On July 24th, Beijing Yaojiayuan, the first brand-new AITO authorized user center in Beijing, was officially opened! At the same time, a test drive of the M7 was held. Many car owners and friends participated in the opening ceremony and test drive experience, and visited the AITO Authorized User Center Beijing Yaojiayuan.

Ride the wind and waves to start a new journey

AITO Authorized User Center Beijing Yaojiayuan Store is the first batch of authorized user centers with a brand-new image in China and the first in Beijing. After 10 months of preparation, after numerous adjustments and polishing of the project plan, repeated scrutiny of the design drawings, continuous selection and comparison of construction materials, it was successfully completed under the influence of many factors such as epidemic shutdown. With a construction area of nearly 4,000 square meters, AITO Automobile Authorized User Center Yaojiayuan Store provides customers with one-stop service integrating sales, experience, delivery and service, and is committed to providing users with higher quality service and car purchase experience. At the same time, it also has industry-leading standard functions, image and hardware supporting facilities, as well as a professional first-line team.

The opening ceremony officially began, and many media users congratulated the successful completion of the user center. After the meeting, all the leaders and guests at the AITO Authorized User Center Yaojiayuan witnessed the appearance of the second heavyweight flagship model of AITO-Wenjie M7 and the in-depth test drive experience.

Luxury wisdom is worthy of the name.

As a brand-new high-end new energy vehicle brand created by Cyrus and Huawei and deeply empowered by Huawei. AITO not only inherited the technical accumulation of Cyrus in building cars, but also injected the genes of Huawei’s scientific and technological wisdom. Since the first M5 appeared on the market on December 23rd last year, it has won high recognition from the market for its outstanding performance in design, intelligence and luxury. Nowadays, it has two flagship models, and the latest model, the M7, came out on July 4th, and created an excellent record of the fastest delivery of a new brand single model.

Excellent achievements stem from excellent quality. The M7 body of Wenjie continues the family design language of AITO brand, and the iconic hexagonal grille and eagle wing penetrating taillights are highly recognizable. AITO zero-gravity seat adopts zero-pressure sensing ergonomic design to create a seat back cushion with ultra-uniform pressure distribution and create an experience beyond luxury MPV.

The whole vehicle is equipped with HUAWEI DriveONE pure electric drive extended range platform. It is a 1.5T four-cylinder range extender 3.0 specially built for the extended range system, and one liter of oil can generate 3.13 kWh. The dual-motor four-wheel drive system combines the maximum output power of 330kW and the acceleration of 4.8s per 100 kilometers. With the carefully adjusted all-aluminum chassis and suitable wheelbase design, the comfort and sportiness are perfectly unified, bringing a flowing driving experience.

The M7 also brought a brand-new upgraded HarmonyOS intelligent cockpit, giving the M7 convenient multi-device interconnection capability. The new super desktop function allows the mobile phone application to directly access the M7 car, and the mobile phone can be operated through the big screen, which greatly facilitates the user’s car experience.

Ask M7 to open a happy test drive.

In the joyful atmosphere of the opening of the new store, Yao Jiayuan started the M7 test drive experience in the world. This test drive gives users a deep and comprehensive test drive experience through the combination of dynamic and static tasting and road props test drive. In addition to the car show, the static tasting area also has exquisite tea breaks and band interaction, which adds warmth and interest to the test drive. In the dynamic test drive, in addition to the road test drive, a variety of props appear in the prop test drive area, making the single test drive more diversified.

In the highly competitive new energy track, in addition to the competition of vehicle strength, service has become a core competitiveness of today’s market. Under the guidance of AITO automobile brand, AITO authorized user center Yaojiayuan Store will open up a brand-new and smarter service world for the majority of car owners, and AITO will continue to move forward and bring smarter car life to consumers.

A few days ago, Xiaobian obtained a set of real car maps of Chery’s upcoming new flagship SUV, a new car or named Tiggo 9, to locate a medium-sized SUV. Based on the new T2X Mars architecture, the new car is available in five/seven-seat versions and equipped with a 2.0T Kunpeng engine, which is expected to be unveiled in the first half of 2023. Next, let’s take a look at this new car.

Chery tiggo 9

First of all, let’s take a look at the power part that everyone cares about. Chery Tiggo 9 is expected to be equipped with Chery Kunpeng 2.0T turbocharged engine. If it is true, this new car can far exceed the same displacement engine in performance. Referring to the power parameters of Tiggo 8, the maximum power is 254 HP and the peak torque is 390 Nm. It is worth mentioning that the new car will apply the 8AT transmission independently developed by Chery for the first time in terms of transmission system, which is compatible with the four-wheel drive system.

Looking at the appearance, Chery Tiggo 9 still has a strong family design language. The large-size front grille with straight waterfall and polygonal LED headlights on both sides make the overall design personalized and highly recognizable. It is worth noting that this new car, as a brand-new flagship SUV model, is still in line with the positioning. Although a new generation of consumer users are now pursuing youth and sports, in terms of overall style, Chery Tiggo 9 still takes a calm and atmospheric route.

Coming to the side of the car body, the new car adopts a two-color body design with a black suspended roof and a hidden door handle, which highlights the sense of movement of the vehicle. The design of the tail adopts a relatively simple and atmospheric design, and the through taillight group is matched with the central CHERY letter logo, so the overall design is still highly recognizable. Although the body data of the new car has not been released yet, we can still see that the new car has a good space performance and the slender shape is very prominent.

At present, the interior of Chery Tiggo 9 has not been exposed. Refer to spy photos, or use curved double large screen, equipped with HUD head-up display, and put on a brand-new three-position flat-bottomed steering wheel with touch buttons to further increase the scientific and technological atmosphere. If the friends who are interested in this new car remember to pay attention to the car online review first, then Xiaobian will lead everyone to know the latest news.

It is worth noting that Chery Group released the latest sales data. According to statistics, Chery Group sold 100,531 vehicles in November. From January to November this year, the cumulative sales volume was 1,127,289 vehicles, a year-on-year increase of 32.6%. Among them, 406,540 vehicles were exported during the year, a substantial increase of 70.9%.

In terms of brand segmentation, Chery Automobile sold 70,788 vehicles in November and accumulated 844,010 vehicles from January to November, up 45.8% year-on-year. Specific to the models, the global sales of the tiggo 8 and tiggo 7 models of the SUV tiggo series from January to November this year were 171,000 and 146,000 respectively.

Auto Network Comment: Chery Tiggo 9 will help Chery Automobile to develop continuously.

Chery’s achievements are obvious to all of us. Its development in recent years can be described as sustained and steady growth, and it has been breaking through its own achievements. At the same time, it has been building good cars. According to official information, up to now, Chery Group has 11.13 million users, including more than 2.35 million overseas users. This time, the new flagship SUV Chery Tiggo 9, Xiaobian believes that it can help Chery Automobile to continue to develop. We still don’t know about the pricing of new cars. I wonder how much you think is appropriate? Welcome to leave a message ~

　　Speaking of domestic pickup trucks, I believe everyone’s first reaction is that it not only has a domineering appearance, but also has excellent technology and strong performance, as well as a huge audience. It took only two years to win the sales performance of 200,000 units. The family members of the gun can be described as dazzling, from the passenger version to the commercial version; From gasoline version to diesel version; From two-wheel drive to four-wheel drive models, there are even more than 30 versions.

