at the moment, opening up a new path for the stars who are "waiting for employment". According to the Beijing News, waist artists’ income from a brand live broadcast is generally six figures, which is higher than that from participating in a variety show recording, and they can also get corresponding publicity resources, which can be described as killing two birds with one stone.

　　At the same time, e-commerce and short video platforms have also shown an embrace attitude towards the live broadcast of stars with goods, and launched a series of support policies to vigorously attract star users. For example, Taobao Live launched the "Star Start Plan" and gradually increased the intensity of introducing stars; After Tik Tok invested the resources of the whole station to make the live broadcast with goods in Luo Yonghao the first shot, it attracted more stars to join the ranks.

　　From the occasional guest promotion to the opening of the live broadcast room, the star with its own traffic enters the game, and the platform is naturally happy. Last year, only some stars who had no burden took the lead in testing the water. For example, Li Xiang changed his Weibo name to "anchor Li Xiang" and threw himself into the live broadcast craze. For example, stars such as Wong Cho Lam and Aaron Kwok parachuted into online celebrity’s live broadcast room. This year, it has become a visible trend for stars to sink and live with goods.

　　Live delivery is actually a "technical activity"

　　The reason why the platform attaches importance to the live broadcast of stars with goods is that stars can bring traffic and attention to the platform and accelerate the destruction of the circle. This year, the epidemic has also brought a big impact to the e-commerce platform. According to the data, in the latest quarterly report, compared with the previous quarter, Alibaba’s revenue fell by 7.55%, JD.COM fell by 14.3%, and Pinduoduo plunged by 39.4%.

　　As a result, Taobao Live invited 300 stars to start the tide of star goods; Poly-cost-effective, together with Tamia Liu, Jing Tian, david lee and other stars, entered the live broadcast ecology with 10 billion subsidies; JD.COM Live took the "Beijing Consumer Season" as an opportunity to invite a number of well-known hosts to bring goods in the form of recommenders. For a time, e-commerce platforms have been laid out to seize star resources.

　　The addition of stars has indeed played a role in stimulating traffic and realizing sales transformation to a certain extent. In the following table, the first show record of live broadcast of stars with goods is sorted out, among which Zhang Ting, who has been working hard in the e-commerce industry for many years, won the first place, and stars such as Yuqi Zhang, Hua Shao, Wang Han and Tamia Liu also created the first show sales exceeding one trillion.

　　However, as can be seen from the table, there are only a few stars who can take the lead, and it is not easy for most stars to do live broadcast with goods. Even if these stars bring their own traffic, it may be more fans and people who eat melons than real consumers who gather in the live broadcast room. Therefore, compared with koL, the head of the live broadcast platform, the data of the stars’ goods is obviously dim. Even though the stars tried their best to imitate the various words of the head anchor and threw away their baggage and shouted "Buy in buy buy" in the live broadcast room, many stars were labeled as unsuitable.

　　Lin Yun started his first show with goods in Taobao live broadcast room, "Jelly Lin premiere, allow you good things". According to the data of melon, 888,700 people watched UV in a single live broadcast, with 26,000 pieces of goods sold, and the peak number of online users was only 17,100. Li XiaoLu’s debut with goods also frequently overturned. When introducing products, I almost read them according to the manuscript, and I also misspoke the price of the products. I am not familiar with the goods I brought, so I can only rely on the anchor friends to help me.

　　Therefore, at present, most e-commerce platforms still adopt the relatively safe operation mode of "star+anchor", which combines the specialty of the anchor with the traffic topic of the star. However, for some stars, they are unfamiliar with products and lack of professionalism, which makes them a "tool person" who politely cooperates with the anchor. It is inevitable that they are somewhat embarrassed.

　　Is it a long-term good business to bring goods live by stars?

　　At present, most stars participate in live broadcast with goods, or cooperate with the anchor in the form of "airborne" live broadcast or holding activities, not as a profession as the anchor, and the star live broadcast with goods is still in the exploration stage. Moreover, although the live broadcast of the stars brings high exposure to themselves to a certain extent, at the same time, a series of problems such as live broadcast rollover and follow-up product quality caused by unfamiliar business are also likely to cause a crisis of public trust in the stars.

　　On the one hand, the stars increase their exposure through the current hot e-commerce live broadcast, narrow the distance with fans, and establish an affinity for people, thus further circling the powder. In the previous live broadcast of Li Jiaqi and Yang Mi, Li Jiaqi was accused by netizens for her improper speech, while Yang Mi’s response to high emotional intelligence in the live broadcast made many netizens’ impression of her change; When Jin Jing, a comedian, visited the live studio in Li Jiaqi, she not only explained the products skillfully, but also made funny jokes one after another. Many netizens joked that "even Li Jiaqi will lose his job".

　　On the other hand, the live broadcast of stars with goods is also very likely to cause controversy, which will have an impact on their own performing arts. Frequent exposure consumes its own influence. If the stars frequently bring goods live, the audience will gradually get used to the appearance of them shouting "buy it, buy it" in the live broadcast room. When they return to their own performing arts career, the audience may find it difficult to get into the show for a while. The rollover phenomenon in live broadcast, such as high price, quality problems and after-sales situation, not only affects product sales and loses more and more consumers, but also may affect the audience’s evaluation of their personal image and works.

　　In addition, regardless of the ability to carry goods, the live broadcast itself has certain risks. Once the car rolls over, it will bring negative effects to itself, and even ruin one’s acting career. Zhai Tianlin, who doesn’t know HowNet, and Tong Zhuo, who changed his identity from "previous student" to "new student" by some means, are the best examples.

　　In the market environment where the film and television industry has not yet recovered, there may be more stars moving towards the road of live broadcast with goods. However, with more and more stars entering the market, consumers will tend to be rational sooner or later, and the bonus brought by the star aura will gradually decrease. At that time, the threshold of "live broadcast with goods" will be raised accordingly. Without the title of "star", I am afraid it is difficult to win the "killing" in the live broadcast of rivers and lakes.

　　— THE END —

　　Author | Li Yang

　　Editor | Yang Ni

　　Recently, Minhou County, Fuzhou City, Fujian Province, has effectively eased the cash flow pressure of automobile enterprises and added impetus to the development of automobile industry by implementing tax reduction and fee reduction policies such as value-added tax deduction and tax refund. The picture shows workers of an automobile enterprise in Minhou County assembling vehicles in the assembly workshop. Photo by Wang Wangwang (People’s Vision)

　　Activate the used car market, support the consumption of new energy vehicles and improve the parallel import policy of automobiles & HELIP; … A few days ago, the the State Council executive meeting focused on promoting automobile consumption, and deployed a series of policy measures from various aspects. The policy implementation predicted that the automobile and related consumption would increase by about 200 billion yuan this year.

