On January 8th, Aouita 11 HarmonyOS version of Zhixiang upgrade was officially launched. The car has mainly undergone four upgrades: intelligent driving upgrade, equipped with map-free NCA function that does not rely on high-precision maps; Comfort upgrade, four somatosensory optimizations; Chassis upgrade, adding Huawei iTRACK function; The rights and interests are upgraded, and the "intelligent" highest rights and interests can be enjoyed for life. Moreover, there is no price increase in the whole department, and the prices of 90-degree rear-drive version 300,000 yuan, 116-degree rear-drive version 335,000 yuan, 90-degree luxury version 350,000 yuan and 116-degree luxury version 390,000 yuan remain unchanged.

With the launch of this car, Aouita has entered the era of intelligent driving with "de-high-precision mapping", which effectively makes up for the shortcomings of the intelligent driving scheme with high-precision maps, not only solves the pain point of "following the map", but also unlocks more high-frequency intelligent driving scenes. It is reported that its urban NCA intelligent driving function will unlock more than 300 cities at one time, bringing users a travel experience of "all the country can open and all the country can open".

Thanks to the industry’s top-stream vehicle-side perception and calculation ability brought by three laser radars that are fully equipped at the beginning, Aouita 11 can land quickly without relying on the intelligent driving NCA function of high-precision maps. Aouita 11′ s intelligent driving system integrates the Road Topology Reasoning Network (RCR) and the industry’s first GOD network to build real-time road information, identify all kinds of obstacles sensitively, and improve the safety of human driving and intelligent driving.

Aouita 11′ s intelligent driving system can make rapid and reasonable vehicle movement planning and path planning, and its driving style is more "human-like". In case of repairing subway, tidal lane, temporary road changes caused by traffic control and other scenes, the intelligent driving system can make up for the difference of iteration period of high-precision maps, and truly drive with or without maps, and the complex road conditions will not be degraded. In response to daily commuting and self-driving cross-provincial travel scenarios, the intelligent driving system can independently choose roads with higher traffic efficiency.

Combined with user feedback, the car has also been optimized for the leg, waist, back and sitting posture of the seat, so that users can have a comfortable experience no matter which seat they are in or which sitting posture they take. At the same time, the chassis of the car is upgraded with Huawei iTRACK architecture, which can realize ultra-fine road condition perception of 10,000 times per second and real-time adjustment of torque of 1,000 times per second, so as to realize the best power output mode under different road conditions and create the best driving experience.

Huawei’s iTRACK function "makes the road smooth". Aiming at the most common speed bump scene in daily life, Huawei iTRACK accurately identifies the wheel speed fluctuation, and adjusts and controls the torque within milliseconds to achieve rapid convergence. Through the actual measurement, the wheel speed fluctuation can be reduced by 50% and the aftershock time can be shortened by 40%, thus effectively improving the comfort and safety of the whole vehicle and bringing better driving experience to users.　

The rights and interests are easy to upgrade. From now until February 29, 2024, car buyers can choose one of the following rights and interests: rights and interests 1. Users who buy cars after January 8 will be given a high-end smart driving bag worth 26,000 yuan; Second, during the activity, car buyers can enjoy the discount of paying a deposit of 5,000 yuan to offset the car payment of 25,000 yuan. In addition, Aouita also introduced more car benefits in a limited time, including: the first car owner’s lifetime three-electricity warranty; 6000 yuan replacement subsidy; Give away the intelligent fragrance system; The down payment starts from 42,000 yuan, and the full-term ultra-low interest financial concessions.

Upstream news Wu Jian

Editor: Wang Xinyu Editor: Kevin·Z Audit: Lei Zhao

　　Recently, the domestic automobile market has ushered in a wave of price reduction. Both fuel vehicles and new energy vehicles have begun to lay down their bodies to earn money, which has also intensified the fierce competition in the market. Therefore, many models have taken the opportunity to usher in updates and upgrades, such as the following three new energy vehicles, which are worthy of attention.

　　Bound M5

　　Manufacturer’s guide price: 259,800-331,800 yuan.

　

　　Although HUAWEI has repeatedly said that it will not build cars, the well-known "AITO Jiejie" has recently become "HUAWEI Jiejie". It can be seen that Huawei has more and more control over the brand of Jiejie. Just recently, the Ministry of Industry and Information Technology has exposed the declaration information of the new model of Jiejie M5, and the new car is expected to add the "Huawei" logo at the tail, so owners don’t have to pick the label!

　
　

　　The main upgrade of the new cross-section M5 is assisted driving. It can be seen from the figure that a laser radar and a full-angle ADAS camera are added above the front of the car, and its computing unit will also be replaced by Huawei’s self-developed MDC, which is not just as simple as changing the standard. In fact, the current cross-section M5 has already achieved L2+ level assisted driving, and the appearance of laser radar will further strengthen its hard power. In the power part, the new car will continue to be equipped with an extended-range hybrid system. Although only two models have been released by the car industry, I have seen many real cars on the road, most of which are the M5, and in January, the M5 ushered in the official price reduction. With the arrival of new models and the increase of configuration, are you optimistic about the performance of the M5 in the next car market scuffle?

　　Tucki P7

　　Manufacturer’s guide price: 209,900-339,900 yuan.

　

　　It’s been three years since Tucki P7 was listed. In the previous era of fuel vehicles, it wouldn’t hurt if it didn’t change the model for three years. However, in the rapidly developing new energy automobile market, various technologies are rapidly iterating, and the competitiveness of P7 is also declining. Therefore, this month, we ushered in an upgraded new Tucki P7i, which will help Tucki to return to the front ranks.

　
　

　　P7i is not just a simple change. It has been upgraded in many aspects, such as vehicle function, comfort configuration, three-electric system, handling performance, intelligent platform, etc. For example, it is equipped with the second-generation intelligent assisted driving system XNGP, and two laser radars are added to the sensor. The intelligent assisted driving chip is equipped with dual Orion-X chips (Xavier in cash), providing high computing power of 508TOPS (30TOPS in cash), which is ultra-high-standard. Secondly, the cockpit hardware was upgraded from 820A to Snapdragon SA8155P, and the interior style was in line with G9. The whole system was equipped with electric suction door, electric tailgate, privacy glass and so on as standard. In addition, in terms of power, the new two-wheel drive version was equipped with a motor of 203 kW/440 N m, and the parameters of the four-wheel drive version were 348 kW/757 N m, which improved obviously in all aspects. However, I think it is more important to launch an entry-level version equipped with a 60-degree battery to lower the price. What do you think?

　

Text: the sound of trees and grass in the forest

　

Proofreading: Chao Gan/Editor: Guo Licheng

　

Houston, an American city no stranger to China, is well-known for its rocket team and space city. People are deeply impressed by its developed petrochemical industry, staggered pipelines and busy factory ports.

　

There are more than rockets and oil behind Houston’s prosperity.

　

(Photo: shutterstock)▼

　

　

But to say that Houston’s most prosperous industry, it has to be the following:

　

The annual output value is as high as $14 billion, more than 90,000 people go to work, and many top medical institutions and researchers gather. By the way, one of the largest medical complexes in the world supports a quarter of Houston’s hotel business.Dezhou medical center.

　

Texas Medical Center "supported" a city on its own.

　

(Photo: Yitu. com) ▼

　

　

This achievement of Texas Medical Center was not achieved overnight, but was a leader in the industrial transformation of the United States for decades. Due to the large number of well-known hospitals gathered here, the supporting medical equipment, industry exhibitions, health consultation and other industries have also developed.

　

Compared with today’s depressed Great Lakes rust belt, Houston is still full of vitality.

　

Industrial explosion in the aging era

　

Houston’s success in the pharmaceutical industry, on the one hand, benefits from the strong strength of universities, scientific research and talents, but as an industry, the most fundamental reason for its rise is stillFundamental transformation of social population structure.