　　This time, with the help of Chengdu Auto Show, the gun family has added a new member, that is, the cross-country gun Everest version. This off-road test drive is also carried out around this new car, and there are also artillery and off-road guns present. Next, let’s walk into the jungle from the city and feel the off-road style of pickup trucks. Of course, before the test drive, let’s learn about the differences between these three cars.

　　In terms of appearance, the Everest version of the off-road gun uses a rougher metal bumper and wheel eyebrows, and also uses the exclusive 8848 gray, which is matched with 18-inch wheels and AT tires, which is also a perfect interpretation of the off-road gun. Artillery is the main hard-core toy style. After being equipped with the hard-core equipment of off-road guns, meeting consumers with more dexterous body sizes will definitely make people shine.

　　The change of the interior is not too big, and the classic design is still adopted, which does not lose the sense of atmosphere and technology in practice.

　　In terms of seats, guns never disappoint people. Although there will be serious injuries in the second row, it doesn’t mean that the design department of the Great Wall will make up for the congenital defects with more substantial filling.

　　Summary:

　　At this test drive meeting, the gun also introduced another family member "Motorcycle Gun", which is also the first model specially built for motorcycles. The scene was only statically displayed. As for its performance, it will not be truly experienced until the car is listed.

　　As a single product model, the gun may be just a pickup truck to other brands, but for the Great Wall, the gun is completely a "base", and it can even be said to be like Transformers. As long as you dare to think about it, there is nothing that the gun can’t do, such as motorcycle version, off-road version, travel version, electric version, etc. So many versions have been evolved to meet the individual needs of every consumer for pickup truck models. We have witnessed the growth of Cannon since it went on the market for two years, and we sincerely hope that it can get better and better and become an instant hit in the global market as soon as possible!

Mr. Li: I want to buyVolvo XC60For the 2023 model, we had a good chat earlier. She said to pay 10,000 yuan in advance. I asked if this could be refunded. She said it could be refunded, so I was relieved to pay.

Mr. Li said that the landing price negotiated by both parties was more than 350 thousand. He provided a voucher for transferring 10,000 yuan to the 4S shop, but it did not reflect the nature of the money.

HangzhouYongda Yongwo Volvo 4S Store Sales Xiaojing: The customer said that I brushed the intention money, but I said no, we brushed the deposit of 10,000 yuan.The deposit is not an intentional deposit.I have confirmed that I said this. Then he said, shouldn’t you make a contract first? I said we are signing it electronically now.

journalist: Did you mention that you could return it?

Hangzhou Yongda Yongwo Volvo 4S Store sells Xiaojing.：At that time, it was like this. I said that you had to brush up the money first, and then an electronic version of our contract would be published. I would add the things I gave you on it. If there is something different, you can return it without signing it, provided that there are different circumstances.

Mr. Li: at that time, weDidn’t say anything about intention money or deposit.This statement means whether you can pay this 10 thousand yuan first.

Meng Supervisor, Sales Department of Hangzhou Yongda Yongwo Volvo 4S StoreXiao Jing seems to be signing the contract for you. You can take it with you that day.

Mr. LiBut I didn’t see it until the contract, and it said the deposit.

journalist: Bao hijab?

Mr. LiYes, but before that, we didn’t make it clear that it was a deposit. I began to discuss with my family at that time. In fact, when I came, I had the lowest floor price in my heart, but I didn’t reach it here.

Mr. Li said that he was in a hurry at that time, so heNo electronic contract was signed.. Not long after he left the store, he offered a refund to the sales, which was rejected.

Mr. Li: I suggest you do business, open such a big store and do such a big business. Every customer of yours should be treated sincerely. You didn’t mean to make your customers pay, and then we will come here and talk, I think.Although your store is large, your pattern is not large.I think all of you have this situation.

Hangzhou Yongda Yongwo Volvo 4S Store Wu JingliThe customer said that he couldn’t wait for a few minutes because he was going to have a parent-teacher meeting, so he left first in a hurry. If he didn’t leave that day, these subsequent ambiguities might not occur. I think there are some ambiguities in the communication between the customer and us during the sales process.

The 4S shop emphasized that what Mr. Li paid was the deposit, and the decision of the hijab was generally non-refundable.

Hangzhou Yongda Yongwo Volvo 4S Store Wu JingliFrom the point of view of sales, the deposit paid is the guarantee of both parties. The first is to ensure that the rights and interests enjoyed by customers in our store remain unchanged.

journalist: Then, in this process, why did you tell him that you can return it?

Hangzhou Yongda Yongwo Volvo 4S Store Wu Jingli：You can return it without prompting. Don’t worry about this question, Mr. Li.

Mr. LiWhat you said are all things that the transaction has been completed!

Mr. Li thinks that he didn’t sign it, and the deposit contract is not established, and he demands a full refund. However, Wu Jingli still hopes to continue to serve Mr. Li, saying yesSpecific car prices can be negotiated as appropriate..

Mr. LiIn fact, before I entered the store, my expectations were clearly communicated with her, and the number of naked cars should not exceed 350,000. Although in the process of communication, they added something to make me feel that it met my expectations at that time, because there was no sign at the scene, when I calmed down and thought about it, I actually felt that I still did not meet my main demands.

Hangzhou Yongda Yongwo Volvo 4S Store Wu JingliIs our service not in place, or is there something wrong with our price negotiation?

journalistCan I return it to him?

Hangzhou Yongda Yongwo Volvo 4S Store Wu Jingli：If the customer really doesn’t want to buy it for this reason …

Mr. Li: How many days have I been arguing now?

Hangzhou Yongda Yongwo Volvo 4S Store Wu Jingli：I don’t want to negotiate the price.

Later, Wu Jingli gave feedback,Agree to refundFor Mr. Li.

    International Online auto channel News: On August 18th, the new brand of Great Wall Gun was officially released, which opened the era of pickup truck riding and globalization in China. The Great Wall Gun will be user-centered, and create a full-scene pickup truck life through super products, super services, super experiences and the "Great Wall Gun Alliance" plan. At this press conference, the pickup truck for the Great Wall Gun was officially opened for pre-sale, with the pre-sale price of 126,800-159,800. From now until September 30, users who paid a deposit of 999 yuan will enjoy a five-fold respect gift.

   

Li Ruifeng, Vice President and Sales Company Manager of Great Wall Motor Co., Ltd.

   The Great Wall artillery sword refers to the top three in the world, making pickup trucks popular.

    Driven by consumption upgrading and demand upgrading, pickup trucks ushered in spring. The Great Wall Gun brand released this time is the first global pickup truck brand in China, which will open the prelude to a new generation of global pickup trucks and reshape the global pickup truck power map.

Zhang Jiaming, general manager of pickup brand of Great Wall Motor Co., Ltd.

    In the future, Great Wall Gun will compete with Toyota, Ford and other international mainstream pickup brands in the global market, accelerate the globalization process in an all-round way, and reach the "1-2-3" strategy, that is, keep domestic and export sales absolutely first; By 2020, the annual sales will exceed 200,000; In 2025, the cumulative global sales exceeded 3 million.

    The release of the pickup truck for the Great Wall Gun has fully launched the "one gun and three rings" plan, that is, taking users as the center, creating a full-scene pickup truck life through super products, super services and super experiences.

   

Group photo of Great Wall Gun Alliance

    At this conference, Great Wall Gun established the "Great Wall Gun Alliance" in conjunction with outdoor clubs, modified brands, sports brands and non-profit organizations, taking users as the center, building an open and shared pickup life community and creating the "strongest ecological circle" of pickup culture. Members of the Great Wall Gun Alliance will realize the open sharing of marketing promotion, peripheral products, space and user circles, and gather various forces to promote pickup culture and make pickup popular.