　　Accelerated circulation of used cars

　　The meeting proposed to enliven the used car market and promote the renewal of automobile consumption. For small non-operating used cars, the restrictions on moving in cars that meet the national five emission standards will be completely lifted from August 1. From October 1, automobile sales enterprises will implement separate endorsement management and issue temporary license plates when applying for transfer registration.

　　In recent years, China has issued a series of policies to support the circulation of used cars, including abolishing the restrictions on the movement of used cars, reducing the value-added tax of used car distribution enterprises, and making the registration of used car transactions universal across provinces. Although the circulation environment of used cars in China has obviously improved, compared with mature automobile market countries such as Europe, America and Japan, its development is still immature. Cui Dongshu, secretary-general of the Passenger Car Market Information Association, told this reporter: "China’s used car industry has not got rid of ‘ Small, scattered and weak ’ The situation, the restrictions on the movement of used cars, the constraints of taxation methods and the lack of temporary property rights registration were important reasons that hindered the convenient circulation of used cars. "

　　In May this year, the State Council issued "A Package of Policies and Measures to Stabilize the Economy", proposing to completely cancel the policy of restricting the movement of second-hand cars, lift the restrictions on the movement of small non-operating second-hand cars that meet the national five emission standards nationwide, and improve the regulations on the registration, filing and vehicle transaction registration of the main body of the second-hand car market.

　　The Standing Committee of the National People’s Congress clearly proposed to accelerate the activation of the used car market, and gave a clear implementation date for the comprehensive cancellation of the restrictions on the movement of used cars and other related measures. "The complete cancellation of the restrictions on the movement of used cars will greatly promote the flow of used cars, further enrich the sources of used car markets and promote the formation of a unified national market for used car transactions. Especially for car dealers, this is undoubtedly a ‘ Gift package ’ 。” Cui Dongshu said.

　　According to the China Automotive Strategy and Policy Research Center of China Automotive Technology and Research Center, it is predicted that about 4.9 million old cars in China need to be updated this year. According to the average selling price of new cars of 150,000 yuan, the updating of these old cars is expected to bring 735 billion yuan of consumption-driven effect this year.

　　Support the consumption of new energy vehicles

　　The meeting made it clear that it is necessary to support the consumption of new energy vehicles. Vehicle purchase tax should be mainly used for highway construction, etc., considering the current practical research on the extension of the policy of exempting new energy vehicle purchase tax after the end of the year. Break the local protection of the new energy vehicle market.

　　"The cumulative sales volume of new energy vehicles has risen sharply from 20,000 at the end of 2012 to 11.08 million at the end of May this year. Since 2015, production and sales have ranked first in the world for seven consecutive years." Xin Guobin, Vice Minister of the Ministry of Industry and Information Technology, said recently that China’s new energy automobile industry has become an important force leading the transformation and upgrading of the global automobile industry.

　　China has been exempted from vehicle purchase tax for new energy vehicles since September 1st, 2014. After the implementation of the policy, the purchase cost of new energy vehicles has been effectively reduced and the consumption of new energy vehicles has been directly promoted. According to the current policy, the tax exemption policy will expire on December 31, 2022.

　　China Automotive Strategy and Policy Research Center of China Automotive Technology and Research Center pointed out that this regular meeting of the National People’s Congress clearly proposed to consider the extension of the current practical study on the exemption of new energy vehicle purchase tax policy, which will promote the relevant departments to speed up the research, comprehensively consider key factors such as tax revenue and industrial development, and put forward practical policy plans to better play the guiding role of policies in the industry.

　　Cui Dongshu suggested that the policy of exempting new energy vehicles from vehicle purchase tax should continue until 2023, and study the implementation method of gradually resuming the collection of vehicle purchase tax, so as to turn the collection of vehicle purchase tax into a tool to stimulate the consumption of new energy vehicles, ensure a smooth transition and continuously improve the penetration rate of new energy vehicles.

　　Consumers will have more choices.

　　The meeting stressed that it is necessary to improve the parallel import policy of automobiles, develop automobile financing leasing in an orderly manner, and support the construction of parking lots.

　　Cui Dongshu introduced that for consumers, parallel imported cars simplify the circulation and allow consumers to buy imported cars at more affordable prices; The policy of parallel import of automobiles has realized the simultaneous listing of foreign products in China market, enriched the models of automobiles and won the favor of consumers.

　　Since the pilot of parallel import of automobiles was deployed in the State Council in 2014, the scope of the pilot of parallel import of automobiles has been gradually expanded, the import volume has been increasing, and the imported models have become increasingly rich, which has played an important role in breaking the monopoly of imported automobiles, accelerating the innovation and development of automobile circulation system, stimulating the vitality of automobile market, and meeting the diversified needs of consumers. Up to now, 22 of the 29 vehicle import ports in China are carrying out parallel automobile import business.

　　Cui Dongshu said: "The clear improvement of the parallel import policy this time will help to solve the key problems in the development of parallel import of automobiles as soon as possible, and also help to comprehensively expand the pilot effect. It is even better news for consumers, which will help restore consumer confidence and stimulate consumer demand. "

The writer of this article is the writer @ 中中中中中中中中.

I am greedy and lazy, I don’t like labor, I just love movies.

In the last two weeks, many people around me have been watching an Amway domestic drama, The Beginning.

300+ Weibo hot searches, 200,000 people’s passionate scores, and 8.2 douban scores are all in full swing to discuss the plot trend.

It was the first drama of the year.

The Beginning is adapted from the novel of the same name by Prayer Jun and tells a story about the cycle of time.

After a bus exploded, Li Shiqing (Angel) found herself in a time cycle, going back to the minutes before the explosion.

After she pulled her neighbor Xiao Heyun (Bai Jingting) into the cycle, the two of them started time adventures again and again.

They want to save their own lives and the lives of the whole car, and they want to find out who set off the bomb in the car.

There are 15 episodes in the series, so far 13 episodes have been broadcast, and the protagonists have gone through 24 cycles.

The murderer is already in the light, and the rest is to see how the protagonist can minimize the damage and solve the bomb crisis. I believe how many people can’t wait to see the finale.

The opening year of "The Beginnings" is very surprising. It presents a concept of "infinite flow" which is not new now to the audience with new actors and new topics.

On the home page of the original novel "Beginnings", three keyword tags were posted, namely: infinite flow, Puzzle-solving Style and Confined Space.

Infinite flow, which is very close to the concept of time cycle, is a type of classification, which is common in bamboo slips and foreign dramas.