　

76 million people were born in the "baby boom" in the United States from 1945 to 1964, and the average age of the American population has been rising since then. Despite the continuous immigration supplement, compared with the obviously increased elderly population, the incidence of a series of diseases such as diabetes, cancer and Alzheimer’s disease is bound to increase, and the pharmaceutical market is bound to expand.

　

The baby boomers are getting old.

　

Directly raised the average age of the American population ▼

　

　

Aging is not exclusive to Europe and America.With the inevitable trend of economic development and fertility decline, China is no exception.. Moreover, China people’s awareness and demand for health are also obviously improving, which can be seen from the financial market: in the past 20 years, the pharmaceutical and biological industries have increased sevenfold, ranking among the top five in all industries; The scale of biomedical ETF(512290) is also rising step by step.

　

The pharmaceutical and biological industries are growing rapidly ▼

　

　

Biomedical ETF▼

　

　

In the age of aging, diabetes and obesity have become a problem that almost everyone has to face. At present, there are about 537 million people with diabetes in the world aged 20-79. Nowadays, the sale of all kinds of sugar-free drinks and foods on the market is a manifestation of people’s worries.

　

The treatment of diabetes, a chronic disease, is a worldwide problem. Otherwise, there will be no so-called "ancestral secret recipes" flying all over the sky. However,The emergence of GLP-1 drugs will be a blessing for patients..

　

GLP-1 (human glucagon-like peptide -1) is a protein secreted by human intestinal cells, which can promote human insulin secretion. However, GLP-1 secreted by human body is easy to be decomposed by other enzymes, and will not act for a long time. Then, if we improve the structure of GLP-1 so that it is not easy to be decomposed, won’t it promote insulin secretion for a long time and treat diabetes?

　

▼

　

　

Science magazine listed the related research of GLP-1 as the top ten scientific breakthroughs in 2023.Among them, the most famous drug is undoubtedly Smegliptide, which has occupied half of the field of diabetes..

　

(Note: At present, this drug is only approved for the treatment of diabetes in China, but it has not been approved for weight loss! )

　

Smegliptide also shows great potential in the prevention and treatment of Alzheimer’s disease, nonalcoholic hepatitis, cancer and kidney disease, and it is quite aspirin-like "cure all diseases". In October last year, after Novo Nordisk announced the "positive experimental results" of smegliptide in the treatment of diabetic nephropathy, the share prices of many dialysis manufacturers fell. And this story has happened many times in the medical field.

　

The announcement shows that the efficacy of smegliptide has reached the expectation.

　

Therefore, the experiment was terminated early ▼

　

　

Lilly, a pharmaceutical giant, was originally a small company, but relied on its keen sense of smell to take the lead in obtaining insulin patents and monopolize the global market. However, in the 1980s, Novo Nordisk insulin injection pen went on the market, and this convenient and easy-to-use product sold well when it went on the market, which opened the era of hegemony in the diabetes drug market.

　

All these remind people that technology is constantly reshaping this market.An innovative achievement may create a new giant.; Another case is the wave caused by the listing of oral version of smegliptide in China in early 2024.

　

The oral version is also only approved for diabetes treatment.

　

Not approved for general weight loss!

　

(Photo: National Medical Products Administration) ▼

　

　

Massive capital investment and endless new achievements have created a vibrant biomedical industry today. In the past few decades, China, the fastest growing economy in the world, actually has a long-term shortcoming in the biomedical industry.Can you make up this short board?

　

China medicine, difficult to move forward.

　

Taking medicine when you are sick is something that everyone has to experience. However, the expensive drug price has become a pain in patients’ hearts. The dilemma in Dying to Survive may happen to each of us.

　

The reason why the drug price is so high is related to the current high cost of drug research and development:10 years, 1 billion dollars. For a long time, the pharmaceutical industry has been dominated by a group of large multinational pharmaceutical companies. On the one hand, it has high research and development costs and technical barriers. On the other hand, monopoly status means strong pricing power. Such a market situation has created amazing profit margins for large pharmaceutical companies: in 2023, the annual sales of smeagoutide reached $21.142 billion.

　

Novo Nordisk Meglumine Peptide Related Products Financial Report ▼

　

　

The pharmaceutical industry in New China originated from the eldest son of the Republic medicine-Shijiazhuang Huabei Pharmaceutical FactoryThe first batch of domestic penicillin in China was born here. However, due to our late start and weak foundation, we have never had any industrial advantages except for traditional Chinese medicine products with local characteristics for a long time. When foreign pharmaceutical companies with strong R&D strength and mature business model enter China, they are like wolves in the flock. If they don’t catch up, the pharmaceutical market of more than one billion people will be completely lost.

　

Chinese medicine is a symbol of moderns in Shijiazhuang ▼

　

　

At that time, China’s R&D ability was very weak, so we could only start with the production of basic raw materials for drugs. The ingredients of the raw materials are fixed, and the production process is relatively mature. As long as you are willing to do it, you can produce products. But the middle and lower reaches of this international industrial chain can receive a large number of orders only because of low labor costs. Moreover, the technological level was limited at that time, and the pollution in the production process was very serious.

　

This is obviously not a long-term solution. The vast market of all kinds of new drugs attracts China enterprises. Since they can’t make high profits in developing new drugs, let’s start with generic drugs and get a slice of the huge market first. Nowadays, many backbone enterprises in the pharmaceutical industry in China (such asHengrui Pharma, the heavyweight stock of biomedical ETF), it is in these two waves that the initial accumulation has been completed and it has moved to the upper reaches of the industrial chain.

　

From generic drugs to self-developed drugs

　

Enterprises need a certain amount of time to accumulate and precipitate.

　

(Photo: Picture Worm Creativity) ▼

　

　

At this time, the pharmaceutical industry in China has made great progress. But after all, I still follow in the footsteps of others, and I only earn a fraction of the big international pharmaceutical companies. If you really want to gain a foothold in the biomedical industry, you need to come up with your own things and change the old thinking and industrial model as a whole.Only by thoroughly remoulding oneself can we really grow up.

　

It is not only an economic and commercial issue to enlarge the local pharmaceutical industry. Even in the era of high globalization, the regional differences of health problems in different countries need the developed biomedical industry in their own countries.

　

For example, the Texas Medical Center mentioned at the beginning

　

Has the largest cancer center in the United States

　

(Photo: MD Anderson)▼

　

　

For example, due to the differences of environment and living habits in different countries, the incidence of cancer, the big health killer in the aging era, is different in different countries. The incidence of lung cancer and nasopharyngeal carcinoma in China is obviously higher than that in Europe and America, and esophageal cancer patients account for half of the world. Only by establishing an independent biomedical industry system can we better provide targeted treatment for patients.

　

Make your own medicine

　

Cancer, in most people’s minds, is equated with terminal illness. But the progress of modern medicine is enough to make this an old yellow calendar.

　

One of the major difficulties in cancer treatment is that cancer tissue has a strong ability to deceive, and it will "hide" itself under the guise of the identification mechanism in the human immune system to prevent cannibalism. In other words, if drugs can be used to "remind" the immune system and "catch the mole", it can play a role in preventing and treating cancer.

　

"There is a mole, terminate the transaction."

　

(T cells surround identified cancer cells)

　

(Photo: NICHD/J. Lippincott-Schwartz)▼

　

　

Research in this field has been carried out for decades, among whichPD-1/PD-L1 has attracted much attention from scientists.. Cancer cells will suppress T cells through this in vivo inhibitor, making it think it is a "friendly army". Scientists have developed drugs to block the inhibitory signal pathway between T cells and tumor cells, so as to "restart" the human anti-cancer mechanism.

　

Microscopically, PD-L1 positive lung adenocarcinoma cells

　

(Photo: wiki)▼

　

　

Such drug development requires high technology and in-depth study of human immune system. In the past, it was estimated that multinational pharmaceutical companies developed and sold high prices, and then domestic pharmaceutical companies waited for the patent period to pass a wave of imitation. However, times have changed.