   Great Wall Gun, Redefining the Life Style of Pickup Truck

    The brand-new logo of the Great Wall Gun evolved from the letter "P", which represents the triple meanings of "POWER strength and strength", "PK challenge and innovation" and "PERFECT perfection and extreme life", and symbolizes the spiritual connotation pursued by the Great Wall Gun. The Great Wall Gun is a label, representing those elites who yearn for freedom, are fearless of challenges, pursue perfection and have distinctive characteristics of the times!

   

Great wall pao Logo

    The Great Wall Gun has the comfort of a car, the off-road nature of an SUV, the leisure nature of a station wagon, and the loading and versatility of a light truck, so that it can be used by four cars with one car. The Great Wall Gun provides not only comfort in riding, but also a relaxing experience in spirit, vision and mind.

   

Zhang Haobao, Marketing Director of Pickup Truck of Great Wall Motor Sales Company

   126,800-159,800, the pickup truck for the Great Wall Gun was pre-sold.

   

Pre-sale price of great wall gun

    At the press conference, the Great Wall Cannon opened the pre-sale of the pickup truck for passengers, and the user opened it on August 18, 2019 — On September 30, 2019, users who paid a deposit of 999 yuan through Great Wall pickup trucks in official website, JD.COM and Tmall Great Wall Motor flagship stores can enjoy five gifts:

    Exclusive gift: give away the trunk lid (hard top or shutter flat cover)

    Financial Gift: Enjoy 2 years of zero-interest financial support.

    Replacement ceremony: enjoy a maximum replacement subsidy of 5,000 yuan.

    Interconnection ceremony: basic services are free for life, entertainment services for 3 years and exclusive services for 1 year.

    Alliance ceremony: Enjoy all the service rights and interests of the Great Wall Gun Alliance (long-term value-added rights and interests).

   

Group photo of the Great Wall Gun Conference

    The Great Wall Gun is built on the new P71 platform of Great Wall Motor, which is safer, more comfortable, lighter and more extensible, and can be derived from more than 100 models with different sizes, different power and different driving forms.

   

Interior Design of Great Wall Gun

    In terms of passenger configuration, 6-way main driver’s electrically adjustable seat, seat electric heating, dual-temperature zone automatic air conditioning, more than 100 sound insulation/sound absorption treatments, and multi-link rear suspension applications.

    The new car networking technology is adopted to realize functions including intelligent voice control, intelligent dynamic information service, etc. It is equipped with L2-level automatic driving technology, matching ACC adaptive cruise, lane keeping, intelligent driving assistance and other functions, and can realize functions such as assisted driving, environmental awareness, planning and decision-making.

   

Design of great wall cannon head

    The pickup truck for the Great Wall Gun is equipped with 8AT+2.0T engine, TOD intelligent four-wheel drive, high-strength cage body of the whole vehicle, ESP with the latest generation of Bosch 9.3 version, 360-degree look around, reversing image, parallel assistance, intelligent forward looking, 12 radar probe, etc.

    The birth of the Great Wall Gun means that the Great Wall pickup truck is accelerating the globalization process in an all-round way, opening the era of pickup truck utilization, leading the pickup truck culture with China characteristics and impacting the top three pickup truck brands in the world. The whole scene pickup truck life circle will definitely bring users a more colorful super experience. (Photo courtesy of Great Wall Motor Editor Wei Wei Editor wuyue)

　

Text: the sound of trees and grass in the forest

　

Proofreading: Chao Gan/Editor: Guo Licheng

　

Houston, an American city no stranger to China, is well-known for its rocket team and space city. People are deeply impressed by its developed petrochemical industry, staggered pipelines and busy factory ports.

　

There are more than rockets and oil behind Houston’s prosperity.

　

(Photo: shutterstock)▼

　

　

But to say that Houston’s most prosperous industry, it has to be the following:

　

The annual output value is as high as $14 billion, more than 90,000 people go to work, and many top medical institutions and researchers gather. By the way, one of the largest medical complexes in the world supports a quarter of Houston’s hotel business.Dezhou medical center.

　

Texas Medical Center "supported" a city on its own.

　

(Photo: Yitu. com) ▼

　

　

This achievement of Texas Medical Center was not achieved overnight, but was a leader in the industrial transformation of the United States for decades. Due to the large number of well-known hospitals gathered here, the supporting medical equipment, industry exhibitions, health consultation and other industries have also developed.

　

Compared with today’s depressed Great Lakes rust belt, Houston is still full of vitality.

　

Industrial explosion in the aging era

　

Houston’s success in the pharmaceutical industry, on the one hand, benefits from the strong strength of universities, scientific research and talents, but as an industry, the most fundamental reason for its rise is stillFundamental transformation of social population structure.

　

76 million people were born in the "baby boom" in the United States from 1945 to 1964, and the average age of the American population has been rising since then. Despite the continuous immigration supplement, compared with the obviously increased elderly population, the incidence of a series of diseases such as diabetes, cancer and Alzheimer’s disease is bound to increase, and the pharmaceutical market is bound to expand.

　

The baby boomers are getting old.

　

Directly raised the average age of the American population ▼

　

　

Aging is not exclusive to Europe and America.With the inevitable trend of economic development and fertility decline, China is no exception.. Moreover, China people’s awareness and demand for health are also obviously improving, which can be seen from the financial market: in the past 20 years, the pharmaceutical and biological industries have increased sevenfold, ranking among the top five in all industries; The scale of biomedical ETF(512290) is also rising step by step.

　

The pharmaceutical and biological industries are growing rapidly ▼

　

　

Biomedical ETF▼

　

　

In the age of aging, diabetes and obesity have become a problem that almost everyone has to face. At present, there are about 537 million people with diabetes in the world aged 20-79. Nowadays, the sale of all kinds of sugar-free drinks and foods on the market is a manifestation of people’s worries.

　

The treatment of diabetes, a chronic disease, is a worldwide problem. Otherwise, there will be no so-called "ancestral secret recipes" flying all over the sky. However,The emergence of GLP-1 drugs will be a blessing for patients..

　

GLP-1 (human glucagon-like peptide -1) is a protein secreted by human intestinal cells, which can promote human insulin secretion. However, GLP-1 secreted by human body is easy to be decomposed by other enzymes, and will not act for a long time. Then, if we improve the structure of GLP-1 so that it is not easy to be decomposed, won’t it promote insulin secretion for a long time and treat diabetes?

　

▼

　

　

Science magazine listed the related research of GLP-1 as the top ten scientific breakthroughs in 2023.Among them, the most famous drug is undoubtedly Smegliptide, which has occupied half of the field of diabetes..

　

(Note: At present, this drug is only approved for the treatment of diabetes in China, but it has not been approved for weight loss! )

　

Smegliptide also shows great potential in the prevention and treatment of Alzheimer’s disease, nonalcoholic hepatitis, cancer and kidney disease, and it is quite aspirin-like "cure all diseases". In October last year, after Novo Nordisk announced the "positive experimental results" of smegliptide in the treatment of diabetic nephropathy, the share prices of many dialysis manufacturers fell. And this story has happened many times in the medical field.

　

The announcement shows that the efficacy of smegliptide has reached the expectation.