Baidu Encyclopedia’s definition of infinite flow is more general-

"All-encompassing, including infinite elements, including science, religion, mythology, history, reality, movies, animation, etc., and above them, there is a reasonable world outlook that includes all these."

But to be more precise, infinite flow refers to the samsara who keeps breaking through in the replica world, and completing the task is the way to settle down.

In this way, The Beginning can only be regarded as a branch of infinite flow: Time Loop.

Li Shiqing and Xiao Heyun don’t have much autonomy, but they are constantly pushed back to the time node when the bomb got on the bus by force majeure, and they read the files again and again.

There are not many choices in front of them, only getting off or not getting off: getting off means stealing half a day’s leisure and recycling tomorrow; Not getting off the bus means two choices: stop the explosion and still explode.

They tried one by one in several cycles, and it was difficult to find a satisfactory solution.

Although there are not many works of Time Loop series in China, if we look around the world, we will find that it has long been a mature drama mode.

Groundhog Day, a comedy, tells the story of a bored weatherman trapped in a groundhog celebration day, reminding us to live in the present with his great insight.

The horror category includes "Happy Death Day". The beautiful woman died on her birthday. She is constantly resurrecting to find the real murderer who killed herself in an attempt to jump out of the time cycle.

The suspense category includes Source Code. The pilot wakes up repeatedly on the train to look for hidden bombs, only for 8 minutes at a time, and all this is his brain performing the task of brainwave source code.

At the beginning of the broadcast of "Beginning", it also caused a small-scale questioning storm because of its frequent collision with "Source Code".

We can understand why different audiences have different views on The Beginning, which depends on everyone’s aesthetic psychological threshold.

If you have seen many Time Loop works on weekdays, you will feel that "Beginning" is playing in old terrier; If you are a younger generation audience who have little contact with this type before, you will taste many innovations in the beginning.

After all, in the popular domestic drama category, The Beginning is quite innovative and sincere.

Let’s look at the other two labels of the beginning: puzzle wind+confined space. When these two elements collide with each other, we can easily think of the reasoning works of the storm villa model.

However, chasing the murderer by reasoning is not the focus of the beginning at all.

Li Shiqing and Xiao Heyun, the protagonists, have not been portrayed as omnipotent salvation heroes, and their reasoning ability is not very good. Finding the murderer depends on trial and error again and again.

In the end, they finally found out who the murderer was. At this moment, more than half of the passengers in the car have been tried by them.

Xiaowan believes that the fire of Beginnings lies not in its imitation of mature models, nor in the deliberately inserted suspense detection line, but in the presentation of local social reality problems.

In other words, it doesn’t follow the science fiction school or the reasoning school, but the social sentiment school.

In 5~8 episodes, Li Shiqing and Xiao Heyun began to investigate the suspects on the bus. The drama opens God’s perspective and fills the background of passengers. Almost everyone has a story.

Liu Dan’s "malicious role" successfully came out of the circle.

Lu Di, an anime fan who is immersed in the second world, is the only person in the whole car who unconditionally believes in recycling theory. He is gearing up to circulate with the protagonist, thus becoming the savior in the animation he has seen.

He also promised that in case he didn’t enter the cycle, the protagonist could call him by calling out his nickname. At the critical moment of episode 10, Xiao Heyun successfully used his nickname to harvest an effective labor force.

This line symbolizes sincere idealism. Lu Di is not only like a middle school patient who didn’t grow up, but also has all the characteristics of a passionate protagonist. He reflects the innocence that the adult world can’t tolerate.

Passengers Ma Guoqiang and Lao Jiao both appeared as suspicious villains. Ma Guoqiang hit and run many years ago, carrying his life on his back and serving several years in prison.

But on the other hand, his elderly father went to the city to look for his son, and brought a whole bag of the sweetest watermelon in his hometown to his son who didn’t want to meet him.

Laojiao is the most common migrant worker in the city, living in someone else’s garage, just to send home the reward for doing odd jobs for her daughter to study. Lao Jiao’s suitcase is even stuffed with bulk sanitary napkins for her daughter.

The killers are not terrorists who have been flattened, and the secrets behind them are scary and bleak. Many times, the perpetrator’s last identity is the victim.

"Beginning" continues to outline the story behind the supporting roles until their images become more and more warm, so that every audience can easily associate with an acquaintance or passer-by in their lives.

The Noon Sunshine Company, which produced "The Beginning", happens to be very good at writing stories of sadness and joy at the bottom. For example, last year’s "Children of the Qiao Family" described the family story struggling on the edge of the city with great efforts.

In The Beginning, Noon Sunshine Company did the same thing, touching people’s hearts with the gripping stories of bus passengers, mobilizing the audience’s senses and memories, thus achieving emotional resonance.

While profiling the joys and sorrows of small people, it also faintly reflects the shadow of social news: the murderer who was violently attacked by the internet actually has another origin; Grab the driver’s steering wheel and be resisted by the whole car; Three-no sanitary napkins in bulk are the difficulties of many poor women …

Creators gradually build up the blood and flesh of society in accordance with the tendons and bones of realism.

Time Loop is just a loose condom, which can’t stand scrutiny. It can’t explain the mystery of parallel universe and standby time, but the beginning is not here, and the drama tries to expose some heavier facts and life.

"Beginning" held high the high concept setting, and gently placed it in various social situations. This is out of self-consideration, and it can also be regarded as a cautious attempt in the safe area.

However, The Beginning not only made a good start for the domestic drama market in the New Year, but also set a good example for the film and television of infinite flow’s novels.

Over time, maybe we can see better and bolder domestic dramas of the same type.

Note: Some pictures in this article are from Douban and the Internet. If there is any infringement, please contact us actively.

On March 13th, 2024, the opening ceremony of 2024 Hui ‘ai Carnival and the first Hui ‘ai Exhibition of "Empowering the Future with Science and Technology" hosted by Beijing Disabled Persons’ Federation and hosted by Beijing Disabled Persons’ Service Demonstration Center opened in Hui ‘ai Building, Beijing Disabled Persons’ Service Demonstration Center. The exhibition shows the products and services of science and technology for disabled people with different disabilities, so that the majority of disabled friends can truly feel the convenience brought by the achievements of science and technology for their lives and work through the visit experience of this science and technology exhibition.

　

　　Source: WeChat WeChat official account "China Youth Publishing House" (ID: CYPG 1963), Author: Chen Zhangle (Editor-in-Chief of China Youth Publishing House)

　　People need a little spirit, and a country and a nation need a little spirit. The power from the spirit is the most surging, lasting, noble and great.