　

By the end of 2023, 17 PD-(L)1 products have been approved for listing in China market, of which more than half are domestic products. In addition to PD-1 target, drugs such as PARP and CDK4/6 have also been successfully developed. Hengrui Pharma is one of the most important manufacturers in this field in China. Its biopharmaceutical products cover lung cancer, nasopharyngeal carcinoma and other high-risk cancer categories in China, and a large number of drugs are in the clinical research stage.

　

Some cancer-related drugs in Hengrui Pharma.

　

(Photo: Hengrui Pharma) ▼

　

　

But at present, the human response rate of PD-(L)1 drug is not high enough, and scientists are still improving it.

　

Since antibodies can recognize tumor tissues, people naturally think: Can you directly use it with chemical drugs to accurately find cancer cells and give him a "total annihilation"? After all, no matter how hard you work, you are afraid of a kitchen knife: no matter how tough a cancer cell meets a high dose of chemical drugs, it will only disappear.

　

Schematic diagram of the action mechanism of antibody-coupled drugs

　

(photo: ADCREVIEW)▼

　

　

This is antibody-based coupled drugs (ADC), which is one of the main anticancer drugs at present.. The principle is simple, but there are many difficulties in research and development: how do protein primers connect with "toxins" that attack cancer cells? How to ensure that you don’t play your medicine too early on the way to the "enemy camp"? How to "exit" in case of entering normal cells of human body? As a result, ADC drugs with complex structures have become research and development black holes. Once the research and development fails, it is difficult to find out which link has a moth.

　

How to design the parts of antibody conjugates

　

It is a big problem to maximize the drug effect ▼

　

　

In the past, this was the natural technical moat of large multinational pharmaceutical companies, which could greatly increase the price of drugs; But now, this is still the stage for China pharmaceutical companies to show their fists:At the end of 2023, BL-B01D1, an ADC dual-antibody drug for lung cancer and breast cancer, was developed by Bailey Tianheng, which set a record for China drugs to go to sea. Successfully went to sea with a down payment of $800 million and a potential price of $8.4 billion..

　

China’s biomedical industry has not only quickly caught up with the world-class phalanx, but also achieved a leading position in some fields.

　

Bai Li Tian Heng represents China Biomedical Haoheng.

　

(Photo: Bai Li Tian Heng) ▼

　

　

Both PD-1 and ADC use drugs to enhance the immune cell ability of human body or kill cancer cells. Then, directly enhancing the recognition ability of human immune cells can also achieve anti-cancer effect? It sounds like science fiction, but it has been realized in reality: using genetic engineering technology to inject receptor genes that can recognize the corresponding tumor cell antigens into immune T cells, so that they can accurately identify cancer cells. This is the CAR-T cell therapy technology.

　

Process diagram of CAR-T cell therapy technology

　

(Photo: MUSC)▼

　

　

At present, CAR-T is mainly used for the treatment of hematological cancers, including well-known leukemia. There are only ten models on the market in the world, and China has four models, including Regiosai injection of Wuxi PharmaTech, which is heavily held by biomedical ETF. In addition to the treatments already on the market,There are hundreds of CAR-T therapies being developed in China, the largest number in the world..

　

China’s bio-pharmaceutical industry, which once could only follow the big international pharmaceutical companies, has finally grown up.

　

Reggiorense injection is the second CAR-T product approved in China.

　

It is also the first CAR-T product of Class 1 biological products in China.

　

(Photo: Wuxi PharmaTech) ▼

　

　

The overall progress of this industry is inseparable from the joint efforts of this huge industrial chain. The listing of any drug requires sufficient clinical trial evidence and approval of relevant departments. For a long time, the approval speed of new drugs and new medical devices in China is slow, and a large number of drugs to be approved often pile up. In the high-speed development of drug research and development track, any time delay will miss business opportunities.

　

Since August 2015, the State Council issued the Opinions of the State Council on Reforming the Examination and Approval System of Medicines and Medical Devices, and a series of reform measures have been introduced one after another. In 2019, the newly revised Drug Administration Law established the MAH system for listed licensors, which mobilized the enthusiasm of more new drug research and development. The response of the market and industry is also extremely rapid, and various breakthroughs of biomedical enterprises in China have emerged in succession.

　

The core of MAH system is to separate drug marketing license from drug production license.

　

Allow pharmaceutical production enterprises, R&D institutions or researchers.

　

Become an independent drug marketing license holder

　

(Photo: Drug Administration Law) ▼

　

　

Go out to sea and look to the future.

　

The breakthrough in the related fields of innovative cancer drugs is only one aspect of the rapid progress of the biomedical industry in China. With the deepening of people’s cognition, medicine is more than just taking medicine to see a doctor; The future medicine will be a whole from genes to society. The biomedical industry in China is also making all-round progress.

　

Biomedicine in China is making efforts.

　

(Photo: Yitu. com) ▼

　

　

Since the 21st century, people have made many breakthroughs in cancer treatment. But no matter how to treat it, it is a process of suffering for patients. It would be best if it could be prevented.

　

At present, the human papillomavirus vaccine (HPV) is the only vaccine that has an obvious preventive and therapeutic effect on cancer (cervical cancer). Originally, it was expensive and all of it relied on imports. Many cities were in short supply and even went to Hong Kong to fight. nowDomestic bivalent HPV vaccine has been put on the market, and the cost of vaccination has been greatly reduced..

　

Bivalent HPV vaccine independently developed and produced by watson biological.

　

A needle costs less than 400 yuan.

　

(Photo: released by Kunming) ▼

　

　

People’s recognition of domestic vaccines is real.Zhifei Bio and watson biological held by Biomedical ETF.They all rely on relevant vaccine products to achieve good results in the capital market. It can be expected that this market will continue to grow after the domestic nine-valent vaccine is listed around 2025.

　

▼

　

　

　

Under the constant technical update,The pharmaceutical industry will continue to reshuffle and opportunities will continue to emerge..

　

An unprecedented wave of aging has arrived, and the biomedical industry with long-term sustainable development potential is undoubtedly the biggest outlet under this trend. Houston Medical City has proved to us that this industry has unlimited potential and long-term stability, and it is also a great opportunity for the city to realize industrial transformation. For individual investors, this is a win-win choice to support national health and obtain stable investment income; For practitioners, the market is changing with each passing day, and there are many opportunities but fierce competition.

　

To win the hard bones in the field of medicine, we need to unite from policy to market, as well as various therapies and all directions. Various fields with great prospects will gradually merge into one. It should be only a matter of time before China has its own world-class medical center.

　

Swipe up and down to view references:

　

Arnold, C., Webster, P. 11 clinical trials that will shape medicine in 2024. Nat Med (2023).

　

Chau, C.H., P.S. Steeg, and W.D. Figg, Antibody-drug conjugates for cancer. Lancet, 2019. 394(10200): p. 793-804.

　

Hao
MM, Stamp LA. The many means of conversation between the brain and the
gut. Nat Rev Gastroenterol Hepatol. 2022 Dec 14. doi:
10.1038/s41575-022-00725-4. Epub ahead of print. PMID: 36517617.

　

Hu
Y M , Guo M , Li C G ,et al.Immunogenicity noninferiority study of 2
doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine
In Girls vs.3 Doses in Young Women [J]. China Science: Life Sciences English Edition, 2020, 63(4):10.

　

Lu
Z, Chen Y, Liu D, et al. The landscape of cancer research and cancer
care in China. Nat Med. 2023; 29(12):3022-3032.
doi:10.1038/s41591-023-02655-3.

　

Majzner
R G , Mackall C L .Clinical lessons learned from the first leg of the
CAR T cell journey[J].Nature medicine, 2019,
25(9):1341-1355.DOI:10.1038/s41591-019-0564-6.