　

Therefore, the experiment was terminated early ▼

　

　

Lilly, a pharmaceutical giant, was originally a small company, but relied on its keen sense of smell to take the lead in obtaining insulin patents and monopolize the global market. However, in the 1980s, Novo Nordisk insulin injection pen went on the market, and this convenient and easy-to-use product sold well when it went on the market, which opened the era of hegemony in the diabetes drug market.

　

All these remind people that technology is constantly reshaping this market.An innovative achievement may create a new giant.; Another case is the wave caused by the listing of oral version of smegliptide in China in early 2024.

　

The oral version is also only approved for diabetes treatment.

　

Not approved for general weight loss!

　

(Photo: National Medical Products Administration) ▼

　

　

Massive capital investment and endless new achievements have created a vibrant biomedical industry today. In the past few decades, China, the fastest growing economy in the world, actually has a long-term shortcoming in the biomedical industry.Can you make up this short board?

　

China medicine, difficult to move forward.

　

Taking medicine when you are sick is something that everyone has to experience. However, the expensive drug price has become a pain in patients’ hearts. The dilemma in Dying to Survive may happen to each of us.

　

The reason why the drug price is so high is related to the current high cost of drug research and development:10 years, 1 billion dollars. For a long time, the pharmaceutical industry has been dominated by a group of large multinational pharmaceutical companies. On the one hand, it has high research and development costs and technical barriers. On the other hand, monopoly status means strong pricing power. Such a market situation has created amazing profit margins for large pharmaceutical companies: in 2023, the annual sales of smeagoutide reached $21.142 billion.

　

Novo Nordisk Meglumine Peptide Related Products Financial Report ▼

　

　

The pharmaceutical industry in New China originated from the eldest son of the Republic medicine-Shijiazhuang Huabei Pharmaceutical FactoryThe first batch of domestic penicillin in China was born here. However, due to our late start and weak foundation, we have never had any industrial advantages except for traditional Chinese medicine products with local characteristics for a long time. When foreign pharmaceutical companies with strong R&D strength and mature business model enter China, they are like wolves in the flock. If they don’t catch up, the pharmaceutical market of more than one billion people will be completely lost.

　

Chinese medicine is a symbol of moderns in Shijiazhuang ▼

　

　

At that time, China’s R&D ability was very weak, so we could only start with the production of basic raw materials for drugs. The ingredients of the raw materials are fixed, and the production process is relatively mature. As long as you are willing to do it, you can produce products. But the middle and lower reaches of this international industrial chain can receive a large number of orders only because of low labor costs. Moreover, the technological level was limited at that time, and the pollution in the production process was very serious.

　

This is obviously not a long-term solution. The vast market of all kinds of new drugs attracts China enterprises. Since they can’t make high profits in developing new drugs, let’s start with generic drugs and get a slice of the huge market first. Nowadays, many backbone enterprises in the pharmaceutical industry in China (such asHengrui Pharma, the heavyweight stock of biomedical ETF), it is in these two waves that the initial accumulation has been completed and it has moved to the upper reaches of the industrial chain.

　

From generic drugs to self-developed drugs

　

Enterprises need a certain amount of time to accumulate and precipitate.

　

(Photo: Picture Worm Creativity) ▼

　

　

At this time, the pharmaceutical industry in China has made great progress. But after all, I still follow in the footsteps of others, and I only earn a fraction of the big international pharmaceutical companies. If you really want to gain a foothold in the biomedical industry, you need to come up with your own things and change the old thinking and industrial model as a whole.Only by thoroughly remoulding oneself can we really grow up.

　

It is not only an economic and commercial issue to enlarge the local pharmaceutical industry. Even in the era of high globalization, the regional differences of health problems in different countries need the developed biomedical industry in their own countries.

　

For example, the Texas Medical Center mentioned at the beginning

　

Has the largest cancer center in the United States

　

(Photo: MD Anderson)▼

　

　

For example, due to the differences of environment and living habits in different countries, the incidence of cancer, the big health killer in the aging era, is different in different countries. The incidence of lung cancer and nasopharyngeal carcinoma in China is obviously higher than that in Europe and America, and esophageal cancer patients account for half of the world. Only by establishing an independent biomedical industry system can we better provide targeted treatment for patients.

　

Make your own medicine

　

Cancer, in most people’s minds, is equated with terminal illness. But the progress of modern medicine is enough to make this an old yellow calendar.

　

One of the major difficulties in cancer treatment is that cancer tissue has a strong ability to deceive, and it will "hide" itself under the guise of the identification mechanism in the human immune system to prevent cannibalism. In other words, if drugs can be used to "remind" the immune system and "catch the mole", it can play a role in preventing and treating cancer.

　

"There is a mole, terminate the transaction."

　

(T cells surround identified cancer cells)

　

(Photo: NICHD/J. Lippincott-Schwartz)▼

　

　

Research in this field has been carried out for decades, among whichPD-1/PD-L1 has attracted much attention from scientists.. Cancer cells will suppress T cells through this in vivo inhibitor, making it think it is a "friendly army". Scientists have developed drugs to block the inhibitory signal pathway between T cells and tumor cells, so as to "restart" the human anti-cancer mechanism.

　

Microscopically, PD-L1 positive lung adenocarcinoma cells

　

(Photo: wiki)▼

　

　

Such drug development requires high technology and in-depth study of human immune system. In the past, it was estimated that multinational pharmaceutical companies developed and sold high prices, and then domestic pharmaceutical companies waited for the patent period to pass a wave of imitation. However, times have changed.

　

By the end of 2023, 17 PD-(L)1 products have been approved for listing in China market, of which more than half are domestic products. In addition to PD-1 target, drugs such as PARP and CDK4/6 have also been successfully developed. Hengrui Pharma is one of the most important manufacturers in this field in China. Its biopharmaceutical products cover lung cancer, nasopharyngeal carcinoma and other high-risk cancer categories in China, and a large number of drugs are in the clinical research stage.

　

Some cancer-related drugs in Hengrui Pharma.

　

(Photo: Hengrui Pharma) ▼

　

　

But at present, the human response rate of PD-(L)1 drug is not high enough, and scientists are still improving it.

　

Since antibodies can recognize tumor tissues, people naturally think: Can you directly use it with chemical drugs to accurately find cancer cells and give him a "total annihilation"? After all, no matter how hard you work, you are afraid of a kitchen knife: no matter how tough a cancer cell meets a high dose of chemical drugs, it will only disappear.

　

Schematic diagram of the action mechanism of antibody-coupled drugs

　

(photo: ADCREVIEW)▼

　

　

This is antibody-based coupled drugs (ADC), which is one of the main anticancer drugs at present.. The principle is simple, but there are many difficulties in research and development: how do protein primers connect with "toxins" that attack cancer cells? How to ensure that you don’t play your medicine too early on the way to the "enemy camp"? How to "exit" in case of entering normal cells of human body? As a result, ADC drugs with complex structures have become research and development black holes. Once the research and development fails, it is difficult to find out which link has a moth.

　

How to design the parts of antibody conjugates

　

It is a big problem to maximize the drug effect ▼

　

　

In the past, this was the natural technical moat of large multinational pharmaceutical companies, which could greatly increase the price of drugs; But now, this is still the stage for China pharmaceutical companies to show their fists:At the end of 2023, BL-B01D1, an ADC dual-antibody drug for lung cancer and breast cancer, was developed by Bailey Tianheng, which set a record for China drugs to go to sea. Successfully went to sea with a down payment of $800 million and a potential price of $8.4 billion..