　　For more than 5,000 years, the Chinese nation has created a long and splendid Chinese civilization with great creative spirit, great struggle spirit, great unity spirit and great dream spirit.

　　Since the birth of the Communist Party of China (CPC), under the leadership of the Party, under the guidance of Marxism, under the guidance of the lofty ideal of communism and the dream of the great rejuvenation of the Chinese nation, generate, a son of the Chinese nation, has made great strides and written a series of brilliant movements with a sense of earth-shaking, earth-shaking and earth-changing in the grand process of revolution, construction and reform in China.

　　The power of spirit needs to be inspired, recorded, spread, inherited and promoted by spiritual products.

　　Classic series of "Three Reds and One Creation" (Red Rock, Red Sun, Red Flag Spectrum and Entrepreneurship History) by China Youth Publishing House.

　　"Three Reds and One Creation" in the History of Publishing and Youth Spirit in New China — — Classic books such as Red Rock, Red Sun, Red Flag Spectrum and Entrepreneurship History have created a group of heroes such as Jiang Jie, Xu Yunfeng, Shen Zhenxin, Zhu Laozhong and Liang Shengbao, who, under the leadership of the Communist Party of China, are constantly pursuing, struggling, selfless dedication and fearless sacrifice for national independence, people’s liberation, national prosperity and people’s happiness.

　　According to the novel Red Rock, the film Eternal Life in Fire shows Xu Yunfeng (Zhao Dan) and Jiang Jie (Yu Lan).

　　这些主人公是无数革命先烈、英雄人物、党和人民好儿女的化身；他们的故事是一代又一代中国共产党人和中国人民追梦筑梦故事的缩影；他们身上体现的强大精神力量，感染、感召、鼓舞、激励着一代又一代中国青年投身党和人民伟业，在为实现站起来、富起来、强起来而努力拼搏中创造无悔的青春。

　　今年初以来，面对新冠肺炎的突然来袭，广大青年响应党和人民召唤，毅然站出来，勇敢冲在第一线。在援助武汉、湖北的医护人员队伍中，在突击建设雷神山、火神山和方舱医院的队伍中，在奔波于各个岗位的志愿者队伍中，在驻守社区村镇防护检疫的基层干部群众队伍中，在穿梭于各个街道小区、守护经济社会生活正常运行的快递小哥队伍中……到处都可以看到“90”后甚至“00”后在奋战奉献的身影。

　　习近平总书记在给北京大学援鄂医疗队全体“90后”党员的回信中，赞扬“在新冠肺炎疫情防控斗争中，你们青年人同在一线英勇奋战的广大疫情防控人员一道，不畏艰险、冲锋在前、舍生忘死，彰显了青春的蓬勃力量，交出了合格答卷”，指出“广大青年用行动证明，新时代的中国青年是好样的，是堪当大任的！”

　　The approval of the general secretary makes the vast number of young people feel extremely proud, and it is also the endless driving force for youth struggle!

　　What is the future of the country like the youth.

　　Youth has spiritual strength, and the country has a future.

　　We are proud to see that in today’s younger generation, the classic power of "three reds and one innovation" is being passed on, the national spirit is shining, the ideals and beliefs are shining, and the excellent quality is shining!

　　On this special year’s World Book Day, let us reread the classic of "Three Reds and One Creation" once again, so that our hearts can gain a full energy and let us hold high the ideal sail of youth and forge ahead in the new era!

　　1. Pay attention to the WeChat WeChat official account of "Central Committee of the Communist Youth League" and "China Youth Publishing House". Welcome to leave a comment at the end of the article, and write down your story with the books in the "Three Reds and One Creation" series, your thoughts on youth responsibility, etc. According to the comprehensive ranking of the quality of comments and the number of likes, the top 20 readers on each platform will get a book related to comments (activity time: April 23, 2020 — May 5, 2020).

　　2. Pay attention to the headline numbers of "Central Committee of the Communist Youth League", "China Youth Publishing (Head Office)" Weibo and "Central Committee of the Communist Youth League" today, and forward the relevant content lottery.

　　Let’s act quickly! (The list of books will be published on China Youth Publishing House WeChat WeChat official account on May 6, 2020. )

　　CCTV News:Mobile phone application software, also known as App, with the rapid development of mobile Internet, the functions and classifications of App are more diverse. In November last year, CCTV news channel exposed the chaos of pornographic content in the "learning App for primary and secondary school students". Recently, parents in Chongqing, Guangdong, Beijing and other places have reported that the chaos of learning apps has come back, and the homework apps recommended by many schools have become hiding places for online games.

　　Recently, Mr. Zhao from Shenzhen told reporters that his son, who is in the third grade of elementary school, uses a mobile phone App called "A Primary School Student" every day because the teacher has to arrange homework on it. Recently, he found that the child continued to hold the mobile phone after completing the homework in the App. When he looked carefully, he found that the interface of online games Appeared in this app.

　　Mr. Zhao provided the reporter with a screenshot of the page of this App. Apart from the tips of "whether the teacher arranges homework", there are also sections such as "Growing World", "Parents’ Reward" and "Tasks". But Mr. Zhao reflected that online games appeared in the section of "Growing World", and children can get certain scores by completing tasks, and the scores can be exchanged for virtual currency, so as to buy props or raise electronic pets to play PK with their classmates. Not only that, users can also choose to pay directly in the "mall" to buy game props. Mr. Zhao is worried that the children are addicted to the games in this App, but in the face of the teacher’s request, he has to agree that the children will continue to use it.

　　Coincidentally, Mr. Xiong from Beijing also told reporters that this "One Primary School Student" homework App was installed under the recommendation of the school teacher. The teacher can arrange homework on it and then send the students’ completion to WeChat group, as long as parents do not follow the requirements, they will be urged. Mr. Xiong said that there are so many settings of "game form" in this App that it is easy to cause children’s buying impulse. In less than two months, he has made 13 purchases at the request of his children and spent more than 1,200 yuan.

　　In the survey, CCTV reporters also found that some operators who study App, in addition to using the guise of teaching to promote games, have a more "slick" approach, which is to transfer the game channel in App to WeChat WeChat official account, and guide primary and secondary school users to places outside the App in an attempt to escape supervision.

　　In September this year, some parents reported that there were a lot of content unrelated to learning in an App called "Interactive Homework". The reporter saw in this App that in one-third of the interface, the scrolling words of "DIY by hand", "Meitu area" and "Twelve constellations" are very eye-catching, and clicking on the "recess" section in the interface will enter the column area of these scrolling words. One of the columns called "Little Mutual Talk" is marked with the following words — — "Words, music and movies hope to become a spiritual place in the hearts of students".