　

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A, Hinder M, Dodel A, Gassmann O, Hartl D. Investigating the origins of
recent pharmaceutical innovation. Nat Rev Drug Discov. 2023
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Wiener CM, Wang Qing, Yin Kanhua. "From gene to society" —— Design logic and implementation process of the new curriculum system of Johns Hopkins University School of Medicine [J]. Fudan Education Forum, 2012 (3): 7. DOI: 10.3969/j.ISSN.1672-0059.2012.03.

　

Zheng
J , Xie Y , Ren L ,et al.GLP-1 improves the supportive ability of
astrocytes to neurons by promoting aerobic glycolysis in Alzheimer’s
disease[J].Molecular Metabolism,
2021:101180.DOI:10.1016/j.molmet.2021.101180.

　

Li Wenshuo. Medical Industry and Urban Renewal: the Transformation Road of Pittsburgh, an American Industrial City [J]. Qiushi Journal, 2017,44 (6): 7. doi: CNKI: Sun: qsxk.0.2017-06-022.

　

Li Zhenying. On the transformation strategy and policy of Pittsburgh, the American "Steel Capital" [J]. Journal of Quanzhou Teachers College, 2009 (03): 82-86. DOI: 10.3969/j.ISSN.1009-8224.2009.03.016.

　

Pan Wenzhuo, Cao Yongkang. Historical investigation of urban renewal in the United States-taking Pittsburgh as an example [J]. 2019.

　

Ye Xiaozhen, Shao Jiaqing. Progress in clinical application of smegliptide [J]. Chinese Journal of Diabetes, 2022,14 (Z1): 1-8. DOI: 10.3760/CMA.J.CN115791-20220721-00353.

　

Yin Junxiang,. High-tech Park Leading Regional Economic and Social Development —— Development Experience and Enlightenment of Texas Medical Center in the United States [J]. Outlook of Global Science and Technology Economy, 2015,(07).

　

National Health and Wellness Committee of People’s Republic of China (PRC), Guidelines for Diagnosis and Treatment of Diffuse Large B-cell Lymphoma (2022 Edition).

　

2023
BREAKTHROUGH OF THE YEAR. Retrieved December 14, 2023 from
https://www.science.org/content/article/breakthrough-of-the-year-2023

　

* The reference to individual stocks is for reference only and does not constitute investment advice.

　

* The content of this article is provided by the author and does not represent the position of the Earth Knowledge Bureau.

　

Cover: Yitu. com

　

END

　

　

　　In 2020, under the catalysis of the epidemic, star live broadcast with goods became one of the key words of this year’s industry.

　　Since April, there have been more and more stars with live broadcasts. According to incomplete statistics, more than 100 stars, including Liu Mintao, Amanda, Zheng Shuang, Chris Lee and Z.TAO, appeared in the live broadcast room or e-commerce parties on major platforms in the recently concluded 618 Shopping Festival. And stars including Wang Han, Tamia Liu and Michael Chen have opened their own live broadcast rooms, and started to do live broadcast with goods alone.

　　From the "re-employment of dead stars" to the arrival of many stars, live broadcast with goods has gradually become a new outlet in the industry. However, what is the effect of star with goods?

　　From a little low to a craze,

　　Live broadcast with goods into a star "sideline"

　　Before this year, there seems to be a natural and insurmountable gap between live broadcast and stars. Last June, Ada had a live broadcast with goods on a live broadcast platform. During the activity, she stood with online celebrity, the head of the platform, shouting and selling goods. This live broadcast with goods made Ada board the hot search, which was followed by the ridicule of netizens.

　　At that time, the stars who went to live broadcast with goods were closely connected with the word "out of breath", so most of the stars and star teams were resistant to live broadcast with goods, and fans would feel that it was a bit low for their idols to live broadcast with goods.

　　But what I never expected was that in the past year alone, star live broadcast with goods has become a trend, and some netizens even joked that "at present, the live broadcast platform has propped up half of the entertainment circle".

　　Beginning in April, CCTV News launched a special live broadcast of public welfare goods, and CCTV hosts and artists such as Zheng Shuang and Wong Cho Lam joined in one after another. "CCTV boys" also created a good result of more than 500 million turnover in three hours; In May, Tamia Liu launched a live broadcast with goods in Taobao as the "Chief Optimization Officer of Juhua Cost-effective", and the sales in three hours reached 148 million; In June, the hit variety Sister Braving the Wind and Waves cooperated with Tik Tok, and many "sisters" in the program will appear in the live broadcast room for a total of 12 live broadcasts with goods.

　　In just one year, everyone’s attitude towards live broadcast with goods has changed so much. What do the stars really like about live broadcast with goods before they are willing to put down their posture and enter the live broadcast with goods?

　　To some extent, the "incarnation" of the stars is the result of market demand. In the past two years, the film and television industry has been hit hard, especially the epidemic situation has made the film and television winter worse, the start of the crew has shrunk dramatically, and the job opportunities of the stars have collectively decreased. The offline content is blocked, and all walks of life have turned to "online". The live broadcast of goods above the tuyere can be said to be the hottest publicity exposure at the moment, opening up a new path for the stars who are "waiting for employment". According to the Beijing News, waist artists’ income from a brand live broadcast is generally six figures, which is higher than that from participating in a variety show recording, and they can also get corresponding publicity resources, which can be described as killing two birds with one stone.

　　At the same time, e-commerce and short video platforms have also shown an embrace attitude towards the live broadcast of stars with goods, and launched a series of support policies to vigorously attract star users. For example, Taobao Live launched the "Star Start Plan" and gradually increased the intensity of introducing stars; After Tik Tok invested the resources of the whole station to make the live broadcast with goods in Luo Yonghao the first shot, it attracted more stars to join the ranks.

　　From the occasional guest promotion to the opening of the live broadcast room, the star with its own traffic enters the game, and the platform is naturally happy. Last year, only some stars who had no burden took the lead in testing the water. For example, Li Xiang changed his Weibo name to "anchor Li Xiang" and threw himself into the live broadcast craze. For example, stars such as Wong Cho Lam and Aaron Kwok parachuted into online celebrity’s live broadcast room. This year, it has become a visible trend for stars to sink and live with goods.

　　Live delivery is actually a "technical activity"

　　The reason why the platform attaches importance to the live broadcast of stars with goods is that stars can bring traffic and attention to the platform and accelerate the destruction of the circle. This year, the epidemic has also brought a big impact to the e-commerce platform. According to the data, in the latest quarterly report, compared with the previous quarter, Alibaba’s revenue fell by 7.55%, JD.COM fell by 14.3%, and Pinduoduo plunged by 39.4%.

　　As a result, Taobao Live invited 300 stars to start the tide of star goods; Poly-cost-effective, together with Tamia Liu, Jing Tian, david lee and other stars, entered the live broadcast ecology with 10 billion subsidies; JD.COM Live took the "Beijing Consumer Season" as an opportunity to invite a number of well-known hosts to bring goods in the form of recommenders. For a time, e-commerce platforms have been laid out to seize star resources.

　　The addition of stars has indeed played a role in stimulating traffic and realizing sales transformation to a certain extent. In the following table, the first show record of live broadcast of stars with goods is sorted out, among which Zhang Ting, who has been working hard in the e-commerce industry for many years, won the first place, and stars such as Yuqi Zhang, Hua Shao, Wang Han and Tamia Liu also created the first show sales exceeding one trillion.

　　However, as can be seen from the table, there are only a few stars who can take the lead, and it is not easy for most stars to do live broadcast with goods. Even if these stars bring their own traffic, it may be more fans and people who eat melons than real consumers who gather in the live broadcast room. Therefore, compared with koL, the head of the live broadcast platform, the data of the stars’ goods is obviously dim. Even though the stars tried their best to imitate the various words of the head anchor and threw away their baggage and shouted "Buy in buy buy" in the live broadcast room, many stars were labeled as unsuitable.