　

China’s biomedical industry has not only quickly caught up with the world-class phalanx, but also achieved a leading position in some fields.

　

Bai Li Tian Heng represents China Biomedical Haoheng.

　

(Photo: Bai Li Tian Heng) ▼

　

　

Both PD-1 and ADC use drugs to enhance the immune cell ability of human body or kill cancer cells. Then, directly enhancing the recognition ability of human immune cells can also achieve anti-cancer effect? It sounds like science fiction, but it has been realized in reality: using genetic engineering technology to inject receptor genes that can recognize the corresponding tumor cell antigens into immune T cells, so that they can accurately identify cancer cells. This is the CAR-T cell therapy technology.

　

Process diagram of CAR-T cell therapy technology

　

(Photo: MUSC)▼

　

　

At present, CAR-T is mainly used for the treatment of hematological cancers, including well-known leukemia. There are only ten models on the market in the world, and China has four models, including Regiosai injection of Wuxi PharmaTech, which is heavily held by biomedical ETF. In addition to the treatments already on the market,There are hundreds of CAR-T therapies being developed in China, the largest number in the world..

　

China’s bio-pharmaceutical industry, which once could only follow the big international pharmaceutical companies, has finally grown up.

　

Reggiorense injection is the second CAR-T product approved in China.

　

It is also the first CAR-T product of Class 1 biological products in China.

　

(Photo: Wuxi PharmaTech) ▼

　

　

The overall progress of this industry is inseparable from the joint efforts of this huge industrial chain. The listing of any drug requires sufficient clinical trial evidence and approval of relevant departments. For a long time, the approval speed of new drugs and new medical devices in China is slow, and a large number of drugs to be approved often pile up. In the high-speed development of drug research and development track, any time delay will miss business opportunities.

　

Since August 2015, the State Council issued the Opinions of the State Council on Reforming the Examination and Approval System of Medicines and Medical Devices, and a series of reform measures have been introduced one after another. In 2019, the newly revised Drug Administration Law established the MAH system for listed licensors, which mobilized the enthusiasm of more new drug research and development. The response of the market and industry is also extremely rapid, and various breakthroughs of biomedical enterprises in China have emerged in succession.

　

The core of MAH system is to separate drug marketing license from drug production license.

　

Allow pharmaceutical production enterprises, R&D institutions or researchers.

　

Become an independent drug marketing license holder

　

(Photo: Drug Administration Law) ▼

　

　

Go out to sea and look to the future.

　

The breakthrough in the related fields of innovative cancer drugs is only one aspect of the rapid progress of the biomedical industry in China. With the deepening of people’s cognition, medicine is more than just taking medicine to see a doctor; The future medicine will be a whole from genes to society. The biomedical industry in China is also making all-round progress.

　

Biomedicine in China is making efforts.

　

(Photo: Yitu. com) ▼

　

　

Since the 21st century, people have made many breakthroughs in cancer treatment. But no matter how to treat it, it is a process of suffering for patients. It would be best if it could be prevented.

　

At present, the human papillomavirus vaccine (HPV) is the only vaccine that has an obvious preventive and therapeutic effect on cancer (cervical cancer). Originally, it was expensive and all of it relied on imports. Many cities were in short supply and even went to Hong Kong to fight. nowDomestic bivalent HPV vaccine has been put on the market, and the cost of vaccination has been greatly reduced..

　

Bivalent HPV vaccine independently developed and produced by watson biological.

　

A needle costs less than 400 yuan.

　

(Photo: released by Kunming) ▼

　

　

People’s recognition of domestic vaccines is real.Zhifei Bio and watson biological held by Biomedical ETF.They all rely on relevant vaccine products to achieve good results in the capital market. It can be expected that this market will continue to grow after the domestic nine-valent vaccine is listed around 2025.

　

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Under the constant technical update,The pharmaceutical industry will continue to reshuffle and opportunities will continue to emerge..

　

An unprecedented wave of aging has arrived, and the biomedical industry with long-term sustainable development potential is undoubtedly the biggest outlet under this trend. Houston Medical City has proved to us that this industry has unlimited potential and long-term stability, and it is also a great opportunity for the city to realize industrial transformation. For individual investors, this is a win-win choice to support national health and obtain stable investment income; For practitioners, the market is changing with each passing day, and there are many opportunities but fierce competition.

　

To win the hard bones in the field of medicine, we need to unite from policy to market, as well as various therapies and all directions. Various fields with great prospects will gradually merge into one. It should be only a matter of time before China has its own world-class medical center.

　

Swipe up and down to view references:

　

Arnold, C., Webster, P. 11 clinical trials that will shape medicine in 2024. Nat Med (2023).

　

Chau, C.H., P.S. Steeg, and W.D. Figg, Antibody-drug conjugates for cancer. Lancet, 2019. 394(10200): p. 793-804.

　

Hao
MM, Stamp LA. The many means of conversation between the brain and the
gut. Nat Rev Gastroenterol Hepatol. 2022 Dec 14. doi:
10.1038/s41575-022-00725-4. Epub ahead of print. PMID: 36517617.

　

Hu
Y M , Guo M , Li C G ,et al.Immunogenicity noninferiority study of 2
doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine
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Z, Chen Y, Liu D, et al. The landscape of cancer research and cancer
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R G , Mackall C L .Clinical lessons learned from the first leg of the
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25(9):1341-1355.DOI:10.1038/s41591-019-0564-6.

　

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A, Hinder M, Dodel A, Gassmann O, Hartl D. Investigating the origins of
recent pharmaceutical innovation. Nat Rev Drug Discov. 2023
Oct; 22(10):781-782. doi: 10.1038/d41573-023-00102-z. PMID: 37407752.

　

Wiener CM, Wang Qing, Yin Kanhua. "From gene to society" —— Design logic and implementation process of the new curriculum system of Johns Hopkins University School of Medicine [J]. Fudan Education Forum, 2012 (3): 7. DOI: 10.3969/j.ISSN.1672-0059.2012.03.

　

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J , Xie Y , Ren L ,et al.GLP-1 improves the supportive ability of
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2021:101180.DOI:10.1016/j.molmet.2021.101180.

　

Li Wenshuo. Medical Industry and Urban Renewal: the Transformation Road of Pittsburgh, an American Industrial City [J]. Qiushi Journal, 2017,44 (6): 7. doi: CNKI: Sun: qsxk.0.2017-06-022.

　

Li Zhenying. On the transformation strategy and policy of Pittsburgh, the American "Steel Capital" [J]. Journal of Quanzhou Teachers College, 2009 (03): 82-86. DOI: 10.3969/j.ISSN.1009-8224.2009.03.016.

　

Pan Wenzhuo, Cao Yongkang. Historical investigation of urban renewal in the United States-taking Pittsburgh as an example [J]. 2019.

　

Ye Xiaozhen, Shao Jiaqing. Progress in clinical application of smegliptide [J]. Chinese Journal of Diabetes, 2022,14 (Z1): 1-8. DOI: 10.3760/CMA.J.CN115791-20220721-00353.

　

Yin Junxiang,. High-tech Park Leading Regional Economic and Social Development —— Development Experience and Enlightenment of Texas Medical Center in the United States [J]. Outlook of Global Science and Technology Economy, 2015,(07).

　

National Health and Wellness Committee of People’s Republic of China (PRC), Guidelines for Diagnosis and Treatment of Diffuse Large B-cell Lymphoma (2022 Edition).