　　After parents reported that these contents would affect students’ learning, "interactive homework" closed the "small talk" section. However, the reporter found that this App has started an article on content rectification. "Interactive Homework" opened the WeChat WeChat official account at the same time as the App, and named it "Homework Little Mutual". On October 13th, the reporter entered this WeChat WeChat official account and found that in addition to the "answer query" column in the "Interactive Homework" App, the "latest game" column was placed in the middle position. Click on it and there will be games such as "circle of friends" and "the richest man", and the "game hall" contains nearly 100 online games.

　

　　The reporter found that in the interface before entering each game, it was written in bold font, "Don’t play the game after finishing your homework?" Do you want to be a nerd! " . In the game called "circle of friends", users get points by throwing dice, and when the points reach a certain number, the game sets up a link of "visiting friends", and a female avatar user marked "online" is recommended by the system to click and visit. At the same time, the game also set up a "world chat" section. The reporter clicked into it and found a lot of information about making friends, some of whom used pictures of scantily clad clothes as avatars.

　　WeChat WeChat official account, an "interactive homework", not only uses games to guide primary and secondary school students to socialize, but also contains a lot of online games with sexual suggestion, sexual temptation and bad value orientation. The reporter saw in a game named "Dafuhao" on the WeChat official account page that users must first choose a role, and after choosing to be the protagonist, the game will actively push a photo link of "Secretary’s Resume", which includes personality characteristics and measurements of women.

　　In the "Game Hall" column of WeChat official account, the reporter found that nearly 100 games can be logged in without real-name registration, and most of them have consumer channels such as "Prop Mall". The reporter randomly clicked on a game called "Jiangshan Beauty". The introduction of this game reads: "This is a palace fighting mobile game developed by original simulation management, and all kinds of beautiful women are waiting for you here." Users only need to authorize QQ number to log in. In the brief introduction of a game called "Emperor Lucky 2", it is even written that "you can experience taking a wife and concubinage, monopolizing power and enjoying the beauty of the world" in the game. After clicking on it, the reporter found that there are a lot of voices and words of sexual temptation in the game.

　　Legal experts pointed out that learning apps use the registered primary and secondary school students’ user resources and transfer them to other platforms, and the practice of profiting from them through a large number of online games has violated the legal and moral bottom line.

Live broadcast: On June 23rd, FIFA announced the latest ranking of the national men’s soccer team in the world, with Brazil ranked first, Belgium and Argentina ranked second and third. Italy ranked seventh, France, England, Spain, the Netherlands, Portugal and other powerful countries all entered the top ten, while Germany ranked eleventh.

FIFA’s latest men’s soccer rankings

1. Brazil

2. Belgium

3. Argentina

4. France

5. England

6. Spain

7. Italy

8. Netherlands

9. Portugal

10. Denmark

11. Germany

12. Mexico

13. Uruguay

14. America

15. Croatia

16. Switzerland

17. Colombia

18. Senegal

19. Wales

20. Sweden

(CC fried meatballs)

　　Editor’s note:Water is the source of life and is vital to human health. Drinking water can promote the body’s metabolism and absorption of nutrients, but drinking it wrong may be harmful to health. Therefore, how to drink water is very particular. Let’s take a look.

　　The misunderstanding of drinking water is constant

　　Last summer, the northern hemisphere continued to suffer from high temperature, and the number of patients with "water poisoning" in hospitals in many regions of Europe doubled. According to the Danish Local Times, some Danes drank a lot of tap water to cool off the heat, which caused them to get sick. Take Hawkbell Hospital as an example, the number of patients with "water poisoning" this summer is 10 times that of previous years. According to local doctors, drinking too much water will increase the water content of blood and reduce the sodium content, which will lead to the imbalance between salt and water. Severe imbalance may cause "hyponatremia", and patients may have brain swelling, headache and other phenomena, and even lead to epilepsy, shock and death.

　　Zhao Feihong, director of the Health Drinking Water Professional Committee of Beijing Health Protection Association, said that when people sweat a lot, in addition to water loss, many electrolytes mainly sodium salts will also be discharged with sweat, and people often drink a lot of water to replenish water. This is a misunderstanding. Drinking pure water alone can’t replenish the missing electrolyte, and even further dilute the electrolyte concentration, which leads to the imbalance of the ratio of water and electrolyte in human body and triggers the body to produce different degrees of stress response. "However, in general, drinking more water will not cause serious problems ‘ Poisoning ’ Only people with poor kidney and cardiopulmonary function need special attention. "

　　Zhao Feihong said that there are still many misunderstandings about people drinking water. First, drinking water too fast and replenishing a large amount of liquid in a short time will increase the burden on organs such as the heart and kidneys, which may easily lead to headache, edema and elevated blood pressure. Second, drinking water is too "ice". When the body temperature is high, it is best not to drink drinks below 5℃. Drinking cold water will stimulate the stomach and lead to stomach cramps and diarrhea.

　　Water accounts for 60%~70% of human body weight, and plays an important role in forming whole body tissues, regulating body temperature, promoting metabolism of various systems of the body, and assisting absorption, transportation and excretion of various substances. Batman, an American doctor of medicine, recorded many studies in the book "Water is the Best Medicine", which proved that healthy drinking water can relieve hypertension, diabetes, allergies, asthma, cancer and other diseases. He once cured more than 3,000 patients with water.

　　How to drink water correctly

　　When you feel thirsty, the water loss of adults is about 2% of your body weight, and that of children is about 2%~5%. At this time, your body functions begin to be affected. Lack of water can also lead to loss of appetite, depression, dry skin, hoarseness and general weakness, which can be life-threatening in severe cases. Zhao Feihong suggested that you should develop the habit of taking the initiative to drink water, and don’t wait until you are thirsty. Drinking water should follow the principle of "small amount and multiple times": 100~150 ml is suitable for each time, and the interval is about half an hour; Drinking water with a small mouth is more thirst-quenching than pouring water with a large mouth, which is beneficial to human absorption.

　　There are four best times to drink water. After getting up in the morning, around 10 am, 3-4 pm and before going to bed at night, it is currently recognized as the four "best drinking periods" in a day.

　　Zhao Feihong explained that people do not drop water during sleep, and the formation of nocturia and the loss of water through breathing and skin make the body in a physiological state of water shortage, which leads to the increase of blood viscosity and the accumulation of metabolites in the body. Therefore, drinking a glass of water half an hour before going to bed can alleviate the above phenomenon and reduce the risk of cerebral thrombosis. Drinking a glass of water after getting up in the morning takes only 20 seconds, and water can enter the blood, which makes the blood dilute rapidly and improves the water shortage at night.