　　Lin Yun started his first show with goods in Taobao live broadcast room, "Jelly Lin premiere, allow you good things". According to the data of melon, 888,700 people watched UV in a single live broadcast, with 26,000 pieces of goods sold, and the peak number of online users was only 17,100. Li XiaoLu’s debut with goods also frequently overturned. When introducing products, I almost read them according to the manuscript, and I also misspoke the price of the products. I am not familiar with the goods I brought, so I can only rely on the anchor friends to help me.

　　Therefore, at present, most e-commerce platforms still adopt the relatively safe operation mode of "star+anchor", which combines the specialty of the anchor with the traffic topic of the star. However, for some stars, they are unfamiliar with products and lack of professionalism, which makes them a "tool person" who politely cooperates with the anchor. It is inevitable that they are somewhat embarrassed.

　　Is it a long-term good business to bring goods live by stars?

　　At present, most stars participate in live broadcast with goods, or cooperate with the anchor in the form of "airborne" live broadcast or holding activities, not as a profession as the anchor, and the star live broadcast with goods is still in the exploration stage. Moreover, although the live broadcast of the stars brings high exposure to themselves to a certain extent, at the same time, a series of problems such as live broadcast rollover and follow-up product quality caused by unfamiliar business are also likely to cause a crisis of public trust in the stars.

　　On the one hand, the stars increase their exposure through the current hot e-commerce live broadcast, narrow the distance with fans, and establish an affinity for people, thus further circling the powder. In the previous live broadcast of Li Jiaqi and Yang Mi, Li Jiaqi was accused by netizens for her improper speech, while Yang Mi’s response to high emotional intelligence in the live broadcast made many netizens’ impression of her change; When Jin Jing, a comedian, visited the live studio in Li Jiaqi, she not only explained the products skillfully, but also made funny jokes one after another. Many netizens joked that "even Li Jiaqi will lose his job".

　　On the other hand, the live broadcast of stars with goods is also very likely to cause controversy, which will have an impact on their own performing arts. Frequent exposure consumes its own influence. If the stars frequently bring goods live, the audience will gradually get used to the appearance of them shouting "buy it, buy it" in the live broadcast room. When they return to their own performing arts career, the audience may find it difficult to get into the show for a while. The rollover phenomenon in live broadcast, such as high price, quality problems and after-sales situation, not only affects product sales and loses more and more consumers, but also may affect the audience’s evaluation of their personal image and works.

　　In addition, regardless of the ability to carry goods, the live broadcast itself has certain risks. Once the car rolls over, it will bring negative effects to itself, and even ruin one’s acting career. Zhai Tianlin, who doesn’t know HowNet, and Tong Zhuo, who changed his identity from "previous student" to "new student" by some means, are the best examples.

　　In the market environment where the film and television industry has not yet recovered, there may be more stars moving towards the road of live broadcast with goods. However, with more and more stars entering the market, consumers will tend to be rational sooner or later, and the bonus brought by the star aura will gradually decrease. At that time, the threshold of "live broadcast with goods" will be raised accordingly. Without the title of "star", I am afraid it is difficult to win the "killing" in the live broadcast of rivers and lakes.

　　— THE END —

　　Author | Li Yang

　　Editor | Yang Ni

1905 movie network news The film directed by, starring, and starring is being shown. The national roadshow of "Hot Search" and "Sound All the Way" came to Shenzhen, where director Xin Yukun and actor Song Yang exchanged views with the audience after the screening. At the event site, some spectators enthusiastically launched a "Cantonese class", and Song Yang’s subwoofer version of Cantonese once ignited the atmosphere.

After watching the movie, some viewers engaged in the media industry felt deeply, saying that they were deeply moved by Chen Miao’s initial news, and frankly said, "I am also engaged in the news industry, and I have a great sense of substitution for movies, and I burst into tears when I reversed." Director Xin Yukun shared that it is the journalist’s sense of responsibility and mission that drives Chen Miao forward. "I hope that after watching the movie, everyone can return to life and online public opinion and pass this power on.". Song Yang also said, "I hope this film will bring warmth and strength to the audience. When we speak for the victims rationally, we are the flame led by Chen Miao".

The situation of women resonates. "The blood pressure in front is soaring, and the gas can be seen in the back."

The mother felt the same way and bluntly said, "We need more Chen Miao."

In the film, director Xin Yukun depicts rich and vivid female group images from a delicate perspective. Some viewers felt that "the situation of women in the movie is too realistic. In the first half, the blood pressure soared, and later it was very deflated", which praised the ending of the movie. Director Xin Yukun said, "The reality is very cruel. We can usually see many women’s plight, and at the same time we can also see generate, a woman with strength. I hope to bring this strength to everyone.".

There was also a mother audience at the scene, who was poked by Zhang Xiaosui’s mother in the movie because of the helplessness of reality. "As parents, we should protect our children more consciously. Reality and network are complicated, and we need more people like Chen Miao." Shi Rui, who plays Hu Qiao, also shared the mental journey of the role. She left the Justice Team precisely because she stood in the female perspective and understood more about the helplessness and powerlessness of Xiaomou’s mother. Compared with justice, the child’s life is the deepest concern of a mother.

Children are full of emotion: when they grow up, they must not be "keyboard man"

The truth of public opinion is a wake-up call, "We must speak rationally in the future."

The sharp presentation of the film to the real online public opinion has also made many viewers think deeply. After watching the movie, some viewers said, "It used to be easy to be rhythmic. After watching the movie, I always told myself to be based on reality, and I must speak rationally. I hope all the truth can be revealed and the bad guys can be severely punished." Director Xin Yukun said, "I want to convey the power of women, truth and partners through this film, and I hope everyone will still have confidence in the world after watching it.".

A second-grade child said excitedly after watching the movie, "I must not be a keyboard man when I grow up!" " Children’s words detonated the scene, and the main creators praised him one after another, encouraging children to "study hard and join the justice team in the future." Xin Yukun, the director, said, "I hope everyone can feel the power we convey, and let the powerless be strong and the pessimists move forward.".

The film "Hot Search" is showing.

　　Source: WeChat WeChat official account "China Youth Publishing House" (ID: CYPG 1963), Author: Chen Zhangle (Editor-in-Chief of China Youth Publishing House)

　　People need a little spirit, and a country and a nation need a little spirit. The power from the spirit is the most surging, lasting, noble and great.

　　For more than 5,000 years, the Chinese nation has created a long and splendid Chinese civilization with great creative spirit, great struggle spirit, great unity spirit and great dream spirit.

　　Since the birth of the Communist Party of China (CPC), under the leadership of the Party, under the guidance of Marxism, under the guidance of the lofty ideal of communism and the dream of the great rejuvenation of the Chinese nation, generate, a son of the Chinese nation, has made great strides and written a series of brilliant movements with a sense of earth-shaking, earth-shaking and earth-changing in the grand process of revolution, construction and reform in China.

　　The power of spirit needs to be inspired, recorded, spread, inherited and promoted by spiritual products.

　　Classic series of "Three Reds and One Creation" (Red Rock, Red Sun, Red Flag Spectrum and Entrepreneurship History) by China Youth Publishing House.

　　"Three Reds and One Creation" in the History of Publishing and Youth Spirit in New China — — Classic books such as Red Rock, Red Sun, Red Flag Spectrum and Entrepreneurship History have created a group of heroes such as Jiang Jie, Xu Yunfeng, Shen Zhenxin, Zhu Laozhong and Liang Shengbao, who, under the leadership of the Communist Party of China, are constantly pursuing, struggling, selfless dedication and fearless sacrifice for national independence, people’s liberation, national prosperity and people’s happiness.

　　According to the novel Red Rock, the film Eternal Life in Fire shows Xu Yunfeng (Zhao Dan) and Jiang Jie (Yu Lan).