　

2023
BREAKTHROUGH OF THE YEAR. Retrieved December 14, 2023 from
https://www.science.org/content/article/breakthrough-of-the-year-2023

　

* The reference to individual stocks is for reference only and does not constitute investment advice.

　

* The content of this article is provided by the author and does not represent the position of the Earth Knowledge Bureau.

　

Cover: Yitu. com

　

END

　

　

　　In 2020, under the catalysis of the epidemic, star live broadcast with goods became one of the key words of this year’s industry.

　　Since April, there have been more and more stars with live broadcasts. According to incomplete statistics, more than 100 stars, including Liu Mintao, Amanda, Zheng Shuang, Chris Lee and Z.TAO, appeared in the live broadcast room or e-commerce parties on major platforms in the recently concluded 618 Shopping Festival. And stars including Wang Han, Tamia Liu and Michael Chen have opened their own live broadcast rooms, and started to do live broadcast with goods alone.

　　From the "re-employment of dead stars" to the arrival of many stars, live broadcast with goods has gradually become a new outlet in the industry. However, what is the effect of star with goods?

　　From a little low to a craze,

　　Live broadcast with goods into a star "sideline"

　　Before this year, there seems to be a natural and insurmountable gap between live broadcast and stars. Last June, Ada had a live broadcast with goods on a live broadcast platform. During the activity, she stood with online celebrity, the head of the platform, shouting and selling goods. This live broadcast with goods made Ada board the hot search, which was followed by the ridicule of netizens.

　　At that time, the stars who went to live broadcast with goods were closely connected with the word "out of breath", so most of the stars and star teams were resistant to live broadcast with goods, and fans would feel that it was a bit low for their idols to live broadcast with goods.

　　But what I never expected was that in the past year alone, star live broadcast with goods has become a trend, and some netizens even joked that "at present, the live broadcast platform has propped up half of the entertainment circle".

　　Beginning in April, CCTV News launched a special live broadcast of public welfare goods, and CCTV hosts and artists such as Zheng Shuang and Wong Cho Lam joined in one after another. "CCTV boys" also created a good result of more than 500 million turnover in three hours; In May, Tamia Liu launched a live broadcast with goods in Taobao as the "Chief Optimization Officer of Juhua Cost-effective", and the sales in three hours reached 148 million; In June, the hit variety Sister Braving the Wind and Waves cooperated with Tik Tok, and many "sisters" in the program will appear in the live broadcast room for a total of 12 live broadcasts with goods.

　　In just one year, everyone’s attitude towards live broadcast with goods has changed so much. What do the stars really like about live broadcast with goods before they are willing to put down their posture and enter the live broadcast with goods?

　　To some extent, the "incarnation" of the stars is the result of market demand. In the past two years, the film and television industry has been hit hard, especially the epidemic situation has made the film and television winter worse, the start of the crew has shrunk dramatically, and the job opportunities of the stars have collectively decreased. The offline content is blocked, and all walks of life have turned to "online". The live broadcast of goods above the tuyere can be said to be the hottest publicity exposure at the moment, opening up a new path for the stars who are "waiting for employment". According to the Beijing News, waist artists’ income from a brand live broadcast is generally six figures, which is higher than that from participating in a variety show recording, and they can also get corresponding publicity resources, which can be described as killing two birds with one stone.

　　At the same time, e-commerce and short video platforms have also shown an embrace attitude towards the live broadcast of stars with goods, and launched a series of support policies to vigorously attract star users. For example, Taobao Live launched the "Star Start Plan" and gradually increased the intensity of introducing stars; After Tik Tok invested the resources of the whole station to make the live broadcast with goods in Luo Yonghao the first shot, it attracted more stars to join the ranks.

　　From the occasional guest promotion to the opening of the live broadcast room, the star with its own traffic enters the game, and the platform is naturally happy. Last year, only some stars who had no burden took the lead in testing the water. For example, Li Xiang changed his Weibo name to "anchor Li Xiang" and threw himself into the live broadcast craze. For example, stars such as Wong Cho Lam and Aaron Kwok parachuted into online celebrity’s live broadcast room. This year, it has become a visible trend for stars to sink and live with goods.

　　Live delivery is actually a "technical activity"

　　The reason why the platform attaches importance to the live broadcast of stars with goods is that stars can bring traffic and attention to the platform and accelerate the destruction of the circle. This year, the epidemic has also brought a big impact to the e-commerce platform. According to the data, in the latest quarterly report, compared with the previous quarter, Alibaba’s revenue fell by 7.55%, JD.COM fell by 14.3%, and Pinduoduo plunged by 39.4%.

　　As a result, Taobao Live invited 300 stars to start the tide of star goods; Poly-cost-effective, together with Tamia Liu, Jing Tian, david lee and other stars, entered the live broadcast ecology with 10 billion subsidies; JD.COM Live took the "Beijing Consumer Season" as an opportunity to invite a number of well-known hosts to bring goods in the form of recommenders. For a time, e-commerce platforms have been laid out to seize star resources.

　　The addition of stars has indeed played a role in stimulating traffic and realizing sales transformation to a certain extent. In the following table, the first show record of live broadcast of stars with goods is sorted out, among which Zhang Ting, who has been working hard in the e-commerce industry for many years, won the first place, and stars such as Yuqi Zhang, Hua Shao, Wang Han and Tamia Liu also created the first show sales exceeding one trillion.

　　However, as can be seen from the table, there are only a few stars who can take the lead, and it is not easy for most stars to do live broadcast with goods. Even if these stars bring their own traffic, it may be more fans and people who eat melons than real consumers who gather in the live broadcast room. Therefore, compared with koL, the head of the live broadcast platform, the data of the stars’ goods is obviously dim. Even though the stars tried their best to imitate the various words of the head anchor and threw away their baggage and shouted "Buy in buy buy" in the live broadcast room, many stars were labeled as unsuitable.

　　Lin Yun started his first show with goods in Taobao live broadcast room, "Jelly Lin premiere, allow you good things". According to the data of melon, 888,700 people watched UV in a single live broadcast, with 26,000 pieces of goods sold, and the peak number of online users was only 17,100. Li XiaoLu’s debut with goods also frequently overturned. When introducing products, I almost read them according to the manuscript, and I also misspoke the price of the products. I am not familiar with the goods I brought, so I can only rely on the anchor friends to help me.

　　Therefore, at present, most e-commerce platforms still adopt the relatively safe operation mode of "star+anchor", which combines the specialty of the anchor with the traffic topic of the star. However, for some stars, they are unfamiliar with products and lack of professionalism, which makes them a "tool person" who politely cooperates with the anchor. It is inevitable that they are somewhat embarrassed.

　　Is it a long-term good business to bring goods live by stars?

　　At present, most stars participate in live broadcast with goods, or cooperate with the anchor in the form of "airborne" live broadcast or holding activities, not as a profession as the anchor, and the star live broadcast with goods is still in the exploration stage. Moreover, although the live broadcast of the stars brings high exposure to themselves to a certain extent, at the same time, a series of problems such as live broadcast rollover and follow-up product quality caused by unfamiliar business are also likely to cause a crisis of public trust in the stars.

　　On the one hand, the stars increase their exposure through the current hot e-commerce live broadcast, narrow the distance with fans, and establish an affinity for people, thus further circling the powder. In the previous live broadcast of Li Jiaqi and Yang Mi, Li Jiaqi was accused by netizens for her improper speech, while Yang Mi’s response to high emotional intelligence in the live broadcast made many netizens’ impression of her change; When Jin Jing, a comedian, visited the live studio in Li Jiaqi, she not only explained the products skillfully, but also made funny jokes one after another. Many netizens joked that "even Li Jiaqi will lose his job".