　　At least 1.5 liters per day. According to Dietary Guidelines for China Residents (2016), the recommended daily drinking water for adults is 1.5~1.7 liters. Gu Chuanling, deputy secretary-general of the Capital Health Food Nutrition Society, said that people’s daily drinking water can be appropriately increased according to the following factors:

　　1. Living environment. In hot weather, people sweat more and lose water faster, so it is necessary to increase water supply. It is easy to dry in autumn and winter, and in the heating room in northern winter, the water evaporates quickly, so it is necessary to increase the amount of drinking water.

　　2. Dietary factors. The diet is salty, and when the human body discharges excess salt, it needs to consume more water; If you eat food containing more protein, your blood osmotic pressure will increase slightly, and you need extra water to excrete the urea produced by protein. At these times, you need to pay attention to drinking more water.

　　3. Physical condition. When a cold has a fever, the human body will lose a lot of water in the form of sweating, so it is necessary to increase the amount of water.

　　Boiled water is best.

　　China Nutrition Society recommended that boiled water is the most suitable drinking water for human body. American scientists have found that when the boiled tap water is cooled to 25~30℃, the chlorine content is the lowest, and the biological activity of the water is also increased. It can easily penetrate the cell membrane, which can promote the body’s metabolism, enhance immune function and improve the body’s disease resistance.

　　Sweet drinks, functional drinks, fruit juice, strong tea and coffee can’t completely replace drinking water. Zhao Feihong said that all kinds of sweet drinks and fruit juices are high-sugar and high-calorie drinks. The human body needs to consume more water to complete metabolism and cannot replenish water well. Functional drinks, strong tea and coffee all contain caffeine, which has diuretic effect in itself and is not conducive to human hydration.

　　Special people pay attention to drinking water

　　Children. Dietary Guidelines for China Residents, Balanced Dietary Pagoda for Preschool Children in China and Dietary Guidelines for School-age Children in China suggest that the water demand for children under 10 years old varies with age: 6 months to 1 year old, and the total daily water intake is 900 ml (milk/food+drinking water); 1~2 years old, the total water intake is 1300 ml (milk/food+drinking water); 2~3 years old, drinking 600~700 ml; 4~5 years old, 700~800 ml; 5~7 years old, 800 ml; 7~10 years old, 1000 ml. Gu Chuanling reminded that children’s initiative to drink water in time is generally poor, and they like to drink sweet drinks. Parents should do a good job of monitoring and remind their children to drink water in time.

　　Lactating women. About 90% of milk is water, and milk secretion is closely related to the daily intake of water. Drinking more water under the condition of ensuring balanced nutrition is beneficial to milk secretion. Gu Chuanling said that they are generally recommended to drink more water than ordinary women, about 2.1 liters per day.

　　Old man. Old people tend to urinate frequently, and if they don’t drink water regularly, they are prone to thick blood and high blood fat, which will eventually cause a series of metabolic diseases. Therefore, the elderly should drink water frequently, and the amount of drinking water should be increased accordingly, which can be judged according to the color of urine: if the urine is light yellow, 250 ml of water should be replenished in time; If it is brown, it means that the body is seriously short of water, and you should drink 500 ml of water.

　　Office workers. Office workers can replenish 200 ml of water in time after arriving at the company every day, which is conducive to promoting brain activity and working concentration. In addition, office workers who sit indoors for a long time are prone to get fat. Drinking 200 ml of water half an hour before meals is conducive to increasing satiety and reducing food intake to some extent.

　　Manual workers. Athletes and outdoor workers need to replenish water in time after a lot of physical activities. Zhao Feihong suggested that these people can properly replenish water about half an hour before physical activity. During the activity, they can replenish water with a small amount of water. After the activity, they are not in a hurry to replenish water. After a while, they can replenish water and drink some light salt water appropriately.

　　Poor spleen and stomach, drink less water.

　　It is recorded in the medical book "Four Sages Heart Source" in Qing Dynasty: "Shui Gu enters the stomach, the spleen and yang are grinded, and the dregs are passed down, but for feces drowning, the essence is served, and it becomes qi and blood." If the spleen yang is insufficient (spleen yang is the function of spleen and stomach), the digestion and absorption of water is weak and it cannot be turned into qi and blood. People with poor spleen and stomach, such as loss of appetite, nausea and vomiting, frequent hiccups, abdominal distension and diarrhea, epigastric discomfort and other symptoms, had better drink less water in the morning to avoid further affecting the function of spleen and stomach.

　　Be careful when drinking water because of lung dysfunction.

　　Traditional Chinese medicine believes that besides breathing, another important function of the lung is "attending festival", including "dredging water channels". "Waterway" refers to the way that water and liquid move, that is to say, the lung can regulate the metabolism of water and liquid, mainly through the spreading and descending of the lung, and transport body fluid to all parts of the body by using lung qi, which can also promote the water and liquid to be lost to the bladder, so as to keep urine flowing smoothly. If lung function is impaired, such as frequent chest tightness, shortness of breath, wheezing and palpitation, cough with excessive phlegm, nasal congestion and runny nose, etc., water metabolism will also be poor, and drinking water indiscriminately will aggravate symptoms.

　　Traditional Chinese medicine believes that the kidney controls water and the bladder controls the gasification of water. Kidney plays a key role in regulating and maintaining water-liquid balance in the body. If there is a problem with kidney function, pay more attention to drinking water, otherwise there will be edema and unfavorable urination. When there is no need for drinking water, don’t force yourself to drink water, but keep your body in a state of peace of qi and blood.

　　Drinking too much water increases the burden.

　　Many chronic patients have thick blood and hope to dilute it by drinking more water. In fact, water can’t enter blood vessels immediately. Traditional Chinese medicine believes that the human body is a circular whole, and the metabolism of water should be completed under the coordination of various organs and tissues. If there are problems in the gasification of triple energizer, the transfer of viscera and the operation of qi and blood, water will not achieve the purpose of diluting blood, but will increase the burden on the heart, lungs, spleen and kidney. Dietary Guidelines for China Residents (2016) suggests that the daily drinking water should be kept at 1500~1700 ml.