　　这些主人公是无数革命先烈、英雄人物、党和人民好儿女的化身；他们的故事是一代又一代中国共产党人和中国人民追梦筑梦故事的缩影；他们身上体现的强大精神力量，感染、感召、鼓舞、激励着一代又一代中国青年投身党和人民伟业，在为实现站起来、富起来、强起来而努力拼搏中创造无悔的青春。

　　今年初以来，面对新冠肺炎的突然来袭，广大青年响应党和人民召唤，毅然站出来，勇敢冲在第一线。在援助武汉、湖北的医护人员队伍中，在突击建设雷神山、火神山和方舱医院的队伍中，在奔波于各个岗位的志愿者队伍中，在驻守社区村镇防护检疫的基层干部群众队伍中，在穿梭于各个街道小区、守护经济社会生活正常运行的快递小哥队伍中……到处都可以看到“90”后甚至“00”后在奋战奉献的身影。

　　习近平总书记在给北京大学援鄂医疗队全体“90后”党员的回信中，赞扬“在新冠肺炎疫情防控斗争中，你们青年人同在一线英勇奋战的广大疫情防控人员一道，不畏艰险、冲锋在前、舍生忘死，彰显了青春的蓬勃力量，交出了合格答卷”，指出“广大青年用行动证明，新时代的中国青年是好样的，是堪当大任的！”

　　The approval of the general secretary makes the vast number of young people feel extremely proud, and it is also the endless driving force for youth struggle!

　　What is the future of the country like the youth.

　　Youth has spiritual strength, and the country has a future.

　　We are proud to see that in today’s younger generation, the classic power of "three reds and one innovation" is being passed on, the national spirit is shining, the ideals and beliefs are shining, and the excellent quality is shining!

　　On this special year’s World Book Day, let us reread the classic of "Three Reds and One Creation" once again, so that our hearts can gain a full energy and let us hold high the ideal sail of youth and forge ahead in the new era!

　　1. Pay attention to the WeChat WeChat official account of "Central Committee of the Communist Youth League" and "China Youth Publishing House". Welcome to leave a comment at the end of the article, and write down your story with the books in the "Three Reds and One Creation" series, your thoughts on youth responsibility, etc. According to the comprehensive ranking of the quality of comments and the number of likes, the top 20 readers on each platform will get a book related to comments (activity time: April 23, 2020 — May 5, 2020).

　　2. Pay attention to the headline numbers of "Central Committee of the Communist Youth League", "China Youth Publishing (Head Office)" Weibo and "Central Committee of the Communist Youth League" today, and forward the relevant content lottery.

　　Let’s act quickly! (The list of books will be published on China Youth Publishing House WeChat WeChat official account on May 6, 2020. )

　　Editor’s note:Water is the source of life and is vital to human health. Drinking water can promote the body’s metabolism and absorption of nutrients, but drinking it wrong may be harmful to health. Therefore, how to drink water is very particular. Let’s take a look.

　　The misunderstanding of drinking water is constant

　　Last summer, the northern hemisphere continued to suffer from high temperature, and the number of patients with "water poisoning" in hospitals in many regions of Europe doubled. According to the Danish Local Times, some Danes drank a lot of tap water to cool off the heat, which caused them to get sick. Take Hawkbell Hospital as an example, the number of patients with "water poisoning" this summer is 10 times that of previous years. According to local doctors, drinking too much water will increase the water content of blood and reduce the sodium content, which will lead to the imbalance between salt and water. Severe imbalance may cause "hyponatremia", and patients may have brain swelling, headache and other phenomena, and even lead to epilepsy, shock and death.

　　Zhao Feihong, director of the Health Drinking Water Professional Committee of Beijing Health Protection Association, said that when people sweat a lot, in addition to water loss, many electrolytes mainly sodium salts will also be discharged with sweat, and people often drink a lot of water to replenish water. This is a misunderstanding. Drinking pure water alone can’t replenish the missing electrolyte, and even further dilute the electrolyte concentration, which leads to the imbalance of the ratio of water and electrolyte in human body and triggers the body to produce different degrees of stress response. "However, in general, drinking more water will not cause serious problems ‘ Poisoning ’ Only people with poor kidney and cardiopulmonary function need special attention. "

　　Zhao Feihong said that there are still many misunderstandings about people drinking water. First, drinking water too fast and replenishing a large amount of liquid in a short time will increase the burden on organs such as the heart and kidneys, which may easily lead to headache, edema and elevated blood pressure. Second, drinking water is too "ice". When the body temperature is high, it is best not to drink drinks below 5℃. Drinking cold water will stimulate the stomach and lead to stomach cramps and diarrhea.

　　Water accounts for 60%~70% of human body weight, and plays an important role in forming whole body tissues, regulating body temperature, promoting metabolism of various systems of the body, and assisting absorption, transportation and excretion of various substances. Batman, an American doctor of medicine, recorded many studies in the book "Water is the Best Medicine", which proved that healthy drinking water can relieve hypertension, diabetes, allergies, asthma, cancer and other diseases. He once cured more than 3,000 patients with water.

　　How to drink water correctly

　　When you feel thirsty, the water loss of adults is about 2% of your body weight, and that of children is about 2%~5%. At this time, your body functions begin to be affected. Lack of water can also lead to loss of appetite, depression, dry skin, hoarseness and general weakness, which can be life-threatening in severe cases. Zhao Feihong suggested that you should develop the habit of taking the initiative to drink water, and don’t wait until you are thirsty. Drinking water should follow the principle of "small amount and multiple times": 100~150 ml is suitable for each time, and the interval is about half an hour; Drinking water with a small mouth is more thirst-quenching than pouring water with a large mouth, which is beneficial to human absorption.

　　There are four best times to drink water. After getting up in the morning, around 10 am, 3-4 pm and before going to bed at night, it is currently recognized as the four "best drinking periods" in a day.

　　Zhao Feihong explained that people do not drop water during sleep, and the formation of nocturia and the loss of water through breathing and skin make the body in a physiological state of water shortage, which leads to the increase of blood viscosity and the accumulation of metabolites in the body. Therefore, drinking a glass of water half an hour before going to bed can alleviate the above phenomenon and reduce the risk of cerebral thrombosis. Drinking a glass of water after getting up in the morning takes only 20 seconds, and water can enter the blood, which makes the blood dilute rapidly and improves the water shortage at night.

　　At least 1.5 liters per day. According to Dietary Guidelines for China Residents (2016), the recommended daily drinking water for adults is 1.5~1.7 liters. Gu Chuanling, deputy secretary-general of the Capital Health Food Nutrition Society, said that people’s daily drinking water can be appropriately increased according to the following factors:

　　1. Living environment. In hot weather, people sweat more and lose water faster, so it is necessary to increase water supply. It is easy to dry in autumn and winter, and in the heating room in northern winter, the water evaporates quickly, so it is necessary to increase the amount of drinking water.

　　2. Dietary factors. The diet is salty, and when the human body discharges excess salt, it needs to consume more water; If you eat food containing more protein, your blood osmotic pressure will increase slightly, and you need extra water to excrete the urea produced by protein. At these times, you need to pay attention to drinking more water.

　　3. Physical condition. When a cold has a fever, the human body will lose a lot of water in the form of sweating, so it is necessary to increase the amount of water.

　　Boiled water is best.

　　China Nutrition Society recommended that boiled water is the most suitable drinking water for human body. American scientists have found that when the boiled tap water is cooled to 25~30℃, the chlorine content is the lowest, and the biological activity of the water is also increased. It can easily penetrate the cell membrane, which can promote the body’s metabolism, enhance immune function and improve the body’s disease resistance.

　　Sweet drinks, functional drinks, fruit juice, strong tea and coffee can’t completely replace drinking water. Zhao Feihong said that all kinds of sweet drinks and fruit juices are high-sugar and high-calorie drinks. The human body needs to consume more water to complete metabolism and cannot replenish water well. Functional drinks, strong tea and coffee all contain caffeine, which has diuretic effect in itself and is not conducive to human hydration.