　　On the other hand, the live broadcast of stars with goods is also very likely to cause controversy, which will have an impact on their own performing arts. Frequent exposure consumes its own influence. If the stars frequently bring goods live, the audience will gradually get used to the appearance of them shouting "buy it, buy it" in the live broadcast room. When they return to their own performing arts career, the audience may find it difficult to get into the show for a while. The rollover phenomenon in live broadcast, such as high price, quality problems and after-sales situation, not only affects product sales and loses more and more consumers, but also may affect the audience’s evaluation of their personal image and works.

　　In addition, regardless of the ability to carry goods, the live broadcast itself has certain risks. Once the car rolls over, it will bring negative effects to itself, and even ruin one’s acting career. Zhai Tianlin, who doesn’t know HowNet, and Tong Zhuo, who changed his identity from "previous student" to "new student" by some means, are the best examples.

　　In the market environment where the film and television industry has not yet recovered, there may be more stars moving towards the road of live broadcast with goods. However, with more and more stars entering the market, consumers will tend to be rational sooner or later, and the bonus brought by the star aura will gradually decrease. At that time, the threshold of "live broadcast with goods" will be raised accordingly. Without the title of "star", I am afraid it is difficult to win the "killing" in the live broadcast of rivers and lakes.

　　— THE END —

　　Author | Li Yang

　　Editor | Yang Ni

　　Recently, Minhou County, Fuzhou City, Fujian Province, has effectively eased the cash flow pressure of automobile enterprises and added impetus to the development of automobile industry by implementing tax reduction and fee reduction policies such as value-added tax deduction and tax refund. The picture shows workers of an automobile enterprise in Minhou County assembling vehicles in the assembly workshop. Photo by Wang Wangwang (People’s Vision)

　　Activate the used car market, support the consumption of new energy vehicles and improve the parallel import policy of automobiles & HELIP; … A few days ago, the the State Council executive meeting focused on promoting automobile consumption, and deployed a series of policy measures from various aspects. The policy implementation predicted that the automobile and related consumption would increase by about 200 billion yuan this year.

　　Accelerated circulation of used cars

　　The meeting proposed to enliven the used car market and promote the renewal of automobile consumption. For small non-operating used cars, the restrictions on moving in cars that meet the national five emission standards will be completely lifted from August 1. From October 1, automobile sales enterprises will implement separate endorsement management and issue temporary license plates when applying for transfer registration.

　　In recent years, China has issued a series of policies to support the circulation of used cars, including abolishing the restrictions on the movement of used cars, reducing the value-added tax of used car distribution enterprises, and making the registration of used car transactions universal across provinces. Although the circulation environment of used cars in China has obviously improved, compared with mature automobile market countries such as Europe, America and Japan, its development is still immature. Cui Dongshu, secretary-general of the Passenger Car Market Information Association, told this reporter: "China’s used car industry has not got rid of ‘ Small, scattered and weak ’ The situation, the restrictions on the movement of used cars, the constraints of taxation methods and the lack of temporary property rights registration were important reasons that hindered the convenient circulation of used cars. "

　　In May this year, the State Council issued "A Package of Policies and Measures to Stabilize the Economy", proposing to completely cancel the policy of restricting the movement of second-hand cars, lift the restrictions on the movement of small non-operating second-hand cars that meet the national five emission standards nationwide, and improve the regulations on the registration, filing and vehicle transaction registration of the main body of the second-hand car market.

　　The Standing Committee of the National People’s Congress clearly proposed to accelerate the activation of the used car market, and gave a clear implementation date for the comprehensive cancellation of the restrictions on the movement of used cars and other related measures. "The complete cancellation of the restrictions on the movement of used cars will greatly promote the flow of used cars, further enrich the sources of used car markets and promote the formation of a unified national market for used car transactions. Especially for car dealers, this is undoubtedly a ‘ Gift package ’ 。” Cui Dongshu said.

　　According to the China Automotive Strategy and Policy Research Center of China Automotive Technology and Research Center, it is predicted that about 4.9 million old cars in China need to be updated this year. According to the average selling price of new cars of 150,000 yuan, the updating of these old cars is expected to bring 735 billion yuan of consumption-driven effect this year.

　　Support the consumption of new energy vehicles

　　The meeting made it clear that it is necessary to support the consumption of new energy vehicles. Vehicle purchase tax should be mainly used for highway construction, etc., considering the current practical research on the extension of the policy of exempting new energy vehicle purchase tax after the end of the year. Break the local protection of the new energy vehicle market.

　　"The cumulative sales volume of new energy vehicles has risen sharply from 20,000 at the end of 2012 to 11.08 million at the end of May this year. Since 2015, production and sales have ranked first in the world for seven consecutive years." Xin Guobin, Vice Minister of the Ministry of Industry and Information Technology, said recently that China’s new energy automobile industry has become an important force leading the transformation and upgrading of the global automobile industry.

　　China has been exempted from vehicle purchase tax for new energy vehicles since September 1st, 2014. After the implementation of the policy, the purchase cost of new energy vehicles has been effectively reduced and the consumption of new energy vehicles has been directly promoted. According to the current policy, the tax exemption policy will expire on December 31, 2022.

　　China Automotive Strategy and Policy Research Center of China Automotive Technology and Research Center pointed out that this regular meeting of the National People’s Congress clearly proposed to consider the extension of the current practical study on the exemption of new energy vehicle purchase tax policy, which will promote the relevant departments to speed up the research, comprehensively consider key factors such as tax revenue and industrial development, and put forward practical policy plans to better play the guiding role of policies in the industry.

　　Cui Dongshu suggested that the policy of exempting new energy vehicles from vehicle purchase tax should continue until 2023, and study the implementation method of gradually resuming the collection of vehicle purchase tax, so as to turn the collection of vehicle purchase tax into a tool to stimulate the consumption of new energy vehicles, ensure a smooth transition and continuously improve the penetration rate of new energy vehicles.

　　Consumers will have more choices.

　　The meeting stressed that it is necessary to improve the parallel import policy of automobiles, develop automobile financing leasing in an orderly manner, and support the construction of parking lots.

　　Cui Dongshu introduced that for consumers, parallel imported cars simplify the circulation and allow consumers to buy imported cars at more affordable prices; The policy of parallel import of automobiles has realized the simultaneous listing of foreign products in China market, enriched the models of automobiles and won the favor of consumers.

　　Since the pilot of parallel import of automobiles was deployed in the State Council in 2014, the scope of the pilot of parallel import of automobiles has been gradually expanded, the import volume has been increasing, and the imported models have become increasingly rich, which has played an important role in breaking the monopoly of imported automobiles, accelerating the innovation and development of automobile circulation system, stimulating the vitality of automobile market, and meeting the diversified needs of consumers. Up to now, 22 of the 29 vehicle import ports in China are carrying out parallel automobile import business.

　　Cui Dongshu said: "The clear improvement of the parallel import policy this time will help to solve the key problems in the development of parallel import of automobiles as soon as possible, and also help to comprehensively expand the pilot effect. It is even better news for consumers, which will help restore consumer confidence and stimulate consumer demand. "

The writer of this article is the writer @ 中中中中中中中中.

I am greedy and lazy, I don’t like labor, I just love movies.

In the last two weeks, many people around me have been watching an Amway domestic drama, The Beginning.