　　Huang Yuanyu, a famous doctor in the Qing Dynasty, said: "If qi does not turn into water, it will stagnate on the upper side and become phlegm; if water does not turn into qi, it will stop accumulating on the lower side and become drinking. Generally speaking, yang deficiency leads to soil failure, and the golden water is swollen, all of which have the disease of retention of phlegm and retention of drink. Covering the phlegm and drinking, corruption and stagnation hinder the road of qi and blood around the week, and the spirit of the spirit is close to the aid. All diseases start and the changes are constant. " It means that if there is no yang, such as yang deficiency and spleen deficiency, and lung and kidney are not transported, water will stagnate into phlegm and form phlegm-drinking disease. Phlegm can block the circulation of qi and blood, leading to many diseases. People who often drink too much water have a heavy burden on the spleen and kidneys, and tend to age faster than others, and some chronic diseases will come faster and more than others.

　　Traditional Chinese medicine believes that the accumulation of water and fluid in the body will also form phlegm, and further accumulation of phlegm can become phlegm nuclei, such as scrofula, gall tumor and other diseases; Or form nodules and lumps with blood stasis. In clinical practice, some patients with cyst have reduced curative effect due to improper drinking water, and the curative effect will be obviously improved after changing improper drinking habits.

　　Phlegm drinking and phlegm turbidity are unique concepts of traditional Chinese medicine, which can be divided into tangible and intangible categories. Tangible, sticky is called phlegm, and thin is called drinking. Invisible phlegm and drink can cause many symptoms, such as dizziness, nausea and vomiting, shortness of breath, chest tightness, palpitation or madness, coma, etc., but no substantial phlegm and drink can be seen. Modern medical research has found that phlegm is related to many diseases such as body immunity, hypertension, hyperlipidemia, coronary heart disease, cancer, asthma and mental illness.

　　Four Special Reminders of Drinking Water

　　1. Don’t drink a lot in a short time. Drinking a lot of water in a short time will increase the amount of urination and perspiration. The former will increase the burden on the kidneys, while the latter will cause excessive loss of salt in the body, leading to electrolyte disorder.

　　2. Clear and colorless urine means enough drinking. How to judge whether you have drunk enough water, it is recommended to observe your urine color every day: if it is light lemon color, it means that the water in your body is in the best state; If the urine is clear and colorless, the water intake should be slightly reduced; If the urine is yellow, you need to replenish water in time.

　　3. Don’t drink before and after eating a big meal. People’s stomach space is limited. If you drink a lot of water before or after meals, it will occupy the space, causing abdominal distension and abdominal pain, which is not conducive to gastrointestinal peristalsis and leads to indigestion. Under normal circumstances, it is recommended to drink water half an hour after meals.

　　4. Avoid drinking immediately after long-term exercise. Drinking water immediately after exercise will lead to a sudden increase in blood volume in the body and increase the burden on the heart. A large amount of water stored in the stomach will also affect the rise and fall of diaphragm, causing discomfort such as chest tightness and asthma. It is suggested to sit down and rest for 10 minutes after exercise before drinking water to give the body a buffer time; At the same time, just drink 150 ~ 200ml each time, and don’t drink too much at a time.

　　 China Youth Daily Zhongqing Online Reporter Wang Yejie

　　 If the weather is fine, China’s first domestic civil large passenger plane C919 will start its first blue sky trip on May 5, which marks a major leap in the field of civil aviation in China.

　　 China’s civil aviation industry has been in a state of "buying imported goods" since the research and development of the domestic "Yun Shi" passenger plane stopped in the 1970s.

　　 The turnover of civil aviation passengers in China has rapidly climbed from 23.048 billion person-kilometers in the early 1990s to 727.07 billion person-kilometers in 2015, with a compound annual growth rate of 15%.

　　 C919 was developed in 2008, and now it is about to make its first flight. Every "growth process" of C919 has attracted much attention. Behind this big domestic bird, groups of young talents are also growing sturdily. From the "post-70s" in the early 20th century to the "post-80s" and "post-90s" now, behind the first flight of C919, there is a solid backing composed of young talents.

　　 Data from Commercial Aircraft Corporation of China (hereinafter referred to as China Commercial Aircraft Corporation) show that more than 70% of the company’s young people are under the age of 35. When experts from related international fields visited Comac in China, they expressed such feelings: "The impressive thing about China Big Aircraft is not only the technology, but also the young people who are eager to fly behind it!"

　　The domestic large passenger plane C919 was tested at Shanghai Pudong Airport for high-skid lifting of the front wheels. Xinhua news agency

　　 570 aircraft orders and 60% localization rate

　　 Speaking of C919, I have to talk about the topic of "localization". Fans of the aviation industry may not forget the low standard of "the localization rate is more than 10%" at the beginning of the C919 project, and even this low requirement was considered by some senior aircraft enthusiasts to be difficult to achieve at that time; Today, the finished products delivered off the assembly line not only get 570 orders, but also have a localization rate of nearly 60%.

　　 Some people question that the core engine and other components are all imported. Is the C919 a domestic product?

　　 China Youth Daily Zhongqing Online reporter learned that the nose of C919 comes from Chengdu Aircraft Industry Group, the wing comes from Xi ‘an Aircraft Industry Group, the front and rear fuselage comes from Nanchang Hongdu Aviation Industry Group, and the front section of the rear fuselage comes from Shenyang Aircraft Industry Group.

　　 As for the "kernel" of large aircraft, such as engine, communication and navigation equipment, C919 aircraft chose two paths — — First, foreign original factories and domestic joint ventures; Second, the original import, to a certain extent, to achieve partial domestic, and finally to achieve full domestic.

　　 "Realizing all localization in the end" is the "technical market threshold" set by Comac China when purchasing original imported products. That is to say, once a product is purchased by Comac China, there is only one final "outlet" — — Gradually localized. This is the basic agreement between the product manufacturer and Comac China.

　　 At the beginning of the C919 project, Li Keqiang, Premier of the State Council of the People’s Republic of China set a basic principle for domestic large aircraft — — Independent design, system integration, global procurement, and gradual domestic production.

　　 Many people think that assembling some imported products is actually not too difficult and has no technical content. However, an interview with China Youth Daily and Zhongqing Online reporter found that for China people who have not been exposed to the research and development of civil large passenger aircraft for more than 30 years, the design, production and manufacturing process of C919 itself is full of innovations and challenges.

　　 Take fiber material as an example, 15% of the fuselage of C919 is made of resin-grade carbon fiber material, which is the first time that this material has been widely used in large-scale civil passenger aircraft, and the utilization rate of this material in traditional large-scale passenger aircraft is only about 1%.

　　 Others don’t use it, not because the material is not good, nor because the price is too expensive, but because this material requires too high installation accuracy, ordinary people can’t complete the accuracy required for "docking" with this material, so it is not used much.