　　Special people pay attention to drinking water

　　Children. Dietary Guidelines for China Residents, Balanced Dietary Pagoda for Preschool Children in China and Dietary Guidelines for School-age Children in China suggest that the water demand for children under 10 years old varies with age: 6 months to 1 year old, and the total daily water intake is 900 ml (milk/food+drinking water); 1~2 years old, the total water intake is 1300 ml (milk/food+drinking water); 2~3 years old, drinking 600~700 ml; 4~5 years old, 700~800 ml; 5~7 years old, 800 ml; 7~10 years old, 1000 ml. Gu Chuanling reminded that children’s initiative to drink water in time is generally poor, and they like to drink sweet drinks. Parents should do a good job of monitoring and remind their children to drink water in time.

　　Lactating women. About 90% of milk is water, and milk secretion is closely related to the daily intake of water. Drinking more water under the condition of ensuring balanced nutrition is beneficial to milk secretion. Gu Chuanling said that they are generally recommended to drink more water than ordinary women, about 2.1 liters per day.

　　Old man. Old people tend to urinate frequently, and if they don’t drink water regularly, they are prone to thick blood and high blood fat, which will eventually cause a series of metabolic diseases. Therefore, the elderly should drink water frequently, and the amount of drinking water should be increased accordingly, which can be judged according to the color of urine: if the urine is light yellow, 250 ml of water should be replenished in time; If it is brown, it means that the body is seriously short of water, and you should drink 500 ml of water.

　　Office workers. Office workers can replenish 200 ml of water in time after arriving at the company every day, which is conducive to promoting brain activity and working concentration. In addition, office workers who sit indoors for a long time are prone to get fat. Drinking 200 ml of water half an hour before meals is conducive to increasing satiety and reducing food intake to some extent.

　　Manual workers. Athletes and outdoor workers need to replenish water in time after a lot of physical activities. Zhao Feihong suggested that these people can properly replenish water about half an hour before physical activity. During the activity, they can replenish water with a small amount of water. After the activity, they are not in a hurry to replenish water. After a while, they can replenish water and drink some light salt water appropriately.

　　Poor spleen and stomach, drink less water.

　　It is recorded in the medical book "Four Sages Heart Source" in Qing Dynasty: "Shui Gu enters the stomach, the spleen and yang are grinded, and the dregs are passed down, but for feces drowning, the essence is served, and it becomes qi and blood." If the spleen yang is insufficient (spleen yang is the function of spleen and stomach), the digestion and absorption of water is weak and it cannot be turned into qi and blood. People with poor spleen and stomach, such as loss of appetite, nausea and vomiting, frequent hiccups, abdominal distension and diarrhea, epigastric discomfort and other symptoms, had better drink less water in the morning to avoid further affecting the function of spleen and stomach.

　　Be careful when drinking water because of lung dysfunction.

　　Traditional Chinese medicine believes that besides breathing, another important function of the lung is "attending festival", including "dredging water channels". "Waterway" refers to the way that water and liquid move, that is to say, the lung can regulate the metabolism of water and liquid, mainly through the spreading and descending of the lung, and transport body fluid to all parts of the body by using lung qi, which can also promote the water and liquid to be lost to the bladder, so as to keep urine flowing smoothly. If lung function is impaired, such as frequent chest tightness, shortness of breath, wheezing and palpitation, cough with excessive phlegm, nasal congestion and runny nose, etc., water metabolism will also be poor, and drinking water indiscriminately will aggravate symptoms.

　　Traditional Chinese medicine believes that the kidney controls water and the bladder controls the gasification of water. Kidney plays a key role in regulating and maintaining water-liquid balance in the body. If there is a problem with kidney function, pay more attention to drinking water, otherwise there will be edema and unfavorable urination. When there is no need for drinking water, don’t force yourself to drink water, but keep your body in a state of peace of qi and blood.

　　Drinking too much water increases the burden.

　　Many chronic patients have thick blood and hope to dilute it by drinking more water. In fact, water can’t enter blood vessels immediately. Traditional Chinese medicine believes that the human body is a circular whole, and the metabolism of water should be completed under the coordination of various organs and tissues. If there are problems in the gasification of triple energizer, the transfer of viscera and the operation of qi and blood, water will not achieve the purpose of diluting blood, but will increase the burden on the heart, lungs, spleen and kidney. Dietary Guidelines for China Residents (2016) suggests that the daily drinking water should be kept at 1500~1700 ml.

　　Huang Yuanyu, a famous doctor in the Qing Dynasty, said: "If qi does not turn into water, it will stagnate on the upper side and become phlegm; if water does not turn into qi, it will stop accumulating on the lower side and become drinking. Generally speaking, yang deficiency leads to soil failure, and the golden water is swollen, all of which have the disease of retention of phlegm and retention of drink. Covering the phlegm and drinking, corruption and stagnation hinder the road of qi and blood around the week, and the spirit of the spirit is close to the aid. All diseases start and the changes are constant. " It means that if there is no yang, such as yang deficiency and spleen deficiency, and lung and kidney are not transported, water will stagnate into phlegm and form phlegm-drinking disease. Phlegm can block the circulation of qi and blood, leading to many diseases. People who often drink too much water have a heavy burden on the spleen and kidneys, and tend to age faster than others, and some chronic diseases will come faster and more than others.

　　Traditional Chinese medicine believes that the accumulation of water and fluid in the body will also form phlegm, and further accumulation of phlegm can become phlegm nuclei, such as scrofula, gall tumor and other diseases; Or form nodules and lumps with blood stasis. In clinical practice, some patients with cyst have reduced curative effect due to improper drinking water, and the curative effect will be obviously improved after changing improper drinking habits.

　　Phlegm drinking and phlegm turbidity are unique concepts of traditional Chinese medicine, which can be divided into tangible and intangible categories. Tangible, sticky is called phlegm, and thin is called drinking. Invisible phlegm and drink can cause many symptoms, such as dizziness, nausea and vomiting, shortness of breath, chest tightness, palpitation or madness, coma, etc., but no substantial phlegm and drink can be seen. Modern medical research has found that phlegm is related to many diseases such as body immunity, hypertension, hyperlipidemia, coronary heart disease, cancer, asthma and mental illness.

　　Four Special Reminders of Drinking Water

　　1. Don’t drink a lot in a short time. Drinking a lot of water in a short time will increase the amount of urination and perspiration. The former will increase the burden on the kidneys, while the latter will cause excessive loss of salt in the body, leading to electrolyte disorder.

　　2. Clear and colorless urine means enough drinking. How to judge whether you have drunk enough water, it is recommended to observe your urine color every day: if it is light lemon color, it means that the water in your body is in the best state; If the urine is clear and colorless, the water intake should be slightly reduced; If the urine is yellow, you need to replenish water in time.

　　3. Don’t drink before and after eating a big meal. People’s stomach space is limited. If you drink a lot of water before or after meals, it will occupy the space, causing abdominal distension and abdominal pain, which is not conducive to gastrointestinal peristalsis and leads to indigestion. Under normal circumstances, it is recommended to drink water half an hour after meals.

　　4. Avoid drinking immediately after long-term exercise. Drinking water immediately after exercise will lead to a sudden increase in blood volume in the body and increase the burden on the heart. A large amount of water stored in the stomach will also affect the rise and fall of diaphragm, causing discomfort such as chest tightness and asthma. It is suggested to sit down and rest for 10 minutes after exercise before drinking water to give the body a buffer time; At the same time, just drink 150 ~ 200ml each time, and don’t drink too much at a time.

This is the week of change. Seven days may not change many things, but your body begins to experience positive changes. The first experience of running will cause your heart rate to increase, blood will flow through your body quickly, and excess fat will start to burn.

Even if your legs feel sore, you will feel inexplicably comfortable after running, because running will make the pituitary gland secrete the happy hormone endorphin-just like the feeling of love, running will bring you a good mood for the day and a more relaxed attitude towards life, which will make you feel different scenery along the way.