300+ Weibo hot searches, 200,000 people’s passionate scores, and 8.2 douban scores are all in full swing to discuss the plot trend.

It was the first drama of the year.

The Beginning is adapted from the novel of the same name by Prayer Jun and tells a story about the cycle of time.

After a bus exploded, Li Shiqing (Angel) found herself in a time cycle, going back to the minutes before the explosion.

After she pulled her neighbor Xiao Heyun (Bai Jingting) into the cycle, the two of them started time adventures again and again.

They want to save their own lives and the lives of the whole car, and they want to find out who set off the bomb in the car.

There are 15 episodes in the series, so far 13 episodes have been broadcast, and the protagonists have gone through 24 cycles.

The murderer is already in the light, and the rest is to see how the protagonist can minimize the damage and solve the bomb crisis. I believe how many people can’t wait to see the finale.

The opening year of "The Beginnings" is very surprising. It presents a concept of "infinite flow" which is not new now to the audience with new actors and new topics.

On the home page of the original novel "Beginnings", three keyword tags were posted, namely: infinite flow, Puzzle-solving Style and Confined Space.

Infinite flow, which is very close to the concept of time cycle, is a type of classification, which is common in bamboo slips and foreign dramas.

Baidu Encyclopedia’s definition of infinite flow is more general-

"All-encompassing, including infinite elements, including science, religion, mythology, history, reality, movies, animation, etc., and above them, there is a reasonable world outlook that includes all these."

But to be more precise, infinite flow refers to the samsara who keeps breaking through in the replica world, and completing the task is the way to settle down.

In this way, The Beginning can only be regarded as a branch of infinite flow: Time Loop.

Li Shiqing and Xiao Heyun don’t have much autonomy, but they are constantly pushed back to the time node when the bomb got on the bus by force majeure, and they read the files again and again.

There are not many choices in front of them, only getting off or not getting off: getting off means stealing half a day’s leisure and recycling tomorrow; Not getting off the bus means two choices: stop the explosion and still explode.

They tried one by one in several cycles, and it was difficult to find a satisfactory solution.

Although there are not many works of Time Loop series in China, if we look around the world, we will find that it has long been a mature drama mode.

Groundhog Day, a comedy, tells the story of a bored weatherman trapped in a groundhog celebration day, reminding us to live in the present with his great insight.

The horror category includes "Happy Death Day". The beautiful woman died on her birthday. She is constantly resurrecting to find the real murderer who killed herself in an attempt to jump out of the time cycle.

The suspense category includes Source Code. The pilot wakes up repeatedly on the train to look for hidden bombs, only for 8 minutes at a time, and all this is his brain performing the task of brainwave source code.

At the beginning of the broadcast of "Beginning", it also caused a small-scale questioning storm because of its frequent collision with "Source Code".

We can understand why different audiences have different views on The Beginning, which depends on everyone’s aesthetic psychological threshold.

If you have seen many Time Loop works on weekdays, you will feel that "Beginning" is playing in old terrier; If you are a younger generation audience who have little contact with this type before, you will taste many innovations in the beginning.

After all, in the popular domestic drama category, The Beginning is quite innovative and sincere.

Let’s look at the other two labels of the beginning: puzzle wind+confined space. When these two elements collide with each other, we can easily think of the reasoning works of the storm villa model.

However, chasing the murderer by reasoning is not the focus of the beginning at all.

Li Shiqing and Xiao Heyun, the protagonists, have not been portrayed as omnipotent salvation heroes, and their reasoning ability is not very good. Finding the murderer depends on trial and error again and again.

In the end, they finally found out who the murderer was. At this moment, more than half of the passengers in the car have been tried by them.

Xiaowan believes that the fire of Beginnings lies not in its imitation of mature models, nor in the deliberately inserted suspense detection line, but in the presentation of local social reality problems.

In other words, it doesn’t follow the science fiction school or the reasoning school, but the social sentiment school.

In 5~8 episodes, Li Shiqing and Xiao Heyun began to investigate the suspects on the bus. The drama opens God’s perspective and fills the background of passengers. Almost everyone has a story.

Liu Dan’s "malicious role" successfully came out of the circle.

Lu Di, an anime fan who is immersed in the second world, is the only person in the whole car who unconditionally believes in recycling theory. He is gearing up to circulate with the protagonist, thus becoming the savior in the animation he has seen.

He also promised that in case he didn’t enter the cycle, the protagonist could call him by calling out his nickname. At the critical moment of episode 10, Xiao Heyun successfully used his nickname to harvest an effective labor force.

This line symbolizes sincere idealism. Lu Di is not only like a middle school patient who didn’t grow up, but also has all the characteristics of a passionate protagonist. He reflects the innocence that the adult world can’t tolerate.

Passengers Ma Guoqiang and Lao Jiao both appeared as suspicious villains. Ma Guoqiang hit and run many years ago, carrying his life on his back and serving several years in prison.

But on the other hand, his elderly father went to the city to look for his son, and brought a whole bag of the sweetest watermelon in his hometown to his son who didn’t want to meet him.

Laojiao is the most common migrant worker in the city, living in someone else’s garage, just to send home the reward for doing odd jobs for her daughter to study. Lao Jiao’s suitcase is even stuffed with bulk sanitary napkins for her daughter.

The killers are not terrorists who have been flattened, and the secrets behind them are scary and bleak. Many times, the perpetrator’s last identity is the victim.

"Beginning" continues to outline the story behind the supporting roles until their images become more and more warm, so that every audience can easily associate with an acquaintance or passer-by in their lives.

The Noon Sunshine Company, which produced "The Beginning", happens to be very good at writing stories of sadness and joy at the bottom. For example, last year’s "Children of the Qiao Family" described the family story struggling on the edge of the city with great efforts.

In The Beginning, Noon Sunshine Company did the same thing, touching people’s hearts with the gripping stories of bus passengers, mobilizing the audience’s senses and memories, thus achieving emotional resonance.

While profiling the joys and sorrows of small people, it also faintly reflects the shadow of social news: the murderer who was violently attacked by the internet actually has another origin; Grab the driver’s steering wheel and be resisted by the whole car; Three-no sanitary napkins in bulk are the difficulties of many poor women …

Creators gradually build up the blood and flesh of society in accordance with the tendons and bones of realism.

Time Loop is just a loose condom, which can’t stand scrutiny. It can’t explain the mystery of parallel universe and standby time, but the beginning is not here, and the drama tries to expose some heavier facts and life.

"Beginning" held high the high concept setting, and gently placed it in various social situations. This is out of self-consideration, and it can also be regarded as a cautious attempt in the safe area.

However, The Beginning not only made a good start for the domestic drama market in the New Year, but also set a good example for the film and television of infinite flow’s novels.

Over time, maybe we can see better and bolder domestic dramas of the same type.

Note: Some pictures in this article are from Douban and the Internet. If there is any infringement, please contact us actively.

On March 13th, 2024, the opening ceremony of 2024 Hui ‘ai Carnival and the first Hui ‘ai Exhibition of "Empowering the Future with Science and Technology" hosted by Beijing Disabled Persons’ Federation and hosted by Beijing Disabled Persons’ Service Demonstration Center opened in Hui ‘ai Building, Beijing Disabled Persons’ Service Demonstration Center. The exhibition shows the products and services of science and technology for disabled people with different disabilities, so that the majority of disabled friends can truly feel the convenience brought by the achievements of science and technology for their lives and work through the visit experience of this science and technology exhibition.