　　Gao Yuan (first from the right)

　　 Gao Yuan, deputy director of the aircraft assembly workshop of Shanghai Aircraft Manufacturing Co., Ltd. (hereinafter referred to as Shangfei Company), told China Youth Daily and Zhongqing Online reporter that the resin-grade carbon fiber material used in C919 is light in weight, and its weight can be 80% lighter than that of ordinary traditional materials under the premise of the same strength; Its fatigue life is also longer. Generally, the service life of metallic silver material is 20 years or 60,000 flight hours, but it can reach 30 years or 90,000 flight hours, and the structural life can be increased by 50%.

　　 One problem is that when this material is used in aircraft manufacturing, the docking accuracy required is three or four orders of magnitude higher than that of rockets, and the method of realizing "accuracy" by traditional measuring tools is not applicable.

　　 In the manufacturing process of C919, China people realized the automatic docking of large parts for the first time. Through laser positioning and tracking, the docking accuracy can be two orders of magnitude higher than in the past.

　　 With the "shell", what about the core?

　　 For example, if you cut a small hole in the outer shell of an airplane and fill it with a composite material, to what extent do you think it should be filled? The requirement of C919 is that it is invisible to the naked eye, and the "step difference" between the "patch" and the raw material is within 0.08 mm..

　　Wang Hui (center)

　　 What is the concept of 0.08 mm? It is several orders of magnitude thinner than the thickness of mobile phone film. "Invisible to the naked eye, experienced masters can touch the difference with their hands." Wang Hui, deputy director of the manufacturing engineering department of Shanghai Aircraft Corporation, told the reporter that without a certain technical level, even if a Boeing 747 is disassembled and put in front of you, it is impossible for you to assemble it again.

　　 Wang Hui said that the Manufacturing Engineering Department is equivalent to a translator, and it has to translate the drawings of the upstream aircraft design company into construction plans and technological processes that front-line workers can understand. Even if it is such a small and insignificant step, China people will go abroad to learn from it.

　　 Before C919 started construction, COMAC cooperated with McDonnell Douglas to manufacture aircraft of McDonnell Douglas 82 and McDonnell Douglas 90. In this process, McDonnell Douglas provided the process flow, and COMAC was responsible for the production. To a certain extent, the cooperation with McDonnell Douglas makes the manufacturing engineering department of Shangfei Company grow gradually, and finally it can master the process independently.

　　 Even so, some people will feel disdainful. Isn’t it just to build a shell? How much of the "core" is the result of China people?

　　Zhou Qiwei

　　 Zhou Qiwei, 30, has the most say in this. All the cable-related departments on C919 are under his control and his team’s control. There are 24 of them, with an average age of around 30, but they are responsible for the most critical link in the normal operation of a plane — — 725 cables are arranged and laid, and 150,000 parts are installed and assembled.

　　 These cables, like "nerve lines" and "blood vessels" in the human body, will lead to "organ" failure if they are not careful. The display may not be on, the throttle lever may be out of control, and the joystick may fail … … And all wiring, not a single drawing can solve the problem.

　　 "Drawings are subjective designs, and everything is subject to the real thing." Zhou Qiwei told reporters that wiring often reflects the actual situation to the design team, and many design ideas cannot be realized in the actual wiring process. At this time, the wiring team also has to undertake some "design functions", propose modifications and feedback to the designer, and then wait for the designer to re-issue more realistic drawings. "Without talent, you can’t do this job."

　　 The young and beautiful Gong Wenxiu is also responsible for the control of the "core" inside the aircraft. She is a member of the configuration management team of Shanghai Aircraft Design and Research Institute. Her job is to adjust the technical state of the whole machine to the best before the first flight. The navigation and communication system of aircraft can not be used directly after being bought and installed. It needs constant debugging and constant correction of system errors before it can operate normally.

　　 Gong Wenxiu’s job is to "correct mistakes". Every inspection, she has to carry a thick stack of process specification materials in her hand and check them one by one. She and her team have to evaluate some system functions that cannot be realized for some reason. Why can’t they be realized? What is the impact on the first flight? Is it necessary to achieve it? Then give feedback.

　　Scale testing machine

　　 What does "939, 949" look like after C919?

　　 If the aforementioned "handsome men and beautiful women" are all preparing for the first flight of C919, then the following one is preparing for the future "C939 and C949".

　　 His name is Zhang Chi, deputy head of the future product and technology research team of Beijing Civil Aircraft Technology Research Center (hereinafter referred to as Beiyan) of Comac China. He and his team are responsible for the "future model" of the C919. They gave themselves a rather dreamy name — — Dream studio, responsible for the "Lingque" project.

　　 The "Lingque" project, to put it more popularly, is to design and develop a scaled-down large aircraft. This "Lingque" aircraft is more futuristic, unmanned and small, and the cost of an aircraft is less than 1% of that of the C919. But it carries the future of China’s big plane dream.

　　 Lingque aircraft is a scaled verification model. It costs a lot to build a large plane and bears high risks in the field of innovative technology, but the smaller version of the "Lingque" can be more "dreamy" with low cost.

　　 The latest "Lingque B" fuselage and wings are integrated, which is more economical and comfortable. Its tail has only two pieces, which is less resistant than the general three-piece tail plane.

　　 This team, which is all composed of young people around the age of 30, is now doing research and development to solve the world-wide problems such as expensive air tickets and high fuel consumption of aircraft.

　　Franky Zhang

　　 "Real innovation is not afraid of failure." Zhang Chi said that this team often received suggestions from peers in the past, "Is your plan feasible? Maybe not? "

　　 However, Zhang Chi told reporters that in all kinds of discussions, Dream Studio has made nine scale testing machines since 2012, and there have also been cases in which small planes got out of control after take-off and ground dispatching was unsuccessful. "Without failure, it is not innovation, that is called imitation. We don’t do this. "

　　 Zhang Chi said that youth is the capital of Dream Studio.

　　 China Youth Daily Zhongqing Online reporter learned that Comac China has set up a total of 349 youth commandos, such as the young commandos for aircraft-level joint test of the C919 project of COMAC, and the young commandos for the assembly of the C919 large passenger aircraft system in the aircraft assembly workshop of COMAC, and named 60 youth civilization numbers, such as the composite material/structure research team of the North Research Center and the young technical team for field engineering of the test flight center.

　　 Comac youth played a great vanguard and vital role in the flight test evidence collection of ARJ21 passenger plane, route demonstration operation, design and development, final assembly and manufacturing of C919 large passenger plane, and preparation for the first flight — — Ten youth innovation and entrepreneurship teams, with more than 230 members and an average age of less than 30, have undertaken 37 key technical problems of civil aircraft, including the control law of C919 large passenger aircraft.

　　 Zhongqing Online Shanghai, May 4th