After running for a month, your breathing will become even and stable, and your heart will become steady and powerful. You should have lost a lot of body fat, and some clothes and pants feel a little bigger. And your living habits are quietly changing, you will find that it is no longer difficult to go to bed early and get up early.

People around you will find that your mental state has improved. Before you moved a little, you would be out of breath. Now you can run faster than others even if you trot to the canteen for dry meals. Running brings you a different spirit!

You will find that you have hardly been to the hospital this year. Running can make your immune system full of vitality. Physical condition and endurance have been greatly improved. A lower heart rate and smoother breathing mean a more effective cardiopulmonary system. The distance you can run casually may be beyond most people’s reach.

Running brings you high-speed metabolism. With a healthy diet, fat will no longer accumulate. Compared with the chubby bodies of many people around you, your body and physical condition are beyond their level. The annual physical examination will not tremble, and there will be no dense arrows on the report card.

Keep running and love sports. Everyone will think that you are a persevering and trustworthy person, because you will work hard for a goal and focus on making yourself more persistent. Everyone likes a person who is persistent, aggressive and dare to work hard. Runners bring their own aura of sunshine, health and progress.

Stick to running, form the habit of running regularly, and live a self-disciplined life. Go to bed early at night and don’t stay up late; Eat on time, take a shower after running, sleep better and live more regularly. Unconsciously, your living habits will naturally change. You have rarely overeated, eaten lightly, stayed away from junk food and paid more attention to nutrition.

Many people of the same age have begun to decline, and various minor problems appear frequently, but your figure is always standard. Although you are stronger and bald, maybe your hair will be a little less, but it is nothing compared with those uncles and aunts who are out of shape.

Long-term persistence in running has created a healthy and good physical condition, and also exercised a tenacious spiritual character. Running for five years is the best education for children, and the spirit of never giving up in the end has become his belief in a subtle way. Running has become a part of your life. Keeping running is not to beat anyone, but to find a better self!

Long-term running can eliminate free radicals harmful to human body and delay the aging process. Your body shape, appearance, physical strength and spiritual temperament are second to none among your peers. You will find that your physical condition is not inferior to that of young people, and your proud physical strength and endurance may even have a real contest with the back waves. You can continue to live a good life healthily in the next 10, 20 and 30 years!

If you have been running for 10 years, you will definitely feel the changes brought by every step you take. If you haven’t run for 10 years, then stick to it and believe me, you will meet a better yourself!

Is running easy? Of course it is simple!

Everyone can run.

Is it difficult to run? It is also very difficult!

After all, I want to run well and fast.

Need a lot of secrets ~

You can try the following eight short-term trainings. These methods not only help to break the stereotyped training methods, but also canRaise your speed and endurance to an all-time high.

I want to introduce you today.assort or arrange in pairs or groupsPractice methodChoose one of the first three running methods (1~3) for training in the first half week, and then choose one of the four to seven running methods for training in the second half week. Just choose the last running method on weekends.

These training methods come fromEd Ashton-Master of Sports ScienceTwo-time Olympic marathon runner and head coach of the men’s cross-country team of Brigham Young University.

1) Rhythm running

concept: An accelerated version of 4-mile jogging, the running rhythm keeps "the difficulty that the body can adapt".

causeRhythm running training can get rid of the metabolic wastes in the body that cause muscle "burning sensation" and thus force you to slow down. Therefore, you can work harder and last longer.

wayEstimate the fastest time to complete 3 miles (about 4.83 kilometers). Calculate the speed per mile and add 30 seconds to it.So, if you think that the fastest speed for running 3 miles is 24 minutes (that is, 8 minutes per mile), you can try to run 4 miles (about 6.44 kilometers) at a rhythm speed of 8 minutes and 30 seconds per mile.

point outKeep accurate speed control and wear a watch.

2)1000-meter rhythmic running

conceptComplete a series of 1000-meter runs at a rhythmic speed, with breaks in between.

causeShort-distance rhythmic running can help you maintain a strictly fixed speed, while short-term recovery can keep you at a high energy level.

wayRun 1000 meters (about 2.5 laps of the standard runway) at a rhythm speed of 4 miles (about 6.44 kilometers) (the speed determined in "1. Rhythmic Running"), then rest for 60 seconds and repeat. At the beginning, I ran 1000 meters intermittently for 6 times, and then increased it once every time I performed training, and gradually upgraded it to 10 times.

point outIf you like, you can also measure time instead of distance. Run for 3.5 minutes at a time, and then rest.

3) Tolek downhill running.

conceptFrench Tolek is Swedish for "arbitrary speed change", which means that you can speed up and slow down according to your own feelings. Very "European" way.

causeIn the French-Tolek downhill running, the interval is more structured, which is a very American way, and the last stage of running will become more difficult. If you train harder when you are tired, you will run faster when you are full of energy.

way：The starting speed is about 75% of the maximum effort and lasts for 5 minutes. Then slow down to about 40% for 5 minutes. Continue this fast-first-then-slow mode, but reduce the running time by one minute each time and increase the speed. In the last minute of the explosion, the speed should be close to the sprint.

point outIncrease the first stage by 1 minute every week, but continue to perform the same deceleration sequence until the first interval runs for 10 minutes.

4)1 mile cycle run

concept: Many hard 1 mile (about 1.61km) runs, with breaks in between.

causeThe length and intensity of the 1-mile cycle run force you to reach the edge of your aerobic limit, and enhance your endurance and willpower, which are necessary qualities for long and hard running.

wayRun 3 or 4 1-mile (about 1.61 km) intervals at the speed of 5 km race. After each mile, rest for 4 minutes.

point outBudget your physical strength so that you can finish every quarter mile (about 0.4 km) at the same speed.

5)800-meter circular running

conceptTry to run as fast as you can with jogging to recover your strength.

causeThe best way is to run with maximum oxygen uptake.

wayWarm up until you sweat. Subtract 10 seconds from the speed of 1 mile (about 1.61 km) running cycle, and maintain 800 meters (equivalent to 2 standard runways) at this speed. After each 800-meter run, jog around the track before repeating.

point outAt the beginning, run 4 times in each training class, and then increase it once in each training class until you can finish 8 times without being forced.

6)400-meter cycle running

conceptTry to run as fast as you can with jogging to recover your strength.

causeTrain your ending acceleration ability.

wayRun at your fastest 1 mile (about 1.61 kilometers) (if your personal record of 1 mile, abbreviated as PR, is 7 minutes, you need to finish 400 meters in 105 seconds or 1 minute and 45 seconds). After each 400-meter run, jog for 1 or 2 minutes, and then repeat. At the beginning, there were only six interval training runs in each training class, and then one interval was added every time you stepped onto the runway for training, until it increased to 10 trips.

point outCount the time before you start. And warm up first!

7) Cross running method

conceptThe fast run alternated with the 200-meter slow run, running a total of 2 miles (about 3.22 kilometers).

cause：This training forces you to recover from running and allows you to train longer distances with higher overall intensity, which other training methods can’t provide.

wayRun 200 meters at your personal record speed of 1 mile (about 1.61 kilometers), then slow down and finish the next 200 meters at a rate of 10 seconds more. Continue to alternate between these two speeds until you run 2 miles (about 3.22 kilometers).

point outIf the speed decreases during the fast running or jogging stage, resulting in more than 2 seconds in the fast or slow running, run the whole 2 miles at an easy speed.

8) Accelerated long-distance running in the second half

conceptLong-distance running with rapid speed in the second half.

causeAfter training, your body can stick to a long distance, and you can accelerate in the later course and rush the line more forcefully.

way: Double the distance you can run normally and easily. Run half at your normal speed first, and increase the speed at the halfway point to shorten the time to complete each mile by 5 to 10 seconds.

point outStore or carry some water to help you finish the second half of the distance.

– END –

The above part comes from

Running without Injury and Women’s Fitness Book

Authorized by People’s Posts and Telecommunications Publishing House.

-End-














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